INHBA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INHBA_HUMAN
• UniProt AC: P08476
• Protein Name: Inhibin beta A chain
• Gene Name: INHBA
• Organism: Homo sapiens (Human).
• Sequence Length: 426
• Subcellular Localization: Secreted.
• Protein Description: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins..
• Protein Sequence: MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	O-linked_Glycosylation	TPGSEGHSAAPDCPS CCCCCCCCCCCCCCC	36.66	OGP
50	Phosphorylation	LPKDVPNSQPEMVEA CCCCCCCCCHHHHHH	40.83	29978859
50	O-linked_Glycosylation	LPKDVPNSQPEMVEA CCCCCCCCCHHHHHH	40.83	30379171
94	Ubiquitination	IRKLHVGKVGENGYV HHHCCCCCCCCCCCE	46.08	-
125	Phosphorylation	EQTSEIITFAESGTA HHHHHHHHHHHHCCC	23.58	29759185
129	Phosphorylation	EIITFAESGTARKTL HHHHHHHHCCCCEEE	37.71	25219547
131	Phosphorylation	ITFAESGTARKTLHF HHHHHHCCCCEEEEE	32.35	25219547
135	Phosphorylation	ESGTARKTLHFEISK HHCCCCEEEEEEEEC	21.66	29759185
141	Phosphorylation	KTLHFEISKEGSDLS EEEEEEEECCCCCCE	19.91	25219547
165	N-linked_Glycosylation	FLKVPKANRTRTKVT EEECCCCCCCCCEEE	52.57	UniProtKB CARBOHYD
172	Phosphorylation	NRTRTKVTIRLFQQQ CCCCCEEEEEHHHHC	11.26	24719451
188	Phosphorylation	HPQGSLDTGEEAEEV CCCCCCCCCHHHHHH	52.35	24961811
207	Phosphorylation	ERSELLLSEKVVDAR CHHEEHHEEEECCCC	35.03	24719451
226	Phosphorylation	HVFPVSSSIQRLLDQ EEEECCHHHHHHHHC	18.42	21406692
400	Phosphorylation	PTKLRPMSMLYYDDG CCCCCCCEEEEEECC	14.33	28270605
403	Phosphorylation	LRPMSMLYYDDGQNI CCCCEEEEEECCCCE	9.01	28270605
404	Phosphorylation	RPMSMLYYDDGQNII CCCEEEEEECCCCEE	12.00	28270605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INHBA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INHBA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INHBA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AVR2A_HUMAN	ACVR2A	physical	9202237
AVR2B_HUMAN	ACVR2B	physical	9202237
ACV1B_HUMAN	ACVR1B	physical	9202237

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.