| UniProt ID | TM231_HUMAN | |
|---|---|---|
| UniProt AC | Q9H6L2 | |
| Protein Name | Transmembrane protein 231 | |
| Gene Name | TMEM231 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 316 | |
| Subcellular Localization |
Cell projection, cilium membrane Multi-pass membrane protein. Localizes to the transition zone of primary cilia SEPT2 is required for localization to the transition zone.. |
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| Protein Description | Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).. | |
| Protein Sequence | MALYELFSHPVERSYRAGLCSKAALFLLLAAALTYIPPLLVAFRSHGFWLKRSSYEEQPTVRFQHQVLLVALLGPESDGFLAWSTFPAFNRLQGDRLRVPLVSTREEDRNQDGKTDMLHFKLELPLQSTEHVLGVQLILTFSYRLHRMATLVMQSMAFLQSSFPVPGSQLYVNGDLRLQQKQPLSCGGLDARYNISVINGTSPFAYDYDLTHIVAAYQERNVTTVLNDPNPIWLVGRAADAPFVINAIIRYPVEVISYQPGFWEMVKFAWVQYVSILLIFLWVFERIKIFVFQNQVVTTIPVTVTPRGDLCKEHLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MALYELFSHPV ----CCHHHHHCCCC | 10.88 | 30206219 | |
| 8 | Phosphorylation | MALYELFSHPVERSY CCHHHHHCCCCHHHH | 39.23 | 30206219 | |
| 16 (in isoform 2) | Phosphorylation | - | 24.35 | 24719451 | |
| 45 (in isoform 2) | Phosphorylation | - | 22.85 | 24945436 | |
| 181 | Ubiquitination | GDLRLQQKQPLSCGG CCEEECCCCCCCCCC | 40.71 | - | |
| 194 | N-linked_Glycosylation | GGLDARYNISVINGT CCCCCEEEEEEECCC | 17.95 | UniProtKB CARBOHYD | |
| 199 | N-linked_Glycosylation | RYNISVINGTSPFAY EEEEEEECCCCCCCC | 45.60 | UniProtKB CARBOHYD | |
| 210 (in isoform 2) | Ubiquitination | - | 2.82 | - | |
| 221 | N-linked_Glycosylation | VAAYQERNVTTVLND HHHHHHCCCEEECCC | 34.43 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TM231_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TM231_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TM231_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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