ADRB1_HUMAN - dbPTM
ADRB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADRB1_HUMAN
UniProt AC P08588
Protein Name Beta-1 adrenergic receptor
Gene Name ADRB1
Organism Homo sapiens (Human).
Sequence Length 477
Subcellular Localization Cell membrane
Multi-pass membrane protein. Early endosome. Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression..
Protein Description Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling..
Protein Sequence MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15N-linked_GlycosylationLGASEPGNLSSAAPL
ECCCCCCCCCCCCCC		47.68UniProtKB CARBOHYD
157PhosphorylationCVIALDRYLAITSPF
HHHHHHHHHHHCCCC		10.5168718167
168PhosphorylationTSPFRYQSLLTRARA
CCCCHHHHHHHHHHH		19.2024719451
260PhosphorylationKQVKKIDSCERRFLG
HHHHCCCCCCCCCCC		22.73178235603
274PhosphorylationGGPARPPSPSPSPVP
CCCCCCCCCCCCCCC		40.479412157
276PhosphorylationPARPPSPSPSPVPAP
CCCCCCCCCCCCCCC		42.2030631047
278PhosphorylationRPPSPSPSPVPAPAP
CCCCCCCCCCCCCCC		42.75178235609
312PhosphorylationRAGKRRPSRLVALRE
CCCCCCHHHHHHHHH		36.1114990580
357DimethylationHRELVPDRLFVFFNW
HHHHCCCCCHHHHHH		24.77-
392S-palmitoylationKAFQRLLCCARRAAR
HHHHHHHHHHHHHHH		1.7021464135
393S-palmitoylationAFQRLLCCARRAARR
HHHHHHHHHHHHHHH		3.1321464135
404PhosphorylationAARRRHATHGDRPRA
HHHHHHCCCCCCCCC		21.92178235599
412PhosphorylationHGDRPRASGCLARPG
CCCCCCCCCCCCCCC		31.17178235605
414S-palmitoylationDRPRASGCLARPGPP
CCCCCCCCCCCCCCC		2.1921464135
423PhosphorylationARPGPPPSPGAASDD
CCCCCCCCCCCCCCC		41.5616163541
428PhosphorylationPPSPGAASDDDDDDV
CCCCCCCCCCCCCCC		40.8333259812
461PhosphorylationGAAADSDSSLDEPCR
CCCCCCCCCCCCCCC		36.43178235601
462PhosphorylationAAADSDSSLDEPCRP
CCCCCCCCCCCCCCC		44.84178235607
475PhosphorylationRPGFASESKV-----
CCCCCCCCCC-----		35.9062021199
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
312SPhosphorylationKinasePRKACAP17612
GPS
312SPhosphorylationKinasePKA-Uniprot
412SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADRB1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADRB1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GIPC1_HUMANGIPC1physical
12724327
ARRB1_HUMANARRB1physical
10862778
MAGI2_HUMANMAGI2physical
11526121
ARRB1_HUMANARRB1physical
18787115
ARRB2_HUMANARRB2physical
18787115
GASP1_HUMANGPRASP1physical
15086532
GASP2_HUMANGPRASP2physical
15086532
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00076 Noradrenaline (JP16); Norepinephrine (INN); Nor adrenalin (TN)
D00095 Adrenaline (JP16); Epinephrine (USP/INN); Adrenalin (TN); Auvi-q (TN); Epipen (TN)
D00124 Ephedrine (USP); Ephedrine (TN)
D00235 Atenolol (JP16/USP/INN); Tenormin (TN)
D00255 Carvedilol (JAN/USAN/INN); Artist (TN); Coreg (TN)
D00378 Timolol (USAN); Timolol hemihydrate; Betimol (TN)
D00432 Nadolol (JP16/USP/INN); Corgard (TN)
D00483 Propranolol hydrochloride (JP16/USP); Inderal (TN); Innopran XL (TN)
