dbPTM

ASH1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASH1L_HUMAN
UniProt AC	Q9NR48
Protein Name	Histone-lysine N-methyltransferase ASH1L
Gene Name	ASH1L
Organism	Homo sapiens (Human).
Sequence Length	2969
Subcellular Localization	Nucleus . Cell junction, tight junction . Chromosome . The relevance of tight junction localization is however unclear.
Protein Description	Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me)..
Protein Sequence	MDPRNTAMLGLGSDSEGFSRKSPSAISTGTLVSKREVELEKNTKEEEDLRKRNRERNIEAGKDDGLTDAQQQFSVKETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTTIKHPRKALKSGKMTDEKNEHCPSKRDPSKLYKKADDVAAIECQSEEVIRLHSQGENNPLSKKLSPVHSEMADYINATPSTLLGSRDPDLKDRALLNGGTSVTEKLAQLIATCPPSKSSKTKPKKLGTGTTAGLVSKDLIRKAGVGSVAGIIHKDLIKKPTISTAVGLVTKDPGKKPVFNAAVGLVNKDSVKKLGTGTTAVFINKNLGKKPGTITTVGLLSKDSGKKLGIGIVPGLVHKESGKKLGLGTVVGLVNKDLGKKLGSTVGLVAKDCAKKIVASSAMGLVNKDIGKKLMSCPLAGLISKDAINLKAEALLPTQEPLKASCSTNINNQESQELSESLKDSATSKTFEKNVVRQNKESILEKFSVRKEIINLEKEMFNEGTCIQQDSFSSSEKGSYETSKHEKQPPVYCTSPDFKMGGASDVSTAKSPFSAVGESNLPSPSPTVSVNPLTRSPPETSSQLAPNPLLLSSTTELIEEISESVGKNQFTSESTHLNVGHRSVGHSISIECKGIDKEVNDSKTTHIDIPRISSSLGKKPSLTSESSIHTITPSVVNFTSLFSNKPFLKLGAVSASDKHCQVAESLSTSLQSKPLKKRKGRKPRWTKVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMKNIGPPSFVDHDFLKRRLPKLSKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKRGRPKSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLESESDNHRSSSDFFESEDQLQDPDDLDDSHRPSVCSMSDLEMEPDKKITKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGILSGSPTSLAVLEQTAQQAAGSALGQILPPLLPSSASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHLHSRQGSMIQTLAMKKASKGRRRLSPPTLLPNSPSHLSELTSLKEATPSPISESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHVSLIPPETSTVLSSLKEKHKHKCKRRNHDYLSYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAGHLLLNPAKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSSEQPQVSMDTGSSRSVLESLKRYRFGKDAVGERYKHKEKHRCHMSCPHLSPSKSLINREEQWVHREPSESSPLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHTNLFTSAIGSCRVSNPNSSGRKKLTDSPGLFSAQDTSLNRLHRKESLPSNERAVQTLAGSQPTSDKPSQRPSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLVASGDDSVDSLLQRMVQNEDQEPMEKSIDAVIATASAPPSSSPGRSHSKDRTLGKPDSLLVPAVTSDSCNNSISLLSEKLTSSCSPHHIKRSVVEAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPELNRDEEGAALHLSPDTVTDVIEAVVQSVNLNPEHKKGLKRKGWLLEEQTRKKQKPLPEEEEQENNKSFNEAPVEIPSPSETPAKPSEPESTLQPVLSLIPREKKPPRPPKKKYQKAGLYSDVYKTTDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVVFFVSGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIRQKQEEVKHTSDNIHSASLYTRWNGICRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENIEVARAARLAQIFKEICDGIISYKDSSRQALAAPLLNLPPKKKNADYYEKISDPLDLITIEKQILTGYYKTVEAFDADMLKVFRNAEKYYGRKSPVGRDVCRLRKAYYNARHEASAQIDEIVGETASEADSSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGVKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKKDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAANEIPSLEEPEREGATANVSEGEKKTEESSQEPQSTCTPEERRHNQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLFIPENSFRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	TAMLGLGSDSEGFSR CCCCCCCCCCCCCCC	42.90	25159151
