DSCAM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DSCAM_HUMAN
• UniProt AC: O60469
• Protein Name: Down syndrome cell adhesion molecule
• Gene Name: DSCAM
• Organism: Homo sapiens (Human).
• Sequence Length: 2012
• Subcellular Localization: Isoform Short: Secreted .; Isoform Long: Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell junction, synapse . Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
• Protein Description: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. [PubMed: 10925149 Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding]
• Protein Sequence: MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	N-linked_Glycosylation	HSSLYFVNASLQEVV HHHHHEEECCCEEEE	17.57	UniProtKB CARBOHYD
78	N-linked_Glycosylation	GIRHVHPNGTLQIFP CCCEECCCCCEEEEE	41.00	UniProtKB CARBOHYD
113	Phosphorylation	NPSGKIRSQDVHIKA CCCCCCCCCCEEEEE	33.92	-
119	Ubiquitination	RSQDVHIKAVLREPY CCCCEEEEEEECCCE	19.98	-
135	Phosphorylation	VRVEDQKTMRGNVAV EEECCCCCCCCCEEE	13.38	-
176	Phosphorylation	SGSRFLITSTGALYI ECCEEEEECCCCEEE	23.53	29083192
177	Phosphorylation	GSRFLITSTGALYIK CCEEEEECCCCEEEE	20.18	29083192
178	Phosphorylation	SRFLITSTGALYIKD CEEEEECCCCEEEEE	20.16	29083192
182	Phosphorylation	ITSTGALYIKDVQNE EECCCCEEEEECCCC	12.85	29083192
274	Phosphorylation	LSGRFQKTVTGLLIE ECHHHHHHEEEEEEE	16.71	24043423
276	Phosphorylation	GRFQKTVTGLLIENI HHHHHHEEEEEEECC	27.61	24043423
414	Phosphorylation	PKIISAFSEKVVSPA CCEEEECCCCCCCCC	35.90	24719451
452	Phosphorylation	DPILKGGSHRISQMI CCCCCCCCEEEEEEE	20.47	23403867
456	Phosphorylation	KGGSHRISQMITSEG CCCCEEEEEEEECCC	17.41	23403867
460	Phosphorylation	HRISQMITSEGNVVS EEEEEEEECCCCEEE	18.51	23403867
461	Phosphorylation	RISQMITSEGNVVSY EEEEEEECCCCEEEE	32.36	23403867
467	Phosphorylation	TSEGNVVSYLNISSS ECCCCEEEEEEECCC	21.44	23403867
470	N-linked_Glycosylation	GNVVSYLNISSSQVR CCEEEEEEECCCCEE	24.70	UniProtKB CARBOHYD
485	Phosphorylation	DGGVYRCTANNSAGV CCCEEEEECCCCCCE	24.34	21712546
487	N-linked_Glycosylation	GVYRCTANNSAGVVL CEEEEECCCCCCEEE	25.49	UniProtKB CARBOHYD
495	Phosphorylation	NSAGVVLYQARINVR CCCCEEEEEEEEECC	6.63	21712546
512	N-linked_Glycosylation	ASIRPMKNITAIAGR CCCCCCCCEEEEECC	30.50	UniProtKB CARBOHYD
530	Phosphorylation	IHCRVIGYPYYSIKW EEEEECCCCEEEEEE	4.12	-
532	Phosphorylation	CRVIGYPYYSIKWYK EEECCCCEEEEEEEE	11.02	-
533	Phosphorylation	RVIGYPYYSIKWYKN EECCCCEEEEEEEEC	10.22	-
