| UniProt ID | TPTE2_HUMAN | |
|---|---|---|
| UniProt AC | Q6XPS3 | |
| Protein Name | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 | |
| Gene Name | TPTE2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 522 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . Isoform 4: Cytoplasm. |
|
| Protein Description | ||
| Protein Sequence | MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Phosphorylation | EEAPAKESPHTSEFK CCCCCCCCCCCCCCC | 22.67 | - | |
| 35 | Phosphorylation | FKGAALVSPISKSML CCCCEECCCCCHHHH | 19.84 | 25159151 | |
| 38 (in isoform 4) | Phosphorylation | - | 23.28 | 22468782 | |
| 66 (in isoform 3) | Phosphorylation | - | 2.60 | 24043423 | |
| 71 (in isoform 3) | Phosphorylation | - | 4.37 | 24043423 | |
| 73 (in isoform 3) | Phosphorylation | - | 15.08 | 24043423 | |
| 75 (in isoform 3) | Phosphorylation | - | 12.05 | 24043423 | |
| 96 (in isoform 3) | Phosphorylation | - | 3.44 | 24043423 | |
| 103 (in isoform 2) | Phosphorylation | - | 12.29 | 24043423 | |
| 108 (in isoform 2) | Phosphorylation | - | 19.83 | 24043423 | |
| 110 (in isoform 2) | Phosphorylation | - | 18.67 | 24043423 | |
| 112 (in isoform 2) | Phosphorylation | - | 17.00 | 24043423 | |
| 133 (in isoform 2) | Phosphorylation | - | 53.86 | 24043423 | |
| 135 | Phosphorylation | FVEGRQQYFSDLFNI HHHCHHHHHHHHHHH | 9.19 | - | |
| 173 | Phosphorylation | LRNIPRWTHLVRLLR HHCCCHHHHHHHHHH | 13.45 | - | |
| 235 | Phosphorylation | IIAMSFPSSGRQSFY EEEEECCCCCCCCCC | 43.33 | 28064214 | |
| 327 | Phosphorylation | CKGGKGRTGTMVCAL EECCCCHHHHHHHHH | 45.75 | - | |
| 338 | Phosphorylation | VCALLIASEIFLTAE HHHHHHHHHHHHCHH | 25.00 | - | |
| 404 | Phosphorylation | FIKRFIIYSIRGDVC EEEEEHHHHCCCCCC | 8.01 | 19664994 | |
| 405 | Phosphorylation | IKRFIIYSIRGDVCD EEEEHHHHCCCCCCC | 8.73 | 24719451 | |
| 411 | S-nitrosylation | YSIRGDVCDLKVQVV HHCCCCCCCEEEEEE | 6.37 | 24105792 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TPTE2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TPTE2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TPTE2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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