15	Phosphorylation	MLGLGSDSEGFSRKS CCCCCCCCCCCCCCC	41.12	-
19	Phosphorylation	GSDSEGFSRKSPSAI CCCCCCCCCCCCCCC	50.05	25627689
22	Phosphorylation	SEGFSRKSPSAISTG CCCCCCCCCCCCCCC	23.99	30266825
24	Phosphorylation	GFSRKSPSAISTGTL CCCCCCCCCCCCCCC	45.38	30266825
27	Phosphorylation	RKSPSAISTGTLVSK CCCCCCCCCCCCCCH	22.09	23927012
28	Phosphorylation	KSPSAISTGTLVSKR CCCCCCCCCCCCCHH	28.24	23927012
30	Phosphorylation	PSAISTGTLVSKREV CCCCCCCCCCCHHHH	24.87	23927012
33	Phosphorylation	ISTGTLVSKREVELE CCCCCCCCHHHHHHH	29.16	29449344
34	Sumoylation	STGTLVSKREVELEK CCCCCCCHHHHHHHC	45.13	28112733
67	Phosphorylation	AGKDDGLTDAQQQFS CCCCCCCCHHHHHHC	34.51	29978859
74	Phosphorylation	TDAQQQFSVKETNFS CHHHHHHCCCCCCCC	28.13	29978859
78	Phosphorylation	QQFSVKETNFSEGNL HHHCCCCCCCCCCCE	35.53	19664994
81	Phosphorylation	SVKETNFSEGNLKLK CCCCCCCCCCCEEEE	46.82	29978859
86	Ubiquitination	NFSEGNLKLKIGLQA CCCCCCEEEEEEEEC	52.30	29967540
94	Acetylation	LKIGLQAKRTKKPPK EEEEEECCCCCCCCC	47.87	25953088
148	Ubiquitination	DPSKLYKKADDVAAI CHHHHHHHHHCCEEE	43.41	29967540
167	Phosphorylation	EEVIRLHSQGENNPL HHHHHHHHCCCCCCC	44.46	-
176	Ubiquitination	GENNPLSKKLSPVHS CCCCCCHHCCCHHHH	66.47	29967540
179	Phosphorylation	NPLSKKLSPVHSEMA CCCHHCCCHHHHHHH	33.48	25159151
183	Phosphorylation	KKLSPVHSEMADYIN HCCCHHHHHHHHHHC	29.33	23663014
188	Phosphorylation	VHSEMADYINATPST HHHHHHHHHCCCHHH	6.12	29978859
192	Phosphorylation	MADYINATPSTLLGS HHHHHCCCHHHHCCC	17.18	23312004
194	Phosphorylation	DYINATPSTLLGSRD HHHCCCHHHHCCCCC	27.60	23312004
195	Phosphorylation	YINATPSTLLGSRDP HHCCCHHHHCCCCCC	27.49	23312004
199	Phosphorylation	TPSTLLGSRDPDLKD CHHHHCCCCCCCHHH	33.22	23312004
214	Phosphorylation	RALLNGGTSVTEKLA HHHHCCCCCHHHHHH	22.79	23532336
217	Phosphorylation	LNGGTSVTEKLAQLI HCCCCCHHHHHHHHH	27.46	23532336
219	Acetylation	GGTSVTEKLAQLIAT CCCCHHHHHHHHHHH	39.49	7661951
226	Phosphorylation	KLAQLIATCPPSKSS HHHHHHHHCCCCCCC	20.67	20860994
230	Phosphorylation	LIATCPPSKSSKTKP HHHHCCCCCCCCCCC	30.25	20860994
234	Acetylation	CPPSKSSKTKPKKLG CCCCCCCCCCCCCCC	68.60	7661961
239	Ubiquitination	SSKTKPKKLGTGTTA CCCCCCCCCCCCCHH	61.75	29967540
242	Phosphorylation	TKPKKLGTGTTAGLV CCCCCCCCCCHHHHH	41.62	20860994
244	Phosphorylation	PKKLGTGTTAGLVSK CCCCCCCCHHHHHCH	17.20	-
245	Phosphorylation	KKLGTGTTAGLVSKD CCCCCCCHHHHHCHH	21.77	20860994
250	Phosphorylation	GTTAGLVSKDLIRKA CCHHHHHCHHHHHHH	26.04	-
261	Phosphorylation	IRKAGVGSVAGIIHK HHHHCCCCHHHHHCH	13.34	-
285	Acetylation	TAVGLVTKDPGKKPV EEEEEEECCCCCCCC	55.22	25953088
312	Phosphorylation	VKKLGTGTTAVFINK HHHCCCCCEEEEECC	16.06	28258704
