| UniProt ID | GDF2_HUMAN | |
|---|---|---|
| UniProt AC | Q9UK05 | |
| Protein Name | Growth/differentiation factor 2 | |
| Gene Name | GDF2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 429 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.. | |
| Protein Sequence | MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 69 | Phosphorylation | VKVDFLRSLNLSGVP CCHHHHHHCCCCCCC | 24.61 | - | |
| 71 | N-linked_Glycosylation | VDFLRSLNLSGVPSQ HHHHHHCCCCCCCCC | 33.15 | UniProtKB CARBOHYD | |
| 102 | Phosphorylation | RYTSDKSTTPASNIV HHCCCCCCCCCHHHH | 42.41 | 22817900 | |
| 103 | Phosphorylation | YTSDKSTTPASNIVR HCCCCCCCCCHHHHH | 24.77 | 22817900 | |
| 136 | N-linked_Glycosylation | QKHILLFNISIPRHE CCEEEEEEEECCCHH | 27.37 | UniProtKB CARBOHYD | |
| 138 | Phosphorylation | HILLFNISIPRHEQI EEEEEEEECCCHHHC | 27.87 | 24719451 | |
| 243 | Phosphorylation | GCDTLDISVPPGSRN CCCEEEEECCCCCCC | 28.39 | 29083192 | |
| 248 | Phosphorylation | DISVPPGSRNLPFFV EEECCCCCCCCCEEE | 24.62 | 29083192 | |
| 263 | Phosphorylation | VFSNDHSSGTKETRL EEECCCCCCCHHHHH | 47.24 | - | |
| 277 | Phosphorylation | LELREMISHEQESVL HHHHHHHHHHHHHHH | 21.47 | - | |
| 293 | Phosphorylation | KLSKDGSTEAGESSH HHCCCCCCCCCCCCC | 35.07 | 18452278 | |
| 312 | Phosphorylation | DGHVAAGSTLARRKR CCCCCCCCHHHHHHH | 18.60 | 18452278 | |
| 399 | Phosphorylation | CCVPTKLSPISVLYK CCCCCCCCCCEEEEE | 23.03 | - | |
| 402 | Phosphorylation | PTKLSPISVLYKDDM CCCCCCCEEEEECCC | 14.95 | - | |
| 405 | Phosphorylation | LSPISVLYKDDMGVP CCCCEEEEECCCCCC | 15.37 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GDF2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GDF2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GDF2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GDF2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615506 | Telangiectasia, hereditary hemorrhagic, 5 (HHT5) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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