MAGI2_HUMAN - dbPTM
MAGI2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAGI2_HUMAN
UniProt AC Q86UL8
Protein Name Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Gene Name MAGI2
Organism Homo sapiens (Human).
Sequence Length 1455
Subcellular Localization Cytoplasm. Late endosome. Cell junction, synapse, synaptosome. Cell membrane
Peripheral membrane protein. Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-a
Protein Description Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth..
Protein Sequence MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
220PhosphorylationGKRKRNKSVSNMEKA
HHHHCCCCCCCHHHC		34.0429514088
222PhosphorylationRKRNKSVSNMEKASI
HHCCCCCCCHHHCCC		37.2329514088
329PhosphorylationDHNTKTTSWLDPRLA
ECCCCCCCCCCHHHH		30.7628857561
362PhosphorylationEKIDDPIYGTYYVDH
EECCCCCCCEEECCC		14.5925884760
364PhosphorylationIDDPIYGTYYVDHIN
CCCCCCCEEECCCCC		8.4926356563
365PhosphorylationDDPIYGTYYVDHINR
CCCCCCEEECCCCCC		9.3426356563
366PhosphorylationDPIYGTYYVDHINRR
CCCCCEEECCCCCCC		10.152003211
547PhosphorylationGRHNYETYLEYISRT
CCCCHHHHHHHHHHC		5.898312505
622PhosphorylationFGFTIADSPTGQRVK
CCEEEECCCCCHHHH		18.494114527
624PhosphorylationFTIADSPTGQRVKQI
EEEECCCCCHHHHHH		50.3124076635
675PhosphorylationDCPIGSETSLIIHRG
CCCCCCCEEEEEECC		30.4546161093
676PhosphorylationCPIGSETSLIIHRGG
CCCCCCEEEEEECCC		17.3346161081
686PhosphorylationIHRGGFFSPWKTPKP
EECCCCCCCCCCCCC		27.8225307156
703PhosphorylationDRWENQGSPQTSLSA
HHHCCCCCCCCCCCC		12.2224076635
726PhosphorylationFPPALHRSSFPDSTE
CCCHHCCCCCCCCCC		26.1128857561
727PhosphorylationPPALHRSSFPDSTEA
CCHHCCCCCCCCCCC		40.5328857561
743PhosphorylationDPRKPDPYELYEKSR
CCCCCCHHHHHHHHH		26.4123663014
746PhosphorylationKPDPYELYEKSRAIY
CCCHHHHHHHHHHHH		14.9023663014
827PhosphorylationHPGDELVYVDGIPVA
CCCCEEEEECCEECC		12.87-
837PhosphorylationGIPVAGKTHRYVIDL
CEECCCCCHHHHHHH		15.6322210691
840PhosphorylationVAGKTHRYVIDLMHH
CCCCCHHHHHHHHHH		8.3122210691
875PhosphorylationPCPENGRSPGSVSTH
CCCCCCCCCCCCCCC		34.7027732954
878PhosphorylationENGRSPGSVSTHHSS
CCCCCCCCCCCCCCC		19.1127732954
880PhosphorylationGRSPGSVSTHHSSPR
CCCCCCCCCCCCCCC		24.5827732954
881PhosphorylationRSPGSVSTHHSSPRS
CCCCCCCCCCCCCCH		22.8127732954
884PhosphorylationGSVSTHHSSPRSDYA
CCCCCCCCCCCHHCC		34.1427732954
885PhosphorylationSVSTHHSSPRSDYAT
CCCCCCCCCCHHCCE		21.7027732954
1001PhosphorylationLIKDAGLSVTLRIIP
HHHHCCCEEEEEECC		16.4923403867
1003PhosphorylationKDAGLSVTLRIIPQE
HHCCCEEEEEECCHH		13.6220068231
1014PhosphorylationIPQEELNSPTSAPSS
CCHHHHCCCCCCCCC		42.03180151
1016PhosphorylationQEELNSPTSAPSSEK
HHHHCCCCCCCCCCC		37.0225307156
1037PhosphorylationQSPLAQQSPLAQPSP
CCCHHHCCCCCCCCC		15.1427251275
1043PhosphorylationQSPLAQPSPATPNSP
CCCCCCCCCCCCCCC		18.3227251275
1046PhosphorylationLAQPSPATPNSPIAQ
CCCCCCCCCCCCCCC		26.7927251275
1049PhosphorylationPSPATPNSPIAQPAP
CCCCCCCCCCCCCCC		20.9127251275
1106PhosphorylationRQPPGGDYQQPPPLD
CCCCCCCCCCCCCCC		16.6024927040
1160PhosphorylationGAKGFGFSIRGGREY
CCCCCCEEEECCCEE		16.269573121
1172PhosphorylationREYKMDLYVLRLAED
CEEEEEEEEEEECCC		7.9920068231
1206PhosphorylationGESTRDMTHARAIEL
CCCCCCCCHHHHHHH		19.3746161087
1215MethylationARAIELIKSGGRRVR
HHHHHHHHCCCCEEE		56.52-
1397PhosphorylationAGPGGGGSGALEAEG
CCCCCCCCCHHCCCC		24.9446161077
1426AcetylationPGGAPARKAAVAPGP
CCCCCCCCCCCCCCC		42.6971327
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAGI2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAGI2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAGI2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATN1_HUMANATN1physical
9647693
ADRB1_HUMANADRB1physical
11526121
CTNB1_HUMANCTNNB1physical
11526121
AGRB1_HUMANBAI1physical
23782696
TTBK1_HUMANTTBK1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAGI2_HUMAN

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Related Literatures of Post-Translational Modification

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