313	Phosphorylation	KKLGTGTTAVFINKN HHCCCCCEEEEECCC	23.36	28258704
323	Acetylation	FINKNLGKKPGTITT EECCCCCCCCCCEEE	59.99	26051181
329	Phosphorylation	GKKPGTITTVGLLSK CCCCCCEEEEEEEEC	18.44	-
335	Phosphorylation	ITTVGLLSKDSGKKL EEEEEEEECCCCCEE	39.19	24719451
336	Acetylation	TTVGLLSKDSGKKLG EEEEEEECCCCCEEE	56.75	26051181
338	Phosphorylation	VGLLSKDSGKKLGIG EEEEECCCCCEEECE	57.14	-
341	Acetylation	LSKDSGKKLGIGIVP EECCCCCEEECEEEC	56.31	26051181
358	Acetylation	VHKESGKKLGLGTVV EECCCCCCCCCCHHH	51.84	7851387
375	Acetylation	VNKDLGKKLGSTVGL CCHHHHHHHHCHHHH	57.17	19413330
375	Ubiquitination	VNKDLGKKLGSTVGL CCHHHHHHHHCHHHH	57.17	29967540
402	Ubiquitination	SAMGLVNKDIGKKLM HHHCCCCHHHHHHHH	43.15	17203973
406	Acetylation	LVNKDIGKKLMSCPL CCCHHHHHHHHCCCC	42.97	90513
406	Ubiquitination	LVNKDIGKKLMSCPL CCCHHHHHHHHCCCC	42.97	17203973
418	Phosphorylation	CPLAGLISKDAINLK CCCHHHCCHHHHCCC	29.53	24719451
425	Sumoylation	SKDAINLKAEALLPT CHHHHCCCCHHHCCC	39.43	28112733
425	Ubiquitination	SKDAINLKAEALLPT CHHHHCCCCHHHCCC	39.43	29967540
457	Ubiquitination	QELSESLKDSATSKT HHHHHHHHHHHHHHH	59.94	29967540
467	Ubiquitination	ATSKTFEKNVVRQNK HHHHHHHHHHHHCCH	51.34	29967540
474	Methylation	KNVVRQNKESILEKF HHHHHCCHHHHHHHH	44.49	-
474	Ubiquitination	KNVVRQNKESILEKF HHHHHCCHHHHHHHH	44.49	29967540
476	Phosphorylation	VVRQNKESILEKFSV HHHCCHHHHHHHHHH	33.80	24719451
480	Methylation	NKESILEKFSVRKEI CHHHHHHHHHHHHHH	39.22	-
480	Ubiquitination	NKESILEKFSVRKEI CHHHHHHHHHHHHHH	39.22	29967540
482	Phosphorylation	ESILEKFSVRKEIIN HHHHHHHHHHHHHHH	31.89	25850435
485	Ubiquitination	LEKFSVRKEIINLEK HHHHHHHHHHHHCHH	51.62	29967540
526	Phosphorylation	HEKQPPVYCTSPDFK CCCCCCEEECCCCCC	8.86	27251275
528	Phosphorylation	KQPPVYCTSPDFKMG CCCCEEECCCCCCCC	26.13	25850435
529	Phosphorylation	QPPVYCTSPDFKMGG CCCEEECCCCCCCCC	20.93	25159151
545	Phosphorylation	SDVSTAKSPFSAVGE CCCCCCCCCCCCCCC	28.81	27050516
548	Phosphorylation	STAKSPFSAVGESNL CCCCCCCCCCCCCCC	25.98	25159151
553	Phosphorylation	PFSAVGESNLPSPSP CCCCCCCCCCCCCCC	37.42	27732954
557	Phosphorylation	VGESNLPSPSPTVSV CCCCCCCCCCCCEEE	40.97	30278072
559	Phosphorylation	ESNLPSPSPTVSVNP CCCCCCCCCCEEECC	37.22	30576142
561	Phosphorylation	NLPSPSPTVSVNPLT CCCCCCCCEEECCCC	29.74	27732954
563	Phosphorylation	PSPSPTVSVNPLTRS CCCCCCEEECCCCCC	20.75	27732954
568	Phosphorylation	TVSVNPLTRSPPETS CEEECCCCCCCCCCC	30.29	27732954
570	Phosphorylation	SVNPLTRSPPETSSQ EECCCCCCCCCCCCC	39.30	26657352
574	Phosphorylation	LTRSPPETSSQLAPN CCCCCCCCCCCCCCC	39.18	30278072
575	Phosphorylation	TRSPPETSSQLAPNP CCCCCCCCCCCCCCC	17.90	30278072
576	Phosphorylation	RSPPETSSQLAPNPL CCCCCCCCCCCCCCC	36.31	30278072
617	Phosphorylation	HLNVGHRSVGHSISI EEECCCCCCCCCEEE	27.12	23312004
621	Phosphorylation	GHRSVGHSISIECKG CCCCCCCCEEEEEEC	16.47	23312004
623	Phosphorylation	RSVGHSISIECKGID CCCCCCEEEEEECCC	18.49	29978859
637	Ubiquitination	DKEVNDSKTTHIDIP CCCCCCCCCCEEEHH	61.37	29967540
