| UniProt ID | CBARP_HUMAN | |
|---|---|---|
| UniProt AC | Q8N350 | |
| Protein Name | Voltage-dependent calcium channel beta subunit-associated regulatory protein {ECO:0000305} | |
| Gene Name | CBARP {ECO:0000312|HGNC:HGNC:28617} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 705 | |
| Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Single-pass type III membrane protein . Cell membrane Single-pass type III membrane protein . Cell projection, growth cone . |
|
| Protein Description | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.. | |
| Protein Sequence | MQPTATMATAATTTTTTTATVALTTSWDNATGRPTAEPDPILDNYVLLVVVMSLFVGGTLVVLSGVLLLCKRCWDVHQRLNRAMEEAEKTTTTYLDNGTHPAQDPDFRGEDPECQDAETERFLSTSSTGRRVSFNEAALFEQSRKTQDKGRRYTLTEGDFHHLKNARLTHLHLPPLKIVTIHECDSGEASSATTPHPATSPKATLAIFQPPGKALTGRSVGPSSALPGDPYNSAAGATDFAEISPSASSDSGEGTSLDAGTRSTKAGGPGAAAGPGEAGPGSGAGTVLQFLTRLRRHASLDGASPYFKVKKWKLEPSQRAASLDTRGSPKRHHFQRQRAASESTEQEEGDAPQEDFIQYIARAGDAVAFPHPRPFLASPPPALGRLEAAEAAGGASPDSPPERGAGSAGPEQQQPPLEPDAERDAGPEQAQTSYRDLWSLRASLELHAAASDHSSSGNDRDSVRSGDSSGSGSGGAAPAFPPPSPPAPRPKDGEARRLLQMDSGYASIEGRGAGDDTEPPAAPARPRSPRAWPRRPRRDYSIDEKTDALFHEFLRHDPHFDDTPAAARHRARAHPHARKQWQRGRQHSDPGARAAPALAGTPAPPAGAARPARAPLRRGDSVDGPPDGRTLGGAGDDPAIPVIEEEPGGGGCPGSGLCVLPSGSVLDKLAAGLDERLFPPRLAEPVVATPALVAAAPTSPDHSPA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | N-linked_Glycosylation | ALTTSWDNATGRPTA EEECCCCCCCCCCCC | - | ||
| 118 | Phosphorylation | DPECQDAETERFLST CCCCCCHHHHHHHCC | 26074081 | ||
| 119 | Phosphorylation | PECQDAETERFLSTS CCCCCHHHHHHHCCC | - | ||
| 120 | Phosphorylation | ECQDAETERFLSTSS CCCCHHHHHHHCCCC | - | ||
| 122 | Phosphorylation | QDAETERFLSTSSTG CCHHHHHHHCCCCCC | 26074081 | ||
| 124 | Phosphorylation | AETERFLSTSSTGRR HHHHHHHCCCCCCCC | 26074081 | ||
| 125 | Phosphorylation | ETERFLSTSSTGRRV HHHHHHCCCCCCCCE | 26074081 | ||
| 126 | Phosphorylation | TERFLSTSSTGRRVS HHHHHCCCCCCCCEE | 26074081 | ||
| 127 | Phosphorylation | ERFLSTSSTGRRVSF HHHHCCCCCCCCEEH | 25850435 | ||
| 128 | Phosphorylation | RFLSTSSTGRRVSFN HHHCCCCCCCCEEHH | 26074081 | ||
| 133 | Phosphorylation | SSTGRRVSFNEAALF CCCCCCEEHHHHHHH | 29255136 | ||
| 143 | Phosphorylation | EAALFEQSRKTQDKG HHHHHHHHHHHCCCC | 22210691 | ||
| 152 | Phosphorylation | KTQDKGRRYTLTEGD HHCCCCCCEECCCCC | 21406692 | ||
| 153 | Phosphorylation | TQDKGRRYTLTEGDF HCCCCCCEECCCCCH | 29255136 | ||