534	Phosphorylation	VIGYPYYSIKWYKNS ECCCCEEEEEEEECC	16.32	24719451
556	N-linked_Glycosylation	RQVAFENNGTLKLSD CEEEEECCCEEEEHH	37.31	UniProtKB CARBOHYD
560	Acetylation	FENNGTLKLSDVQKE EECCCEEEEHHHEEE	45.87	7934559
658	N-linked_Glycosylation	TSSLRISNLSLMHNG CCCEEECCEEEEECC	31.14	UniProtKB CARBOHYD
666	N-linked_Glycosylation	LSLMHNGNYTCIARN EEEEECCCEEEEEEC	33.97	UniProtKB CARBOHYD
703	Phosphorylation	PRDQDGIYGKAVILN CCCCCCCCCEEEEEE	20.36	-
710	N-linked_Glycosylation	YGKAVILNCSAEGYP CCEEEEEECCCCCCC	13.43	UniProtKB CARBOHYD
748	N-linked_Glycosylation	GRIQVLSNGSLLIKH CEEEEEECCCEEEEE	39.65	UniProtKB CARBOHYD
769	Phosphorylation	GYYLCKVSNDVGADV CEEEEEEECCCCCCC	16.89	-
781	Phosphorylation	ADVSKSMYLTVKIPA CCCCHHCEEEEEECE	13.30	21214269
793	Phosphorylation	IPAMITSYPNTTLAT ECEEEECCCCCEECC	7.58	26503892
795	N-linked_Glycosylation	AMITSYPNTTLATQG EEEECCCCCEECCCC	37.15	UniProtKB CARBOHYD
796	Phosphorylation	MITSYPNTTLATQGQ EEECCCCCEECCCCC	20.77	26503892
797	Phosphorylation	ITSYPNTTLATQGQK EECCCCCEECCCCCC	22.49	21214269
848	Phosphorylation	EVGEEVISTLQILPT HHHHHHHHHHEECCC	28.39	-
860	Phosphorylation	LPTVREDSGFFSCHA CCCCCCCCCCEEEEE	32.52	-
864	Phosphorylation	REDSGFFSCHAINSY CCCCCCEEEEEECCC	11.61	28634120
870	Phosphorylation	FSCHAINSYGEDRGI EEEEEECCCCCCCEE	28.53	28634120
924	N-linked_Glycosylation	GYDIECKNKSDSWDS EEEEEECCCCCCCCC	61.80	UniProtKB CARBOHYD
928	Phosphorylation	ECKNKSDSWDSAQRT EECCCCCCCCCHHHH	39.61	30576142
931	Phosphorylation	NKSDSWDSAQRTKDV CCCCCCCCHHHHCCC	21.75	-
935	Phosphorylation	SWDSAQRTKDVSPQL CCCCHHHHCCCCCCC	21.37	-
957	Phosphorylation	IHPSSTYSIRMYAKN ECCCCCCEEEEEEEC	12.10	24719451
1142	N-linked_Glycosylation	GELGEIKNITTTQPS CCCCCEECCEECCCC	42.36	UniProtKB CARBOHYD
1160	N-linked_Glycosylation	DGLEKYTNYSIQVLA CCHHHCCCCEEEEEE	26.01	UniProtKB CARBOHYD
1222	Phosphorylation	LNGIIRKYTVFCSHP ECCEEEEEEEECCCC	9.78	28634298
1223	Phosphorylation	NGIIRKYTVFCSHPY CCEEEEEEEECCCCC	15.33	28634298
1227	Phosphorylation	RKYTVFCSHPYPTVI EEEEEECCCCCCEEE	18.94	28634298
1230	Phosphorylation	TVFCSHPYPTVISEF EEECCCCCCEEEEEE	13.20	28634298
1232	Phosphorylation	FCSHPYPTVISEFEA ECCCCCCEEEEEEEC	25.32	28634298
1235	Phosphorylation	HPYPTVISEFEASPD CCCCEEEEEEECCCC	31.71	28634298
1240	Phosphorylation	VISEFEASPDSFSYR EEEEEECCCCCCEEE	23.26	28634298
1243	Phosphorylation	EFEASPDSFSYRIPN EEECCCCCCEEECCC	21.34	28634298
1245	Phosphorylation	EASPDSFSYRIPNLS ECCCCCCEEECCCCC	19.90	28634298
