IGSF1_HUMAN - dbPTM
IGSF1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IGSF1_HUMAN
UniProt AC Q8N6C5
Protein Name Immunoglobulin superfamily member 1
Gene Name IGSF1
Organism Homo sapiens (Human).
Sequence Length 1336
Subcellular Localization Isoform 1: Membrane
Multi-pass membrane protein .
Isoform 2: Membrane
Multi-pass membrane protein .
Isoform 3: Secreted .
Protein Description Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription..
Protein Sequence MTLDRPGEGATMLKTFTVLLFCIRMSLGMTSIVMDPQPELWIESNYPQAPWENITLWCRSPSRISSKFLLLKDKTQMTWIRPSHKTFQVSFLIGALTESNAGLYRCCYWKETGWSKPSKVLELEAPGQLPKPIFWIQAETPALPGCNVNILCHGWLQDLVFMLFKEGYAEPVDYQVPTGTMAIFSIDNLTPEDEGVYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKPTLTAHPGPIMAPGESLNLRCQGPIYGMTFALMRVEDLEKSFYHKKTIKNEANFFFQSLKIQDTGHYLCFYYDASYRGSLLSDVLKIWVTDTFPKTWLLARPSAVVQMGQNVSLRCRGPVDGVGLALYKKGEDKPLQFLDATSIDDNTSFFLNNVTYSDTGIYSCHYLLTWKTSIRMPSHNTVELMVVDKPPKPSLSAWPSTVFKLGKAITLQCRVSHPVLEFSLEWEERETFQKFSVNGDFIISNVDGKGTGTYSCSYRVETHPNIWSHRSEPLKLMGPAGYLTWNYVLNEAIRLSLIMQLVALLLVVLWIRWKCRRLRIREAWLLGTAQGVTMLFIVTALLCCGLCNGVLIEETEIVMPTPKPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRAAFPLGALTQSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASPTIRGQELQLRCKGWLAGMGFALYKEGEQEPVQQLGAVGREAFFTIQRMEDKDEGNYSCRTHTEKRPFKWSEPSEPLELVIKEMYPKPFFKTWASPVVTPGARVTFNCSTPHQHMSFILYKDGSEIASSDRSWASPGASAAHFLIISVGIGDGGNYSCRYYDFSIWSEPSDPVELVVTEFYPKPTLLAQPGPVVFPGKSVILRCQGTFQGMRFALLQEGAHVPLQFRSVSGNSADFLLHTVGAEDSGNYSCIYYETTMSNRGSYLSMPLMIWVTDTFPKPWLFAEPSSVVPMGQNVTLWCRGPVHGVGYILHKEGEATSMQLWGSTSNDGAFPITNISGTSMGRYSCCYHPDWTSSIKIQPSNTLELLVTGLLPKPSLLAQPGPMVAPGENMTLQCQGELPDSTFVLLKEGAQEPLEQQRPSGYRADFWMPAVRGEDSGIYSCVYYLDSTPFAASNHSDSLEIWVTDKPPKPSLSAWPSTMFKLGKDITLQCRGPLPGVEFVLEHDGEEAPQQFSEDGDFVINNVEGKGIGNYSCSYRLQAYPDIWSEPSDPLELVGAAGPVAQECTVGNIVRSSLIVVVVVALGVVLAIEWKKWPRLRTRGSETDGRDQTIALEECNQEGEPGTPANSPSSTSQRISVELPVPI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationELWIESNYPQAPWEN
HHEEECCCCCCCCCC		13.1522468782
53N-linked_GlycosylationYPQAPWENITLWCRS
CCCCCCCCEEEEECC		28.77UniProtKB CARBOHYD
60PhosphorylationNITLWCRSPSRISSK
CEEEEECCHHHCCCC		24.88-
62PhosphorylationTLWCRSPSRISSKFL
EEEECCHHHCCCCEE		43.4228972365
75PhosphorylationFLLLKDKTQMTWIRP
EEEECCCCCCEEECC		33.4322210691
78PhosphorylationLKDKTQMTWIRPSHK
ECCCCCCEEECCCCC		14.1222210691
168PhosphorylationFMLFKEGYAEPVDYQ
HHHHHCCCCCCCCEE		14.6426074081
174PhosphorylationGYAEPVDYQVPTGTM
CCCCCCCEECCCCCE		16.1926074081
178PhosphorylationPVDYQVPTGTMAIFS
CCCEECCCCCEEEEE		46.5626074081
180PhosphorylationDYQVPTGTMAIFSID
CEECCCCCEEEEEEC		13.1026074081
185PhosphorylationTGTMAIFSIDNLTPE
CCCEEEEEECCCCCC		23.9526074081
190PhosphorylationIFSIDNLTPEDEGVY
EEEECCCCCCCCCEE		30.7726074081
285PhosphorylationEANFFFQSLKIQDTG
CCCEEEEEEEEEECC		26.8624719451
309PhosphorylationSYRGSLLSDVLKIWV
HHCCCHHHHHHHHHC		30.8524719451
330PhosphorylationTWLLARPSAVVQMGQ
CEEEECCCEEEECCC		28.3024850871
338N-linked_GlycosylationAVVQMGQNVSLRCRG
EEEECCCCEEEEECC		21.44UniProtKB CARBOHYD
374N-linked_GlycosylationDATSIDDNTSFFLNN