639	Phosphorylation	EVNDSKTTHIDIPRI CCCCCCCCEEEHHHH	22.14	20860994
649	Phosphorylation	DIPRISSSLGKKPSL EHHHHHHHCCCCCCC	34.06	23403867
679	Acetylation	FTSLFSNKPFLKLGA HHHHCCCCCCEECCC	35.63	26051181
706	Phosphorylation	SLSTSLQSKPLKKRK HHCHHHCCCCCCCCC	41.35	24719451
730	Phosphorylation	VARSTCRSPKGLELE HHHHHCCCCCCCCCC	32.86	24719451
732	Ubiquitination	RSTCRSPKGLELERS HHHCCCCCCCCCCHH	76.89	29967540
739	Phosphorylation	KGLELERSELFKNVS CCCCCCHHHHHHCCC	29.31	22673903
776	Ubiquitination	FVDHDFLKRRLPKLS HCCHHHHHHHCCCCC	35.15	29967540
789	Phosphorylation	LSKSTAPSLALLADS CCCCCCCCHHHHCCC	24.66	-
796	Phosphorylation	SLALLADSEKPSHKS CHHHHCCCCCCCCCC	41.74	-
800	Phosphorylation	LADSEKPSHKSFATH HCCCCCCCCCCCCCH	55.40	-
825	Acetylation	DLLSDIYKPKRGRPK HHHHHHHCCCCCCCC	44.38	26051181
834	Ubiquitination	KRGRPKSKEMPQLEG CCCCCCCCCCCCCCC	65.25	-
844	Ubiquitination	PQLEGPPKRTLKIPA CCCCCCCCCCCCCCH	62.24	-
860	Ubiquitination	KVFSLQSKEEQEPPI HCCCCCCCCCCCCCC	52.92	29967540
882	Phosphorylation	PSFKQGLSVSPFPKK CCCCCCCCCCCCCCC	27.63	30266825
884	Phosphorylation	FKQGLSVSPFPKKRG CCCCCCCCCCCCCCC	19.90	30266825
899	Phosphorylation	RPKRQMRSPVKMKPP CCCCCCCCCCCCCCC	28.80	28102081
902	Acetylation	RQMRSPVKMKPPVLS CCCCCCCCCCCCCEE	44.59	7708551
904	Acetylation	MRSPVKMKPPVLSVA CCCCCCCCCCCEEEC	40.21	7708561
909	Phosphorylation	KMKPPVLSVAPFVAT CCCCCCEEECCEEEC	19.23	24667141
916	Phosphorylation	SVAPFVATESPSKLE EECCEEECCCHHHCC	31.52	30576142
918	Phosphorylation	APFVATESPSKLESE CCEEECCCHHHCCCC	30.07	25159151
920	Phosphorylation	FVATESPSKLESESD EEECCCHHHCCCCCC	60.18	20068231
981	Phosphorylation	NNGQLMKTIIRKINK CCCHHHHHHHHHHHH	13.99	28258704
996	Ubiquitination	MKTLKRKKLLNQILS CCHHHHHHHHHHHHH	63.34	29967540
1003	Phosphorylation	KLLNQILSSSVESSN HHHHHHHHHCHHHCC	23.38	26074081
1004	Phosphorylation	LLNQILSSSVESSNK HHHHHHHHCHHHCCC	34.65	26074081
1005	Phosphorylation	LNQILSSSVESSNKG HHHHHHHCHHHCCCC	26.91	26074081
1008	Phosphorylation	ILSSSVESSNKGKVQ HHHHCHHHCCCCHHH	36.74	26074081
1009	Phosphorylation	LSSSVESSNKGKVQS HHHCHHHCCCCHHHH	29.11	26074081
1011	Ubiquitination	SSVESSNKGKVQSKL HCHHHCCCCHHHHHH	63.16	29967540
1016	Phosphorylation	SNKGKVQSKLHNTVS CCCCHHHHHHHHHHH	39.92	26074081
1021	Phosphorylation	VQSKLHNTVSSLAAT HHHHHHHHHHHHHHH	15.83	29759185
1028	Phosphorylation	TVSSLAATFGSKLGQ HHHHHHHHHHHHHHC	23.95	22617229
1031	Phosphorylation	SLAATFGSKLGQQIN HHHHHHHHHHHCEEE	22.10	29759185
1032	Acetylation	LAATFGSKLGQQINV HHHHHHHHHHCEEEC	57.95	26051181
1041	Ubiquitination	GQQINVSKKGTIYIG HCEEECCCCCEEEEC	51.44	29967540
1042	Acetylation	QQINVSKKGTIYIGK CEEECCCCCEEEECC	54.50	30587067
1162	Phosphorylation	SKGRRRLSPPTLLPN HCCCCCCCCCCCCCC	27.33	29255136
1165	Phosphorylation	RRRLSPPTLLPNSPS CCCCCCCCCCCCCHH	44.29	23663014
1170	Phosphorylation	PPTLLPNSPSHLSEL CCCCCCCCHHHHHHH	26.32	30278072
1172	Phosphorylation	TLLPNSPSHLSELTS CCCCCCHHHHHHHHC	36.56	23663014