D00485 Pseudoephedrine hydrochloride (USP); Sudafed (TN)
D00513 Pindolol (JP16/USP/INN); Blocklin-L (TN); Carvisken (TN); Visken (TN)
D00597 Acebutolol hydrochloride (JP16/USP); Sectral (TN)
D00598 Betaxolol hydrochloride (JP16/USP); Betoptic (TN); Kerlone (TN)
D00599 Carteolol hydrochloride (JP16/USP); Cartrol (TN); Ocupress (TN)
D00600 Labetalol hydrochloride (JP16/USP); Normodyne (TN); Trandate (TN)
D00601 Metoprolol tartrate (JP16/USP); Lopressor (TN)
D00602 Penbutolol sulfate (JP16/USP); Levatol (TN)
D00603 Timolol maleate (JP16/USP); Blocadren (TN); Istalol (TN); Timoptic (TN)
D00632 Dobutamine hydrochloride (JP16/USP); Dobutrex (TN)
D00634 Bisoprolol fumarate (JP16/USP); Zebeta (TN)
D00635 Metoprolol succinate (USP); Toprol XL (TN)
D00636 Amiodarone hydrochloride (JP16/USAN); Ancaron (TN); Cordarone (TN)
D00640 Propafenone hydrochloride (JP16/USP); Rythmol (TN)
D00644 Esmolol hydrochloride (JAN/USAN); Brevibloc (TN)
D00996 Epinephrine hydrochloride (JAN); Adrenalin chloride (TN)
D01017 Dipivefrin hydrochloride (JAN/USP); Propine (TN)
D01025 Levobunolol hydrochloride (JAN/USP); Betagan (TN)
D01026 Sotalol hydrochloride (JAN/USP); Betapace (TN); Sorine (TN)
D01182 Alprenolol hydrochloride (JP16/USAN); Regletin (TN)
D01369 Bevantolol hydrochloride (JAN/USAN); Calvan (TN); Vantol (TN)
D01386 Ephedrine hydrochloride (JP16/USP); Ephedrine hydrochloride (TN)
D01390 dl-Isoprenaline hydrochloride (JAN); Isoproterenol hydrochloride (USP); Isuprel (TN); Proternol-S (T
D01444 Bunitrolol hydrochloride (JAN); Betrilol (TN)
D01454 Bupranolol hydrochloride (JP16)
D01469 Amosulalol hydrochloride (JP16); Lowgan (TN)
D01471 Esatenolol (JAN/INN); (S)-Atenolol
D01504 Bufetolol hydrochloride (JP16); Adobiol (TN)
D01512 Befunolol hydrochloride (JAN); Bentos (TN)
D01543 Nylidrin hydrochloride (JAN); Buphenine hydrochloride; Arlidin (TN)
D01691 Nipradilol (JAN/INN); Hypadil (TN)
D01741 Celiprolol hydrochloride (JAN/USAN); Selectol (TN)
D01794 Bopindolol malonate (JAN); Sandonorm (TN)
D01795 Tilisolol hydrochloride (JAN); Selecal (TN)
D01806 Oxprenolol hydrochloride (JP16/USP); Okuspurecol (TN)
D01830 Arotinolol hydrochloride (JP16); Almarl (TN)
D01847 Landiolol hydrochloride (JAN); ONO 1101 hydrochloride; Onoact (TN)
D01952 L-Methylephedrine hydrochloride (JAN)
D01958 Indenolol hydrochloride (JP16)
D02066 Isoprenaline sulfate (JAN); Isoproterenol sulfate (USP); Luf-Iso (TN); Medihaler-Iso (TN)
D02081 Metipranolol hydrochloride; Optipranolol (TN)
D02109 dl-Methylephedrine hydrochloride (JP16); Methy-F (TN)
D02149 Epinephrine bitartrate (JAN/USP); Asmatane mist (TN); Medihaler-epi (TN)
D02150 l-Isoprenaline hydrochloride (JP16); Proternol-L (TN)
D02338 Acebutolol (USAN/INN)
D02342 Bisoprolol (JAN/USAN/INN)
D02349 Dipivefrin (USAN); Dipivefrine (INN)
D02358 Metoprolol (USAN/INN)
