CDX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDX1_HUMAN
• UniProt AC: P47902
• Protein Name: Homeobox protein CDX-1
• Gene Name: CDX1
• Organism: Homo sapiens (Human).
• Sequence Length: 265
• Subcellular Localization: Nucleus.
• Protein Description: Plays a role in transcriptional regulation. [PubMed: 24623306 Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells]
• Protein Sequence: MYVGYVLDKDSPVYPGPARPASLGLGPQAYGPPAPPPAPPQYPDFSSYSHVEPAPAPPTAWGAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAGPSLGGLCPSNTSLLATSSPMPVKEEFLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYVGYVLDK ------CCEEEEECC	11.55	-
5	Phosphorylation	---MYVGYVLDKDSP ---CCEEEEECCCCC	6.44	-
11	Phosphorylation	GYVLDKDSPVYPGPA EEEECCCCCCCCCCC	23.23	23312004
14	Phosphorylation	LDKDSPVYPGPARPA ECCCCCCCCCCCCCH	13.07	-
139	O-linked_Glycosylation	PYEWMRRSVAAGGGG CHHHHHHHHHCCCCC	13.02	30379171
148	Phosphorylation	AAGGGGGSGKTRTKD HCCCCCCCCCCCCCC	40.15	-
148	O-linked_Glycosylation	AAGGGGGSGKTRTKD HCCCCCCCCCCCCCC	40.15	30379171
185	Phosphorylation	YITIRRKSELAANLG EEEEEHHHHHHHHCC	35.71	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEBPA_HUMAN	CEBPA	physical	19059241
CABIN_HUMAN	CABIN1	physical	28514442
HIRA_HUMAN	HIRA	physical	28514442
DHX29_HUMAN	DHX29	physical	28514442
UBN2_HUMAN	UBN2	physical	28514442
TUT7_HUMAN	ZCCHC6	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
PUM2_HUMAN	PUM2	physical	28514442
KBTB6_HUMAN	KBTBD6	physical	28514442
ZN107_HUMAN	ZNF107	physical	28514442
CDK12_HUMAN	CDK12	physical	28514442
LIN41_HUMAN	TRIM71	physical	28514442
NO40_HUMAN	ZCCHC17	physical	28514442
ZN121_HUMAN	ZNF121	physical	28514442
PEO1_HUMAN	C10orf2	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
ELAV2_HUMAN	ELAVL2	physical	28514442
PARP2_HUMAN	PARP2	physical	28514442
SREK1_HUMAN	SREK1	physical	28514442
NGRN_HUMAN	NGRN	physical	28514442
TRUB2_HUMAN	TRUB2	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
RBM23_HUMAN	RBM23	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
CLK2_HUMAN	CLK2	physical	28514442
YTDC1_HUMAN	YTHDC1	physical	28514442
PTCD1_HUMAN	PTCD1	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
DHX8_HUMAN	DHX8	physical	28514442
ASH1L_HUMAN	ASH1L	physical	28514442
CASC3_HUMAN	CASC3	physical	28514442
SDA1_HUMAN	SDAD1	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
RBBP6_HUMAN	RBBP6	physical	28514442
MTEF3_HUMAN	MTERF3	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
LAR1B_HUMAN	LARP1B	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
SRSF5_HUMAN	SRSF5	physical	28514442
ZFR_HUMAN	ZFR	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
ZN431_HUMAN	ZNF431	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442
SRSF1_HUMAN	SRSF1	physical	28514442
SAS10_HUMAN	UTP3	physical	28514442
SRRM1_HUMAN	SRRM1	physical	28514442
ZCHC3_HUMAN	ZCCHC3	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
STRBP_HUMAN	STRBP	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
ANKH1_HUMAN	ANKHD1	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
BMS1_HUMAN	BMS1	physical	28514442
RSBNL_HUMAN	RSBN1L	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.