| 154 | Phosphorylation | QDKGRRYTLTEGDFH CCCCCCEECCCCCHH | 27273156 | ||
| 156 | Phosphorylation | KGRRYTLTEGDFHHL CCCCEECCCCCHHHH | 29255136 | ||
| 173 | Phosphorylation | ARLTHLHLPPLKIVT CCCCCCCCCCEEEEE | 22817900 | ||
| 174 | Phosphorylation | RLTHLHLPPLKIVTI CCCCCCCCCEEEEEE | 22817900 | ||
| 176 | Phosphorylation | THLHLPPLKIVTIHE CCCCCCCEEEEEEEE | 22817900 | ||
| 190 | Phosphorylation | ECDSGEASSATTPHP ECCCCCCCCCCCCCC | 25002506 | ||
| 191 | Phosphorylation | CDSGEASSATTPHPA CCCCCCCCCCCCCCC | 23312004 | ||
| 193 | Phosphorylation | SGEASSATTPHPATS CCCCCCCCCCCCCCC | 25002506 | ||
| 194 | Phosphorylation | GEASSATTPHPATSP CCCCCCCCCCCCCCC | 27732954 | ||
| 199 | Phosphorylation | ATTPHPATSPKATLA CCCCCCCCCCCEEEE | 25850435 | ||
| 200 | Phosphorylation | TTPHPATSPKATLAI CCCCCCCCCCEEEEE | 25850435 | ||
| 204 | Phosphorylation | PATSPKATLAIFQPP CCCCCCEEEEEECCC | 27251789 | ||
| 219 | Phosphorylation | GKALTGRSVGPSSAL CCCCCCCCCCCHHCC | 25627689 | ||
| 220 | Phosphorylation | KALTGRSVGPSSALP CCCCCCCCCCHHCCC | 22817900 | ||
| 224 | Phosphorylation | GRSVGPSSALPGDPY CCCCCCHHCCCCCCC | 22210691 | ||
| 231 | Phosphorylation | SALPGDPYNSAAGAT HCCCCCCCCCCCCCC | 22210691 | ||
| 246 | Phosphorylation | DFAEISPSASSDSGE CCHHCCCCCCCCCCC | 30576142 | ||
| 251 | Phosphorylation | SPSASSDSGEGTSLD CCCCCCCCCCCCCCC | 22210691 | ||
| 282 | Phosphorylation | PGEAGPGSGAGTVLQ CCCCCCCCCHHHHHH | 27050516 | ||
| 286 | Phosphorylation | GPGSGAGTVLQFLTR CCCCCHHHHHHHHHH | 21712546 | ||
| 299 | Phosphorylation | TRLRRHASLDGASPY HHHHHHHCCCCCCCC | 23401153 | ||
| 302 | Phosphorylation | RRHASLDGASPYFKV HHHHCCCCCCCCEEE | - | ||
| 304 | Phosphorylation | HASLDGASPYFKVKK HHCCCCCCCCEEEEE | 25159151 | ||
| 306 | Phosphorylation | SLDGASPYFKVKKWK CCCCCCCCEEEEEEE | 23403867 | ||
| 317 | Phosphorylation | KKWKLEPSQRAASLD EEEECCHHHHHCCCC | 29514088 | ||
| 319 | Phosphorylation | WKLEPSQRAASLDTR EECCHHHHHCCCCCC | 25850435 | ||
| 322 | Phosphorylation | EPSQRAASLDTRGSP CHHHHHCCCCCCCCC | 25159151 | ||
| 324 | Phosphorylation | SQRAASLDTRGSPKR HHHHCCCCCCCCCCH | 25850435 | ||
| 325 | Phosphorylation | QRAASLDTRGSPKRH HHHCCCCCCCCCCHH | 25159151 | ||
| 328 | Phosphorylation | ASLDTRGSPKRHHFQ CCCCCCCCCCHHHHH | 25159151 | ||
| 341 | Phosphorylation | FQRQRAASESTEQEE HHHHHHHCCCCCCCC | 22617229 | ||
| 342 | Phosphorylation | QRQRAASESTEQEEG HHHHHHCCCCCCCCC | 20363803 | ||
| 343 | Phosphorylation | RQRAASESTEQEEGD HHHHHCCCCCCCCCC | 28387310 | ||