D02374 Metipranolol (USAN/INN)
D02389 Primidolol (USAN/INN)
D02537 Dronedarone (INN)
D02614 Denopamine (JAN/INN); Kalgut (TN)
D02702 Talibegron hydrochloride (USAN)
D02765 Adaprolol maleate (USAN)
D02834 Alprenoxime hydrochloride (USAN)
D02910 Amiodarone (USAN/INN)
D02976 Arbutamine hydrochloride (USAN); Genesa (TN)
D03170 Bucindolol hydrochloride (USAN)
D03177 Bunolol hydrochloride (USAN)
D03195 Butopamine (USAN/INN)
D03415 Carvedilol phosphate hydrate (JAN); Carvedilol phosphate (USAN); Coreg CR (TN)
D03449 Cetamolol hydrochloride (USAN)
D03490 Cicloprolol hydrochloride (USAN)
D03502 Cimaterol (USAN/INN)
D03729 Dexpropranolol hydrochloride (USAN)
D03759 Diacetolol hydrochloride (USAN)
D03879 Dobutamine (USP/INN)
D03880 Dobutamine lactobionate (USAN)
D03881 Dobutamine tartrate (USP)
D03914 Dronedarone hydrochloride (USAN); Multaq (TN)
D04018 Ephedrine sulfate (USP); Isofedrol (TN)
D04190 Flestolol sulfate (USAN)
D04708 Levdobutamine lactobionate (USAN)
D04710 Levobetaxolol hydrochloride (USAN); Betaxon (TN)
D04888 Medroxalol (USAN/INN)
D04889 Medroxalol hydrochloride (USAN)
D05011 Metoprolol fumarate (USP); Lopressor (TN)
D05127 Nebivolol (USAN/INN)
D05206 Norepinephrine bitartrate (USP); Levophed (TN)
D05345 Pamatolol sulfate (USAN)
D05587 Practolol (USAN)
D05606 Prenalterol hydrochloride (USAN)
D05648 Pseudoephedrine polistirex (USAN); Pseudo-12 (TN)
D05649 Pseudoephedrine sulfate (USP); Afrinol (TN)
D06328 Xamoterol (USAN)
D06329 Xamoterol fumarate (USAN)
D06622 Nebivolol hydrochloride (USAN); Bystolic (TN)
D06646 Epanolol (USAN/INN)
D07156 Alprenolol (INN)
D07181 Mepindolol (INN)
D07182 Tertatolol (INN)
D07183 Cloranolol (INN)
D07184 Talinolol (INN)
D07451 Amosulalol (INN)
D07465 Arotinolol (INN)
D07526 Betaxolol (INN); Betaxolol (TN)
D07537 Bopindolol (INN); Sandonorm (TN)
D07551 Buphenine (INN)
D07590 Bupranolol (INN)
D07624 Carteolol (INN)
D07660 Celiprolol (INN); Celiprolol PCH (TN)
D07916 Esmolol (INN)
D08074 Penbutolol (INN)
D08078 Indenolol (INN)
D08090 Isoprenaline (INN)
D08106 Labetalol (INN)
D08115 Levobunolol (INN)
D08206 Methylephedrine (BAN)
D08284 Norepinephrine hydrochoride; (-)-Noradrenaline hydrochloride; Arterenol (TN)
D08318 Oxprenolol (INN); Oxprenolol (TN)
D08435 Propafenone (INN); Propafenon hexal (TN)
D08443 Propranolol (INN); Propranolol (TN)
D08449 Pseudoephedrine (INN); Neodurasina (TN); Acunaso (TN)
D08525 Sotalol (INN); Darob mite (TN)
D08572 Tertatolol hydrochloride; Artex (TN)
D08598 Tilisolol (INN)
D08600 Timolol (INN); Timolol (TN); Betimol (TN)
D09794 Norepinephrine hydrochloride (JAN); (+/-)-Noradrenaline hydrochloride
D09842 dl-Methylephedrine saccharinate (JAN)
D09843 Beradilol monoethyl maleate (JAN); TZC-5665
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADRB1_HUMAN

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