ZNRF3_HUMAN - dbPTM
ZNRF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZNRF3_HUMAN
UniProt AC Q9ULT6
Protein Name E3 ubiquitin-protein ligase ZNRF3
Gene Name ZNRF3
Organism Homo sapiens (Human).
Sequence Length 936
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone..
Protein Sequence MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
134UbiquitinationEQPELDPKPCLTVLG
CCCCCCCCCCEEHHH		48.29-
182PhosphorylationPLKRPVVYVKGADAI
CCCCCEEEEECHHHH		9.18-
261UbiquitinationLAVQALEKMETRKFN
HHHHHHHHHHHHHCC		42.77-
264PhosphorylationQALEKMETRKFNSKS
HHHHHHHHHHCCCCC		35.34-
278PhosphorylationSKGRREGSCGALDTL
CCCCCCCCCCCHHHC		12.4823312004
284PhosphorylationGSCGALDTLSSSSTS
CCCCCHHHCCCCCCC		29.4123312004
341UbiquitinationRHNIIEQKGNPSAVC
HHCHHHHCCCCCCEE		48.11-
408PhosphorylationRHGEQSLYSPQTPAY
CCCCCCCCCCCCCCC		24.4526356563
409PhosphorylationHGEQSLYSPQTPAYI
CCCCCCCCCCCCCCH		18.8026356563
412PhosphorylationQSLYSPQTPAYIRSY
CCCCCCCCCCCHHCC		17.1726356563
415PhosphorylationYSPQTPAYIRSYPPL
CCCCCCCCHHCCCCC		9.7026356563
440PhosphorylationCGLEHRAYSPAHPFR
CCCCCCCCCCCCCCC		18.3625884760
441PhosphorylationGLEHRAYSPAHPFRR
CCCCCCCCCCCCCCC		18.0228348404
452PhosphorylationPFRRPKLSGRSFSKA
CCCCCCCCCCCCCCH		37.9823312004
455PhosphorylationRPKLSGRSFSKAACF
CCCCCCCCCCCHHHH		37.0824719451
489PhosphorylationQEGQSPPSLAPRGPA
HCCCCCCCCCCCCCC		40.3124719451
594PhosphorylationRSSLSSDYDPFIYRS
HHHCCCCCCCCCEEC		27.71-
599PhosphorylationSDYDPFIYRSRSPCR
CCCCCCCEECCCCCC		11.69-
601PhosphorylationYDPFIYRSRSPCRAS
CCCCCEECCCCCCCH		21.8223312004
603PhosphorylationPFIYRSRSPCRASEA
CCCEECCCCCCCHHC		29.6023312004
608PhosphorylationSRSPCRASEAGGSGS
CCCCCCCHHCCCCCC		14.5023312004
613PhosphorylationRASEAGGSGSSGRGP
CCHHCCCCCCCCCCC		34.2923312004
615PhosphorylationSEAGGSGSSGRGPAL
HHCCCCCCCCCCCCC		31.1723312004
616PhosphorylationEAGGSGSSGRGPALC
HCCCCCCCCCCCCCC		35.7123312004
627PhosphorylationPALCFEGSPPPEELP
CCCCCCCCCCHHHCC		27.3424719451
680PhosphorylationLEHRGPNSSTSEVGL
CCCCCCCCCCCCCEE		37.8223312004
681PhosphorylationEHRGPNSSTSEVGLE
CCCCCCCCCCCCEEE		42.4623312004
682PhosphorylationHRGPNSSTSEVGLEA
CCCCCCCCCCCEEEE		28.8223312004
683PhosphorylationRGPNSSTSEVGLEAS
CCCCCCCCCCEEEEC		32.0323312004
690PhosphorylationSEVGLEASPGAAPDL
CCCEEEECCCCCCCH		17.9423312004
759PhosphorylationSGSSQGLYGLHPDHL
CCCCCCCCCCCCCCC		25.19-
769PhosphorylationHPDHLPRTDGVKYEG
CCCCCCCCCCCCCCC		34.8523312004
774PhosphorylationPRTDGVKYEGLPCCF
CCCCCCCCCCCCEEE		16.9023312004
782PhosphorylationEGLPCCFYEEKQVAR
CCCCEEEEEECEEEC		14.8423312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZNRF3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZNRF3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZNRF3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RSPO1_HUMANRSPO1physical
22575959
LGR4_HUMANLGR4physical
22575959
LGR4_HUMANLGR4physical
24165923
RSPO1_HUMANRSPO1physical
24165923
DVL2_HUMANDVL2physical
25891077
RSPO2_HUMANRSPO2physical
25504990
RSPO3_HUMANRSPO3physical
25504990
RSPO1_HUMANRSPO1physical
25504990
FZD7_HUMANFZD7physical
28600110
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZNRF3_HUMAN

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Related Literatures of Post-Translational Modification

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