| 344 | Phosphorylation | QRAASESTEQEEGDA HHHHCCCCCCCCCCC | 19276368 | ||
| 345 | Phosphorylation | RAASESTEQEEGDAP HHHCCCCCCCCCCCC | 20363803 | ||
| 348 | Phosphorylation | SESTEQEEGDAPQED CCCCCCCCCCCCHHH | 20363803 | ||
| 359 | Phosphorylation | PQEDFIQYIARAGDA CHHHHHHHHHHCCCE | 23312004 | ||
| 361 | Phosphorylation | EDFIQYIARAGDAVA HHHHHHHHHCCCEEE | 23917254 | ||
| 364 | Phosphorylation | IQYIARAGDAVAFPH HHHHHHCCCEEECCC | 23403867 | ||
| 378 | Phosphorylation | HPRPFLASPPPALGR CCCCCCCCCCCHHHH | 32142685 | ||
| 386 (in isoform 4) | Phosphorylation | - | 29523821 | ||
| 388 (in isoform 4) | Phosphorylation | - | 29523821 | ||
| 396 | Phosphorylation | AEAAGGASPDSPPER HHHHCCCCCCCCCCC | 30266825 | ||
| 399 | Phosphorylation | AGGASPDSPPERGAG HCCCCCCCCCCCCCC | 30266825 | ||
| 404 | Phosphorylation | PDSPPERGAGSAGPE CCCCCCCCCCCCCCC | 23898821 | ||
| 404 (in isoform 4) | Phosphorylation | - | 30266825 | ||
| 414 | Phosphorylation | SAGPEQQQPPLEPDA CCCCCCCCCCCCCCH | 25849741 | ||
| 414 (in isoform 4) | Phosphorylation | - | 25849741 | ||
| 416 | Phosphorylation | GPEQQQPPLEPDAER CCCCCCCCCCCCHHH | - | ||
| 419 | Phosphorylation | QQQPPLEPDAERDAG CCCCCCCCCHHHCCC | 25262027 | ||
| 425 | Phosphorylation | EPDAERDAGPEQAQT CCCHHHCCCHHHHHH | - | ||
| 425 (in isoform 4) | Phosphorylation | - | - | ||
| 426 | Phosphorylation | PDAERDAGPEQAQTS CCHHHCCCHHHHHHH | - | ||
| 426 (in isoform 4) | Phosphorylation | - | - | ||
| 432 | Phosphorylation | AGPEQAQTSYRDLWS CCHHHHHHHHHHHHH | 27732954 | ||
| 433 | Phosphorylation | GPEQAQTSYRDLWSL CHHHHHHHHHHHHHH | 27732954 | ||
| 434 | Phosphorylation | PEQAQTSYRDLWSLR HHHHHHHHHHHHHHH | 27732954 | ||
| 436 (in isoform 4) | Phosphorylation | - | 29514088 | ||
| 439 | Phosphorylation | TSYRDLWSLRASLEL HHHHHHHHHHHHHHH | 24719451 | ||
| 439 (in isoform 4) | Phosphorylation | - | 29514088 | ||
| 440 (in isoform 4) | Phosphorylation | - | 30266825 | ||
| 443 | Phosphorylation | DLWSLRASLELHAAA HHHHHHHHHHHHHHH | 20068231 | ||
| 444 | Phosphorylation | LWSLRASLELHAAAS HHHHHHHHHHHHHHC | - | ||
| 444 (in isoform 4) | Phosphorylation | - | 30266825 | ||
| 451 | Phosphorylation | LELHAAASDHSSSGN HHHHHHHCCCCCCCC | 20068231 | ||
| 454 | Phosphorylation | HAAASDHSSSGNDRD HHHHCCCCCCCCCCC | 20068231 | ||
| 455 | Phosphorylation | AAASDHSSSGNDRDS HHHCCCCCCCCCCCC | 20068231 | ||
| 456 | Phosphorylation | AASDHSSSGNDRDSV HHCCCCCCCCCCCCC | 20068231 | ||