1246	Phosphorylation	ASPDSFSYRIPNLSR CCCCCCEEECCCCCC	15.56	28634298
1250	N-linked_Glycosylation	SFSYRIPNLSRNRQY CCEEECCCCCCCCCE	48.56	UniProtKB CARBOHYD
1271	N-linked_Glycosylation	VTSAGRGNSSEIITV EEECCCCCCCCEEEE	40.79	UniProtKB CARBOHYD
1323	Phosphorylation	AVKWMKDSNGTPSLV HHHCEECCCCCCCEE	31.47	30576142
1326	Phosphorylation	WMKDSNGTPSLVTID CEECCCCCCCEEEEC	17.60	30576142
1341	N-linked_Glycosylation	GRRSIFSNGSFIIRT CCEEECCCCCEEEEE	39.10	UniProtKB CARBOHYD
1343	Phosphorylation	RSIFSNGSFIIRTVK EEECCCCCEEEEEEE	19.95	30576142
1463	Phosphorylation	GVGPGRISEIIEAKT CCCCCHHHHHHHHHC	22.76	22210691
1488	N-linked_Glycosylation	QELFASINTTRVRLN HHHHHHCCCCEEEEE	32.66	UniProtKB CARBOHYD
1640	Phosphorylation	SLAEMLMSKNTRTSD HHHHHHHCCCCCCCH	20.84	23403867
1641 (in isoform 1)	Ubiquitination	-	48.66	21906983
1641	Ubiquitination	LAEMLMSKNTRTSDT HHHHHHCCCCCCCHH	48.66	2190698
1643	Phosphorylation	EMLMSKNTRTSDTLS HHHHCCCCCCCHHHH	38.78	23403867
1644	Methylation	MLMSKNTRTSDTLSK HHHCCCCCCCHHHHH	41.44	-
1645	Phosphorylation	LMSKNTRTSDTLSKQ HHCCCCCCCHHHHHH	28.99	28270605
1646	Phosphorylation	MSKNTRTSDTLSKQQ HCCCCCCCHHHHHHH	25.88	28270605
1648	Phosphorylation	KNTRTSDTLSKQQQT CCCCCCHHHHHHHHH	32.47	28270605
1650	Phosphorylation	TRTSDTLSKQQQTLR CCCCHHHHHHHHHHH	30.43	28270605
1803	Phosphorylation	RARSSMVSTESASST HHHHHCCCCHHHHHH	20.16	-
1891	Ubiquitination	VMNMAVPKAHRPGDL EEEEECCCCCCCCCC	50.67	-
1904	Phosphorylation	DLIHLPPYLRMDFLL CCCCCCCCCCHHHHH	12.66	22210691
1936	Phosphorylation	LEPQKSRTLKRPTVL CCCCCCCCCCCCCEE	43.66	-
1941	Phosphorylation	SRTLKRPTVLEPIPM CCCCCCCCEEECCCH	41.58	-
1953	Phosphorylation	IPMEAASSASSTREG CCHHHHCCCCCCCCC	27.69	22210691
1956	Phosphorylation	EAASSASSTREGQSW HHHCCCCCCCCCCCC	31.06	22210691
1986	Phosphorylation	LGQAAKMSSSQESLL HHHHHHCCCCHHHHH	26.57	24719451
1988	Phosphorylation	QAAKMSSSQESLLDS HHHHCCCCHHHHHHC	30.57	-
2005	Phosphorylation	HLKGNNPYAKSYTLV CCCCCCCCCCCEEEC	28.87	24719451
2008	Phosphorylation	GNNPYAKSYTLV--- CCCCCCCCEEEC---	18.38	22210691
2009	Phosphorylation	NNPYAKSYTLV---- CCCCCCCEEEC----	11.91	22210691
2010	Phosphorylation	NPYAKSYTLV----- CCCCCCEEEC-----	28.30	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DSCAM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DSCAM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DSCAM_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DSCAM_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.