GDF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDF5_HUMAN
• UniProt AC: P43026
• Protein Name: Growth/differentiation factor 5
• Gene Name: GDF5
• Organism: Homo sapiens (Human).
• Sequence Length: 501
• Subcellular Localization: Secreted . Cell membrane .
• Protein Description: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. [PubMed: 24098149]
• Protein Sequence: MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRPGGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATARTVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	QATARTVTPKGQLPG CCCCEEECCCCCCCC	20.76	24719451
189	N-linked_Glycosylation	DADRKGGNSSVKLEA HHHHCCCCCCEEHHH	39.52	UniProtKB CARBOHYD
222	Phosphorylation	PVVRKQRYVFDISAL CCCCCEEEEEEHHHH	11.72	24719451
227	Phosphorylation	QRYVFDISALEKDGL EEEEEEHHHHHHCCC	28.75	29083192
249	Phosphorylation	LRKKPSDTAKPAAPG HHCCCCCCCCCCCCC	40.70	-
444	Phosphorylation	LRSHLEPTNHAVIQT CCCCCCCCCHHHHHH	30.20	28787133
451	Phosphorylation	TNHAVIQTLMNSMDP CCHHHHHHHHHCCCC	19.49	28787133
455	Phosphorylation	VIQTLMNSMDPESTP HHHHHHHCCCCCCCC	15.59	28787133
460	Phosphorylation	MNSMDPESTPPTCCV HHCCCCCCCCCCCCC	52.15	28787133
461	Phosphorylation	NSMDPESTPPTCCVP HCCCCCCCCCCCCCC	31.46	28787133
464	Phosphorylation	DPESTPPTCCVPTRL CCCCCCCCCCCCCCC	21.53	28787133
469	Phosphorylation	PPTCCVPTRLSPISI CCCCCCCCCCCCEEE	24.68	28787133
472	Phosphorylation	CCVPTRLSPISILFI CCCCCCCCCEEEEEE	19.52	-
475	Phosphorylation	PTRLSPISILFIDSA CCCCCCEEEEEEECC	19.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BMR1B_HUMAN	BMPR1B	physical	9525338
BMPR2_HUMAN	BMPR2	physical	9525338
BMR1A_HUMAN	BMPR1A	physical	9525338
TM102_HUMAN	TMEM102	physical	28514442
SNRK_HUMAN	SNRK	physical	28514442
RAB3I_HUMAN	RAB3IP	physical	28514442
FABP4_HUMAN	FABP4	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
R3GEF_HUMAN	RAB3IL1	physical	28514442
SPB7_HUMAN	SERPINB7	physical	28514442
PLCD1_HUMAN	PLCD1	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
CRYAB_HUMAN	CRYAB	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
KPRP_HUMAN	KPRP	physical	28514442
RABP2_HUMAN	CRABP2	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
SPB13_HUMAN	SERPINB13	physical	28514442
PAI2_HUMAN	SERPINB2	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.