1175	Phosphorylation	PNSPSHLSELTSLKE CCCHHHHHHHHCCCC	25.74	28450419
1178	Phosphorylation	PSHLSELTSLKEATP HHHHHHHHCCCCCCC	28.14	23663014
1179	Phosphorylation	SHLSELTSLKEATPS HHHHHHHCCCCCCCC	50.50	23663014
1186	Phosphorylation	SLKEATPSPISESHS CCCCCCCCCCCCCCC	30.43	25056879
1220	Methylation	RAEKFCGQKKRRHSF HHHHHCCCCCCCCCC	49.64	26797129
1226	Phosphorylation	GQKKRRHSFEHVSLI CCCCCCCCCCCCCCC	30.44	26657352
1231	Phosphorylation	RHSFEHVSLIPPETS CCCCCCCCCCCCCHH	23.61	29255136
1237	Phosphorylation	VSLIPPETSTVLSSL CCCCCCCHHHHHHHH	35.16	24144214
1238	Phosphorylation	SLIPPETSTVLSSLK CCCCCCHHHHHHHHH	18.17	23312004
1239	Phosphorylation	LIPPETSTVLSSLKE CCCCCHHHHHHHHHH	32.65	23312004
1242	Phosphorylation	PETSTVLSSLKEKHK CCHHHHHHHHHHHHH	29.32	24719451
1243	Phosphorylation	ETSTVLSSLKEKHKH CHHHHHHHHHHHHHH	39.02	23312004
1251	Acetylation	LKEKHKHKCKRRNHD HHHHHHHHCCCCCCC	46.37	7972715
1253	Acetylation	EKHKHKCKRRNHDYL HHHHHHCCCCCCCCC	60.23	7972725
1296	Phosphorylation	AELEELISRLSEIRI HHHHHHHHHHHHCCC	39.53	24719451
1299	Phosphorylation	EELISRLSEIRITHR HHHHHHHHHCCCCCC	29.84	24719451
1328	Phosphorylation	RINFNSFYTHPSFPL EEECCCCCCCCCCCC	12.17	22210691
1332	Phosphorylation	NSFYTHPSFPLDPLH CCCCCCCCCCCCHHH	31.71	22210691
1404	Phosphorylation	GLGYYGRYPPTLYPP CCCCCCCCCCCCCCC	14.81	27642862
1409	Phosphorylation	GRYPPTLYPPPPSPS CCCCCCCCCCCCCCC	19.03	27642862
1414	Phosphorylation	TLYPPPPSPSFTTPL CCCCCCCCCCCCCCC	38.66	27642862
1416	Phosphorylation	YPPPPSPSFTTPLPP CCCCCCCCCCCCCCC	39.29	27642862
1418	Phosphorylation	PPPSPSFTTPLPPPS CCCCCCCCCCCCCCC	31.66	27642862
1419	Phosphorylation	PPSPSFTTPLPPPSY CCCCCCCCCCCCCCC	22.33	27642862
1425	Phosphorylation	TTPLPPPSYMHAGHL CCCCCCCCCCCCCHH	40.64	27642862
1426	Phosphorylation	TPLPPPSYMHAGHLL CCCCCCCCCCCCHHH	9.93	27642862
1438	Ubiquitination	HLLLNPAKYHKKKHK HHHHCHHHHHHHHHH	49.50	-
1441	Ubiquitination	LNPAKYHKKKHKLLR HCHHHHHHHHHHHHH	61.50	-
1454	Phosphorylation	LRQEAFLTTSRTPLL HHHHHHCCCCCCCCC	19.10	28122231
1455	Phosphorylation	RQEAFLTTSRTPLLS HHHHHCCCCCCCCCC	20.54	28122231
1456	Phosphorylation	QEAFLTTSRTPLLSM HHHHCCCCCCCCCCC	28.99	28122231
1458	Phosphorylation	AFLTTSRTPLLSMST HHCCCCCCCCCCCCC	20.32	28122231
1462	Phosphorylation	TSRTPLLSMSTYPSV CCCCCCCCCCCCCCC	20.54	28122231
1464	Phosphorylation	RTPLLSMSTYPSVPP CCCCCCCCCCCCCCH	22.78	28122231
1465	Phosphorylation	TPLLSMSTYPSVPPE CCCCCCCCCCCCCHH	30.70	28122231
1466	Phosphorylation	PLLSMSTYPSVPPEM CCCCCCCCCCCCHHH	6.04	28122231
1468	Phosphorylation	LSMSTYPSVPPEMAY CCCCCCCCCCHHHHH	36.52	28122231
1475	Phosphorylation	SVPPEMAYGWMVEHK CCCHHHHHHHHHHHH	15.26	28122231
1508	Dimethylation	SMDTGSSRSVLESLK CCCCCCCHHHHHHHH	32.26	-
1516	Dimethylation	SVLESLKRYRFGKDA HHHHHHHHHCCCCCC	32.90	-
1521	Acetylation	LKRYRFGKDAVGERY HHHHCCCCCCCCHHH	39.54	26051181
1521	Ubiquitination	LKRYRFGKDAVGERY HHHHCCCCCCCCHHH	39.54	33845483
