| UniProt ID | AVR2A_HUMAN | |
|---|---|---|
| UniProt AC | P27037 | |
| Protein Name | Activin receptor type-2A | |
| Gene Name | ACVR2A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 513 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).. | |
| Protein Sequence | MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 43 | N-linked_Glycosylation | NWEKDRTNQTGVEPC CCCCCCCCCCCCCCC | 38.01 | UniProtKB CARBOHYD | |
| 66 | N-linked_Glycosylation | HCFATWKNISGSIEI EEEEEEEECCCCEEE | 25.81 | UniProtKB CARBOHYD | |
| 68 | Phosphorylation | FATWKNISGSIEIVK EEEEEECCCCEEEEE | 35.56 | 24719451 | |
| 76 | Phosphorylation | GSIEIVKQGCWLDDI CCEEEEECCEECCCC | 41.19 | 32142685 | |
| 90 | Ubiquitination | INCYDRTDCVEKKDS CCCCCCCCCCCCCCC | 35.05 | 33845483 | |
| 118 | Ubiquitination | NEKFSYFPEMEVTQP CCCCCCCCCCEECCC | 31.62 | - | |
| 184 | Phosphorylation | DPGPPPPSPLLGLKP CCCCCCCCCCCCCCC | 33.67 | 27050516 | |
| 198 | Ubiquitination | PLQLLEVKARGRFGC CEEEEEEECCCCCCE | 24.00 | 33845483 | |
| 207 | Ubiquitination | RGRFGCVWKAQLLNE CCCCCEEEHHHHHCC | 8.37 | 29967540 | |
| 215 | Phosphorylation | KAQLLNEYVAVKIFP HHHHHCCEEEEEEEE | 7.82 | 29978859 | |
| 226 | Ubiquitination | KIFPIQDKQSWQNEY EEEECCCCCHHCCEE | 29.83 | 21906983 | |
| 233 | Phosphorylation | KQSWQNEYEVYSLPG CCHHCCEEEEEECCC | 20.46 | 69000261 | |
| 243 | Ubiquitination | YSLPGMKHENILQFI EECCCCCCCCHHHHH | 25.17 | 27667366 | |
| 254 | Ubiquitination | LQFIGAEKRGTSVDV HHHHCCCCCCCCCCH | 56.44 | - | |
| 315 | Ubiquitination | PGLKDGHKPAISHRD CCCCCCCCCCCCCCC | 41.49 | 29967540 | |
| 326 | Ubiquitination | SHRDIKSKNVLLKNN CCCCCCCCCEEECCC | 46.18 | - | |
| 351 | Ubiquitination | ALKFEAGKSAGDTHG EEEEECCCCCCCCCC | 44.15 | 27667366 | |
| 486 | Phosphorylation | ITQMQRLTNIITTED HHHHHHHHCCCCHHH | 26.93 | 46158809 | |
| 491 | Phosphorylation | RLTNIITTEDIVTVV HHHCCCCHHHCEEEE | 22.66 | 22210691 | |
| 496 | Phosphorylation | ITTEDIVTVVTMVTN CCHHHCEEEEEEEEC | 15.03 | 22210691 | |
| 499 | Phosphorylation | EDIVTVVTMVTNVDF HHCEEEEEEEECCCC | 11.11 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AVR2A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AVR2A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AVR2A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SYJ2B_HUMAN | SYNJ2BP | physical | 15451561 | |
| INHBA_HUMAN | INHBA | physical | 10746731 | |
| INHA_HUMAN | INHA | physical | 10746731 | |
| GDF5_HUMAN | GDF5 | physical | 8702914 | |
| BMP6_HUMAN | BMP6 | physical | 10504300 | |
| MAGI2_HUMAN | MAGI2 | physical | 15451561 | |
| IGSF1_HUMAN | IGSF1 | physical | 11266516 | |
| PEG10_HUMAN | PEG10 | physical | 15611116 | |
| INHBA_HUMAN | INHBA | physical | 8242742 | |
| ACVR1_HUMAN | ACVR1 | physical | 8242742 | |
| GDF2_HUMAN | GDF2 | physical | 22718755 | |
| BMP10_HUMAN | BMP10 | physical | 22718755 | |
| DAXX_HUMAN | DAXX | physical | 11483955 | |
| TSP50_HUMAN | PRSS50 | physical | 28650473 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| D09670 | Sotatercept (USAN/INN) | |||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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