HS3S1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HS3S1_HUMAN
• UniProt AC: O14792
• Protein Name: Heparan sulfate glucosamine 3-O-sulfotransferase 1
• Gene Name: HS3ST1
• Organism: Homo sapiens (Human).
• Sequence Length: 307
• Subcellular Localization: Golgi apparatus lumen .
• Protein Description: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site..
• Protein Sequence: MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Ubiquitination	GQQELLRKAGTLQDD CHHHHHHHHCCCCHH	51.65	21906983
48	N-linked_Glycosylation	VRDGVAPNGSAQQLP HHCCCCCCCCHHHCC	47.52	UniProtKB CARBOHYD
120	Phosphorylation	HQLTVEKTPAYFTSP CCCEEECCCCCCCCC	10.31	22985185
128	Ubiquitination	PAYFTSPKVPERVYS CCCCCCCCCCHHHHC	70.91	-
135	Phosphorylation	KVPERVYSMNPSIRL CCCHHHHCCCCCEEE	14.82	-
150	Phosphorylation	LLILRDPSERVLSDY EEEECCHHHHHHHHH	42.18	-
155	Phosphorylation	DPSERVLSDYTQVFY CHHHHHHHHHHHHHH	26.22	-
169	Ubiquitination	YNHMQKHKPYPSIEE HHHHHHCCCCCCHHH	53.97	-
189	Ubiquitination	GRLNVDYKALNRSLY CCCCCCHHHHHHHHH	41.77	21906983
192	N-linked_Glycosylation	NVDYKALNRSLYHVH CCCHHHHHHHHHHHH	36.03	UniProtKB CARBOHYD
242	N-linked_Glycosylation	LKLSPQINASNFYFN HHHCCCCCCCHHEEE	31.88	UniProtKB CARBOHYD
249	N-linked_Glycosylation	NASNFYFNKTKGFYC CCCHHEEECCCCEEE	39.44	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HS3S1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HS3S1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HS3S1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.