1539	Phosphorylation	EKHRCHMSCPHLSPS CCCCCCCCCCCCCCC	10.79	23312004
1544	Phosphorylation	HMSCPHLSPSKSLIN CCCCCCCCCCHHHCC	24.88	28555341
1546	Phosphorylation	SCPHLSPSKSLINRE CCCCCCCCHHHCCHH	31.34	23312004
1626	Ubiquitination	PNSSGRKKLTDSPGL CCCCCCCCCCCCCCC	56.08	29967540
1628	Phosphorylation	SSGRKKLTDSPGLFS CCCCCCCCCCCCCCC	43.22	23401153
1630	Phosphorylation	GRKKLTDSPGLFSAQ CCCCCCCCCCCCCCC	18.68	30266825
1635	Phosphorylation	TDSPGLFSAQDTSLN CCCCCCCCCCCCCHH	30.02	29255136
1639	Phosphorylation	GLFSAQDTSLNRLHR CCCCCCCCCHHHHHC	24.04	24719451
1640	Phosphorylation	LFSAQDTSLNRLHRK CCCCCCCCHHHHHCC	31.75	24719451
1649	Phosphorylation	NRLHRKESLPSNERA HHHHCCCCCCCCHHH	48.92	20860994
1652	Phosphorylation	HRKESLPSNERAVQT HCCCCCCCCHHHHHH	57.53	28102081
1659	Phosphorylation	SNERAVQTLAGSQPT CCHHHHHHHCCCCCC	16.39	23312004
1663	Phosphorylation	AVQTLAGSQPTSDKP HHHHHCCCCCCCCCC	27.64	30108239
1666	Phosphorylation	TLAGSQPTSDKPSQR HHCCCCCCCCCCCCC	41.75	23663014
1667	Phosphorylation	LAGSQPTSDKPSQRP HCCCCCCCCCCCCCC	50.77	23663014
1671	Phosphorylation	QPTSDKPSQRPSEST CCCCCCCCCCCCCCC	44.56	25159151
1675	Phosphorylation	DKPSQRPSESTNCSP CCCCCCCCCCCCCCC	46.50	23663014
1677	Phosphorylation	PSQRPSESTNCSPTR CCCCCCCCCCCCCCC	29.29	29255136
1678	Phosphorylation	SQRPSESTNCSPTRK CCCCCCCCCCCCCCC	35.87	29255136
1681	Phosphorylation	PSESTNCSPTRKRSS CCCCCCCCCCCCCCC	31.23	29255136
1683	Phosphorylation	ESTNCSPTRKRSSSE CCCCCCCCCCCCCCC	32.31	29255136
1687	Phosphorylation	CSPTRKRSSSESTSS CCCCCCCCCCCCCCC	41.05	23927012
1688	Phosphorylation	SPTRKRSSSESTSST CCCCCCCCCCCCCCC	42.00	23927012
1689	Phosphorylation	PTRKRSSSESTSSTV CCCCCCCCCCCCCCC	36.49	25849741
1691	Phosphorylation	RKRSSSESTSSTVNG CCCCCCCCCCCCCCC	35.22	23927012
1692	Phosphorylation	KRSSSESTSSTVNGV CCCCCCCCCCCCCCC	23.73	25002506
1693	Phosphorylation	RSSSESTSSTVNGVP CCCCCCCCCCCCCCC	33.04	22210691
1694	Phosphorylation	SSSESTSSTVNGVPS CCCCCCCCCCCCCCC	36.14	28985074
1695	Phosphorylation	SSESTSSTVNGVPSR CCCCCCCCCCCCCCC	20.12	27251275
1701	Phosphorylation	STVNGVPSRSPRLVA CCCCCCCCCCCCEEE	42.88	23927012
1703	Phosphorylation	VNGVPSRSPRLVASG CCCCCCCCCCEEECC	20.79	25849741
1709	Phosphorylation	RSPRLVASGDDSVDS CCCCEEECCCCHHHH	34.96	30266825
1713	Phosphorylation	LVASGDDSVDSLLQR EEECCCCHHHHHHHH	32.34	30266825
1716	Phosphorylation	SGDDSVDSLLQRMVQ CCCCHHHHHHHHHHH	28.91	23663014
1733	Phosphorylation	DQEPMEKSIDAVIAT CCCCHHHHCCEEEEC	16.64	30266825
1740	Phosphorylation	SIDAVIATASAPPSS HCCEEEECCCCCCCC	15.26	26657352
1742	Phosphorylation	DAVIATASAPPSSSP CEEEECCCCCCCCCC	36.63	30266825
1746	Phosphorylation	ATASAPPSSSPGRSH ECCCCCCCCCCCCCC	42.25	30266825
1747	Phosphorylation	TASAPPSSSPGRSHS CCCCCCCCCCCCCCC	46.45	30266825
1748	Phosphorylation	ASAPPSSSPGRSHSK CCCCCCCCCCCCCCC	35.39	30266825
1752	Phosphorylation	PSSSPGRSHSKDRTL CCCCCCCCCCCCCCC	37.72	30576142