| 463 | Phosphorylation | SGNDRDSVRSGDSSG CCCCCCCCCCCCCCC | 20068231 | ||
| 471 | Phosphorylation | RSGDSSGSGSGGAAP CCCCCCCCCCCCCCC | 20068231 | ||
| 474 | Phosphorylation | DSSGSGSGGAAPAFP CCCCCCCCCCCCCCC | 20068231 | ||
| 475 | Phosphorylation | SSGSGSGGAAPAFPP CCCCCCCCCCCCCCC | 20068231 | ||
| 476 | Phosphorylation | SGSGSGGAAPAFPPP CCCCCCCCCCCCCCC | 20068231 | ||
| 484 | Phosphorylation | APAFPPPSPPAPRPK CCCCCCCCCCCCCCC | 24076635 | ||
| 503 | Phosphorylation | RRLLQMDSGYASIEG HHHEEECCCCCCCCC | 28442448 | ||
| 505 | Phosphorylation | LLQMDSGYASIEGRG HEEECCCCCCCCCCC | 28442448 | ||
| 507 | Phosphorylation | QMDSGYASIEGRGAG EECCCCCCCCCCCCC | 26471730 | ||
| 517 | Phosphorylation | GRGAGDDTEPPAAPA CCCCCCCCCCCCCCC | 23186163 | ||
| 527 | Phosphorylation | PAAPARPRSPRAWPR CCCCCCCCCCCCCCC | 23186163 | ||
| 528 | Phosphorylation | AAPARPRSPRAWPRR CCCCCCCCCCCCCCC | 22617229 | ||
| 540 | Phosphorylation | PRRPRRDYSIDEKTD CCCCCCCCCCCHHHH | 23312004 | ||
| 541 | Phosphorylation | RRPRRDYSIDEKTDA CCCCCCCCCCHHHHH | 23312004 | ||
| 548 | Phosphorylation | SIDEKTDALFHEFLR CCCHHHHHHHHHHHH | 23917254 | ||
| 561 | Phosphorylation | LRHDPHFDDTPAAAR HHCCCCCCCCHHHHH | 24961811 | ||
| 563 | Phosphorylation | HDPHFDDTPAAARHR CCCCCCCCHHHHHHH | 29214152 | ||
| 601 | Phosphorylation | AAPALAGTPAPPAGA CCHHHCCCCCCCCCC | 28555341 | ||
| 621 | Phosphorylation | APLRRGDSVDGPPDG CCCCCCCCCCCCCCC | 29255136 | ||
| 641 | Phosphorylation | AGDDPAIPVIEEEPG CCCCCCCCEEECCCC | 25849741 | ||
| 689 | Phosphorylation | LAEPVVATPALVAAA HCCCEECCHHHHHCC | 27732954 | ||
| 698 | Phosphorylation | ALVAAAPTSPDHSPA HHHHCCCCCCCCCCC | 30266825 | ||
| 699 | Phosphorylation | LVAAAPTSPDHSPA- HHHCCCCCCCCCCC- | 30266825 | ||
| 703 | Phosphorylation | APTSPDHSPA----- CCCCCCCCCC----- | 30266825 | ||
| 718 | Phosphorylation | -------------------- -------------------- | 20068231 | ||
| 719 | Phosphorylation | --------------------- --------------------- | 18669648 | ||
| 723 | Phosphorylation | ------------------------- ------------------------- | 20363803 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CBARP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CBARP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CBARP_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CBARP_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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