dbPTM

POSTN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	POSTN_HUMAN
UniProt AC	Q15063
Protein Name	Periostin
Gene Name	POSTN
Organism	Homo sapiens (Human).
Sequence Length	836
Subcellular Localization	Golgi apparatus . Secreted . Secreted, extracellular space, extracellular matrix . Colocalizes with BMP1 in the Golgi.
Protein Description	Induces cell attachment and spreading and plays a role in cell adhesion. [PubMed: 12235007 Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity]
Protein Sequence	MIPFLPMFSLLLLLIVNPINANNHYDKILAHSRIRGRDQGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRMEGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDDLSSFRAAAITSDILEALGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAVFETLEGNTIEIGCDGDSITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLNELYNGQILETIGGKQLRVFVYRTAVCIENSCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPTNDAFKGMTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVVDKLLYPADTPVGNDQLLEILNKLIKYIQIKFVRGSTFKEIPVTVYTTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGEPIIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLKKLLQEEVTKVTKFIEGGDGHLFEDEEIKRLLQGDTPVRKLQANKKVQGSRRRLREGRSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	PINANNHYDKILAHS CCCCCCCHHHHHHHC	22.51	25348772
56	Phosphorylation	ILGTKKKYFSTCKNW HHCCCHHHHHHCCHH	16.19	29083192
58	Phosphorylation	GTKKKYFSTCKNWYK CCCHHHHHHCCHHHH	29.79	29083192
59	Phosphorylation	TKKKYFSTCKNWYKK CCHHHHHHCCHHHHH	20.01	29083192
83	Phosphorylation	LYECCPGYMRMEGMK EEEECCCCHHCCCCC	2.69	-
189	Phosphorylation	GMIIPSMYNNLGLFI CCCCCHHCCCCCCEE	12.77	22817900
256	O-linked_Glycosylation	SFRAAAITSDILEAL HHHHHHHHHHHHHHH	18.67	OGP
353	Phosphorylation	VNKKDIVTNNGVIHL ECHHHHCCCCCCEEE	24.25	22210691
369	Phosphorylation	DQVLIPDSAKQVIEL EEEECCCCHHHHHHH	31.82	22210691
498	Phosphorylation	IIKPAEKSLHEKLKQ HHHHHHHHHHHHHHH	26.85	-
510	Phosphorylation	LKQDKRFSTFLSLLE HHHHHHHHHHHHHHH	23.45	27251275
511	Phosphorylation	KQDKRFSTFLSLLEA HHHHHHHHHHHHHHH	26.36	27251275
545	Phosphorylation	NDAFKGMTSEEKEIL CCHHCCCCHHHHEEE	41.47	-
546	Phosphorylation	DAFKGMTSEEKEILI CHHCCCCHHHHEEEE	34.56	-
556	Acetylation	KEILIRDKNALQNII HEEEECCCHHHHHHH	33.98	7826023
582	Phosphorylation	KGFEPGVTNILKTTQ CCCCCCCCEEEHHCC	23.58	27251275
599	N-linked_Glycosylation	KIFLKEVNDTLLVNE EEEEEECCCEEEHHC	37.33	16335952
616	Phosphorylation	SKESDIMTTNGVIHV CCCCCCEECCCCEEE	19.90	-
660	Phosphorylation	IKFVRGSTFKEIPVT EEECCCCCCCCCCEE	41.36	-
670	Phosphorylation	EIPVTVYTTKIITKV CCCEEEEECCEEEHH	19.78	-
675	Phosphorylation	VYTTKIITKVVEPKI EEECCEEEHHHCCCE	22.66	-
766	Phosphorylation	EIKYTRISTGGGETE CEEEEEECCCCCCHH	20.08	22985185
767	Phosphorylation	IKYTRISTGGGETEE EEEEEECCCCCCHHH	37.16	22985185
772	Phosphorylation	ISTGGGETEETLKKL ECCCCCCHHHHHHHH	42.25	28857561
775	Phosphorylation	GGGETEETLKKLLQE CCCCHHHHHHHHHHH	37.33	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of POSTN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of POSTN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of POSTN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MKS1_HUMAN	MKS1	physical	27173435
B9D1_HUMAN	B9D1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of POSTN_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599, AND MASSSPECTROMETRY.	19159218 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-599, AND MASSSPECTROMETRY.	16335952 [Abstract]
"Osteoblast-specific factor 2: cloning of a putative bone adhesionprotein with homology with the insect protein fasciclin I."; Takeshita S., Kikuno R., Tezuka K., Amann E.; Biochem. J. 294:271-278(1993). Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).	8363580 [Abstract]