1754	Phosphorylation	SSPGRSHSKDRTLGK CCCCCCCCCCCCCCC	37.18	21712546
1783	Phosphorylation	NNSISLLSEKLTSSC CCHHHHHHHHHHCCC	37.67	24719451
1787	Phosphorylation	SLLSEKLTSSCSPHH HHHHHHHHCCCCHHH	29.66	23927012
1788	Phosphorylation	LLSEKLTSSCSPHHI HHHHHHHCCCCHHHH	39.52	25849741
1789	Phosphorylation	LSEKLTSSCSPHHIK HHHHHHCCCCHHHHH	17.24	25159151
1791	Phosphorylation	EKLTSSCSPHHIKRS HHHHCCCCHHHHHHH	29.26	25849741
1828	Ubiquitination	KNLDHVNKILKAKKL CCHHHHHHHHHHHHH	48.61	29967540
1847	Acetylation	RTGNNFVKRRPGRPR HCCCCCCCCCCCCCC	38.25	26051181
1889	Phosphorylation	EGAALHLSPDTVTDV CCCCCCCCHHHHHHH	15.24	27732954
1892	Phosphorylation	ALHLSPDTVTDVIEA CCCCCHHHHHHHHHH	28.79	27732954
1894	Phosphorylation	HLSPDTVTDVIEAVV CCCHHHHHHHHHHHH	27.00	27732954
1917	Ubiquitination	HKKGLKRKGWLLEEQ HHHHHHHHCCHHHHH	53.50	29967540
1943	Phosphorylation	EEQENNKSFNEAPVE HHHHHCCCCCCCCCC	35.11	25159151
1953	Phosphorylation	EAPVEIPSPSETPAK CCCCCCCCCCCCCCC	46.87	28387310
1955	Phosphorylation	PVEIPSPSETPAKPS CCCCCCCCCCCCCCC	59.44	28387310
1957	Phosphorylation	EIPSPSETPAKPSEP CCCCCCCCCCCCCCC	32.65	28387310
1962	Phosphorylation	SETPAKPSEPESTLQ CCCCCCCCCCCCCCH	66.14	28102081
1966	Phosphorylation	AKPSEPESTLQPVLS CCCCCCCCCCHHHHH	45.17	28102081
1967	Phosphorylation	KPSEPESTLQPVLSL CCCCCCCCCHHHHHC	27.96	28102081
1973	Phosphorylation	STLQPVLSLIPREKK CCCHHHHHCCCCCCC	25.20	28102081
1989	Phosphorylation	PRPPKKKYQKAGLYS CCCCCHHHHHCCCCC	24.91	-
1995	Phosphorylation	KYQKAGLYSDVYKTT HHHHCCCCCCHHHCC	11.25	28152594
1996	Phosphorylation	YQKAGLYSDVYKTTD HHHCCCCCCHHHCCC	26.16	28152594
1999	Phosphorylation	AGLYSDVYKTTDPKS CCCCCCHHHCCCCHH	13.96	28152594
2000	Ubiquitination	GLYSDVYKTTDPKSR CCCCCHHHCCCCHHH	44.81	29967540
2081	Ubiquitination	YKKIRSNVYVDVKPL HHHHHCCCEEEEEEC	5.34	29967540
2095	Phosphorylation	LSGYEATTCNCKKPD CCCCCCEECCCCCCC	14.58	22210691
2282	Ubiquitination	CGFEKCRGIIGGKSQ CCCCCCCCCCCCCCC	25.90	29967540
2288	Phosphorylation	RGIIGGKSQRVNGLT CCCCCCCCCCCCCCC	26.88	29759185
2295	Phosphorylation	SQRVNGLTSSKNSQP CCCCCCCCCCCCCCC	32.14	29759185
2297	Phosphorylation	RVNGLTSSKNSQPMA CCCCCCCCCCCCCCC	30.53	29759185
2305	Phosphorylation	KNSQPMATHKKSGRS CCCCCCCCCCCCCCC	28.16	29759185
2317	Acetylation	GRSKEKRKSKHKLKK CCCHHHHHHHHHHHH	74.95	-
2319	Acetylation	SKEKRKSKHKLKKRR CHHHHHHHHHHHHHH	48.03	-
2323	Acetylation	RKSKHKLKKRRGHLS HHHHHHHHHHHCCCC	49.38	-
2334	Phosphorylation	GHLSEEPSENINTPT CCCCCCCCCCCCCCC	46.70	29978859
2339	Phosphorylation	EPSENINTPTRLTPQ CCCCCCCCCCCCCHH	23.41	25849741
2341	Phosphorylation	SENINTPTRLTPQLQ CCCCCCCCCCCHHHC	35.95	29255136
2385	Phosphorylation	QEEVKHTSDNIHSAS HHHHCCCCCCCCHHH	28.51	28555341
2390	Phosphorylation	HTSDNIHSASLYTRW CCCCCCCHHHHHHHC	18.76	28555341
2392	Phosphorylation	SDNIHSASLYTRWNG CCCCCHHHHHHHCCC	25.56	28555341
2427	Phosphorylation	QTARSVRTRRLAAAE HHHHHHHHHHHHHHH	20.27	-
2455	Ubiquitination	IFKEICDGIISYKDS HHHHHHHHHCCCCCC	18.08	29967540