ECCCCCCCCCEEECC		33.60UniProtKB CARBOHYD
381N-linked_GlycosylationNTSFFLNNVTYSDTG
CCCEEECCEEECCCC		29.65UniProtKB CARBOHYD
400PhosphorylationHYLLTWKTSIRMPSH
EEEEEECCEEECCCC		22.4322115753
401PhosphorylationYLLTWKTSIRMPSHN
EEEEECCEEECCCCC		12.4122115753
406PhosphorylationKTSIRMPSHNTVELM
CCEEECCCCCEEEEE		21.7422115753
409PhosphorylationIRMPSHNTVELMVVD
EECCCCCEEEEEEEC		15.2122115753
607N-linked_GlycosylationFPLAPWKNLTLWCRS
CCCCCCCCEEEEEEC		34.10UniProtKB CARBOHYD
691PhosphorylationPKPVISASPTIRGQE
CCCEECCCCCCCCCH		18.7824719451
747N-linked_GlycosylationMEDKDEGNYSCRTHT
CCCCCCCCCCCCCCC		24.40UniProtKB CARBOHYD
783PhosphorylationYPKPFFKTWASPVVT
CCCCCCEECCCCEEC		22.5525404012
786PhosphorylationPFFKTWASPVVTPGA
CCCEECCCCEECCCC		15.1325404012
790PhosphorylationTWASPVVTPGARVTF
ECCCCEECCCCEEEE		19.0825404012
798N-linked_GlycosylationPGARVTFNCSTPHQH
CCCEEEEECCCCCCE		14.95UniProtKB CARBOHYD
846N-linked_GlycosylationVGIGDGGNYSCRYYD
EECCCCCCCEEEEEE		30.95UniProtKB CARBOHYD
851PhosphorylationGGNYSCRYYDFSIWS
CCCCEEEEEEEEEEC		16.2418083107
937PhosphorylationHTVGAEDSGNYSCIY
EECCCCCCCCEEEEE		22.0523879269
939N-linked_GlycosylationVGAEDSGNYSCIYYE
CCCCCCCCEEEEEEE		29.51UniProtKB CARBOHYD
986N-linked_GlycosylationSVVPMGQNVTLWCRG
CEEECCCCEEEEECC		24.02UniProtKB CARBOHYD
1027N-linked_GlycosylationDGAFPITNISGTSMG
CCCEEEEECCCCCCC		27.44UniProtKB CARBOHYD
1082N-linked_GlycosylationPMVAPGENMTLQCQG
CEECCCCCEEEEEEC		34.35UniProtKB CARBOHYD
1147N-linked_GlycosylationSTPFAASNHSDSLEI
CCCCCCCCCCCCEEE		33.67UniProtKB CARBOHYD
1164PhosphorylationTDKPPKPSLSAWPST
ECCCCCCCCCCCCHH		40.8722210691
1166PhosphorylationKPPKPSLSAWPSTMF
CCCCCCCCCCCHHHE		32.4022210691
1171PhosphorylationSLSAWPSTMFKLGKD
CCCCCCHHHEECCCC		23.6522210691
1223N-linked_GlycosylationVEGKGIGNYSCSYRL
CCCCCCCCCCEEEEE		24.51UniProtKB CARBOHYD
1266PhosphorylationVGNIVRSSLIVVVVV
HHHHHHHHHHHHHHH		16.14-
1291PhosphorylationKKWPRLRTRGSETDG
HCCCCCCCCCCCCCC		43.9325999147
1294PhosphorylationPRLRTRGSETDGRDQ
CCCCCCCCCCCCCCC		33.7525849741
1296PhosphorylationLRTRGSETDGRDQTI
CCCCCCCCCCCCCEE		45.5125999147
1299PhosphorylationRGSETDGRDQTIALE
CCCCCCCCCCEEEEE		35.3627251275
1316PhosphorylationNQEGEPGTPANSPSS
CCCCCCCCCCCCCCC		29.9125849741
1329PhosphorylationSSTSQRISVELPVPI
CCCCCCEEEEECCCC		16.2430266825
1334PhosphorylationRISVELPVPI-----
CEEEEECCCC-----		11.8524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IGSF1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IGSF1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IGSF1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IGF1_HUMANIGF1physical
11344214
INHBA_HUMANINHBAphysical
11266516
INHBB_HUMANINHBBphysical
11266516
IGSF1_HUMANIGSF1physical
11266516
ACV1B_HUMANACVR1Bphysical
11266516
HECD1_HUMANHECTD1physical
12421765
RBP10_HUMANRANBP10physical
12421765
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300888Hypothyroidism, central, and testicular enlargement (CHTE)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IGSF1_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory