KIF5C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF5C_HUMAN
• UniProt AC: O60282
• Protein Name: Kinesin heavy chain isoform 5C
• Gene Name: KIF5C
• Organism: Homo sapiens (Human).
• Sequence Length: 957
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, dendrite . Abundant in distal regions of dendrites.
• Protein Description: Involved in synaptic transmission. [PubMed: 24812067 Mediates dendritic trafficking of mRNAs (By similarity Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.]
• Protein Sequence: MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21 (in isoform 2)	Ubiquitination	-	14.20	21906983
47	Phosphorylation	VIGQGKPYVFDRVLP EECCCCCEEECCCCC	19.75	27811184
165	Phosphorylation	EDKNRVPYVKGCTER CCCCCCCCCCCCCHH	16.37	30631047
167	Acetylation	KNRVPYVKGCTERFV CCCCCCCCCCCHHCC	42.28	19608861
167	Malonylation	KNRVPYVKGCTERFV CCCCCCCCCCCHHCC	42.28	26320211
196	Phosphorylation	ANRHVAVTNMNEHSS CCCEEEEECCCCCCC	21.00	21406692
202	Phosphorylation	VTNMNEHSSRSHSIF EECCCCCCCCCCEEE	22.67	21406692
203	Phosphorylation	TNMNEHSSRSHSIFL ECCCCCCCCCCEEEE	39.44	21406692
205	Phosphorylation	MNEHSSRSHSIFLIN CCCCCCCCCEEEEEE	24.43	-
225	Phosphorylation	VETEKKLSGKLYLVD CCCHHHHCCEEEEEE	42.64	29391485
227	Ubiquitination	TEKKLSGKLYLVDLA CHHHHCCEEEEEECC	30.49	-
229	Phosphorylation	KKLSGKLYLVDLAGS HHHCCEEEEEECCCC	14.25	28152594
238	Malonylation	VDLAGSEKVSKTGAE EECCCCCCCCCCCCC	54.21	26320211
238	Acetylation	VDLAGSEKVSKTGAE EECCCCCCCCCCCCC	54.21	25953088
241	Ubiquitination	AGSEKVSKTGAEGAV CCCCCCCCCCCCCCH	54.70	-
253	Malonylation	GAVLDEAKNINKSLS CCHHHHHHHHHHHHH	57.20	26320211
253 (in isoform 1)	Ubiquitination	-	57.20	21906983
253	Ubiquitination	GAVLDEAKNINKSLS CCHHHHHHHHHHHHH	57.20	-
274	Ubiquitination	SALAEGTKTHVPYRD HHHHHCCCCCCCCCC	47.71	-
316	Phosphorylation	FNEAETKSTLMFGQR CCCCHHHCCCHHCCC	33.91	-
317	Phosphorylation	NEAETKSTLMFGQRA CCCHHHCCCHHCCCC	24.65	-
326	Phosphorylation	MFGQRAKTIKNTVSV HHCCCCCCCCCEEEE	35.88	-
348	Acetylation	EWKKKYEKEKEKNKT HHHHHHHHHHHHCHH	71.62	6568141
396	Phosphorylation	NLEPCDNTPIIDNIA CCCCCCCCCCCCCCH	11.56	27732954
501	Ubiquitination	LAVNYDQKSQEVEDK HHCCCCCCCHHHHHH	51.73	-
590	Phosphorylation	EFTMARLYISKMKSE HHHHHHHHHHHHHHH	9.52	23836654
593	Acetylation	MARLYISKMKSEVKS HHHHHHHHHHHHHHH	40.57	25953088
596	Phosphorylation	LYISKMKSEVKSLVN HHHHHHHHHHHHHHH	44.09	23836654
610	Phosphorylation	NRSKQLESAQMDSNR HHHHHHHHHHHHHHH	32.18	21406692
615	Phosphorylation	LESAQMDSNRKMNAS HHHHHHHHHHCCCHH	32.94	21406692
639	Acetylation	LISQHEAKIKSLTDY HHHHHHHHHHHHHHH	47.91	25953088
660	Phosphorylation	KRRQLEESQDSLSEE HHHHHHHHHHHHHHH	29.88	-
681	Phosphorylation	QEKMHEVSFQDKEKE HHHHHHCCCCHHHHH	17.76	27422710
692	Methylation	KEKEHLTRLQDAEEM HHHHHHHHHHCHHHH	36.39	115390063
692	Dimethylation	KEKEHLTRLQDAEEM HHHHHHHHHHCHHHH	36.39	-
711	Dimethylation	EQQMESHREAHQKQL HHHHHHHHHHHHHHH	52.67	-
711	Methylation	EQQMESHREAHQKQL HHHHHHHHHHHHHHH	52.67	115390069
753	Phosphorylation	QEKLSSDYNKLKIED HHHHHHHHHCCCHHH	19.02	-
797	Phosphorylation	TVSRELQTLHNLRKL HHHHHHHHHHHHHHH	42.48	21082442
814	Acetylation	QDLTTRVKKSVELDN HHHHHHHHHHEECCC	35.72	7851115
816	Phosphorylation	LTTRVKKSVELDNDD HHHHHHHHEECCCCC	18.33	-
835	Phosphorylation	AAQKQKISFLENNLE HHHHHHHHHHHHCHH	30.71	25159151
846	Ubiquitination	NNLEQLTKVHKQLVR HCHHHHHHHHHHHHH	51.43	-
849	Ubiquitination	EQLTKVHKQLVRDNA HHHHHHHHHHHHCCC	48.60	-
864	Acetylation	DLRCELPKLEKRLRA CCCCCHHHHHHHHHH	80.19	25953088
903	Methylation	RYQQEVDRIKEAVRA HHHHHHHHHHHHHHH	47.24	-
919	Phosphorylation	NMARRAHSAQIAKPI HHHHHHHHHCCCCCC	22.38	22496350
931	Phosphorylation	KPIRPGHYPASSPTA CCCCCCCCCCCCCCE	13.35	21406692
934	Phosphorylation	RPGHYPASSPTAVHA CCCCCCCCCCCEEEE	32.14	29255136
935	Phosphorylation	PGHYPASSPTAVHAI CCCCCCCCCCEEEEC	28.51	29255136
937	Phosphorylation	HYPASSPTAVHAIRG CCCCCCCCEEEECCC	43.17	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
338	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF5C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF5C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KINH_HUMAN	KIF5B	physical	9624122
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615282: Cortical dysplasia, complex, with other brain malformations 2 (CDCBM2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.