2481	Ubiquitination	LPPKKKNADYYEKIS CCCCCCCCCHHHHCC	18.30	29967540
2502	Phosphorylation	TIEKQILTGYYKTVE HHHHHHHHCCHHHHH	25.43	29083192
2504	Phosphorylation	EKQILTGYYKTVEAF HHHHHHCCHHHHHHH	9.14	29083192
2505	Phosphorylation	KQILTGYYKTVEAFD HHHHHCCHHHHHHHC	11.09	29083192
2507	Phosphorylation	ILTGYYKTVEAFDAD HHHCCHHHHHHHCHH	13.88	29083192
2512	Ubiquitination	YKTVEAFDADMLKVF HHHHHHHCHHHHHHH	49.02	29967540
2544	Phosphorylation	CRLRKAYYNARHEAS HHHHHHHHHHHHHHH	13.75	25367160
2706	Ubiquitination	LDIFRIEKLWKNEKE CCEEEHHHHHCCCHH	58.22	-
2771	Ubiquitination	LYTYCKGRPKGVKEQ HHHHHCCCCCCCCCC	18.43	29967540
2781	Phosphorylation	GVKEQDVYICDYRLD CCCCCCEEEEEEEEC	12.24	22817900
2785	Phosphorylation	QDVYICDYRLDKSAH CCEEEEEEEECCCHH	14.52	22817900
2797	Phosphorylation	SAHLFYKIHRNRYPV CHHHHHHHHHCCCCE	2.22	18452278
2802	Phosphorylation	YKIHRNRYPVCTKPY HHHHHCCCCEECCCC	11.99	18452278
2804	Phosphorylation	IHRNRYPVCTKPYAF HHHCCCCEECCCCCC	4.86	18452278
2809	Phosphorylation	YPVCTKPYAFDHFPK CCEECCCCCCCCCCC	22.81	18452278
2817	Ubiquitination	AFDHFPKKLTPKKDF CCCCCCCCCCCCCCC	58.81	29967540
2825	Phosphorylation	LTPKKDFSPHYVPDN CCCCCCCCCCCCCCC	22.39	25159151
2828	Phosphorylation	KKDFSPHYVPDNYKR CCCCCCCCCCCCCCC	19.64	29214152
2890	Phosphorylation	EPEREGATANVSEGE CHHHCCCCCCCCCCC	29.62	23312004
2894	Phosphorylation	EGATANVSEGEKKTE CCCCCCCCCCCCCCC	39.43	23312004
2904	Phosphorylation	EKKTEESSQEPQSTC CCCCCCCCCCCCCCC	41.67	24825855
2910	Phosphorylation	SSQEPQSTCTPEERR CCCCCCCCCCHHHHH	18.36	28985074
2912	Phosphorylation	QEPQSTCTPEERRHN CCCCCCCCHHHHHHH	33.55	21712546
2951	Phosphorylation	TYLLEEGSGRKLRRR EEEECCCCCCCEECC	38.41	25159151
2959	Phosphorylation	GRKLRRRTLFIPENS CCCEECCEEECCCCC	24.98	28555341
2966	Phosphorylation	TLFIPENSFRK---- EEECCCCCCCC----	25.43	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ASH1L_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1220	Q	Methylation		26797129
Methylated at Gln-1220 by N6AMT1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASH1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
H31_HUMAN	HIST1H3A	physical	17923682
H31_HUMAN	HIST1H3A	physical	21239497

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASH1L_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1681, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1649, AND MASSSPECTROMETRY.	19007248 [Abstract]
Ubiquitylation
Reference	PubMed
"The proteomic reactor facilitates the analysis of affinity-purifiedproteins by mass spectrometry: application for identifyingubiquitinated proteins in human cells."; Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,Haines D.S., Figeys D.; J. Proteome Res. 6:298-305(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-402 AND LYS-406, AND MASSSPECTROMETRY.	17203973 [Abstract]

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