| UniProt ID | AGRB1_HUMAN | |
|---|---|---|
| UniProt AC | O14514 | |
| Protein Name | Adhesion G protein-coupled receptor B1 {ECO:0000312|HGNC:HGNC:943} | |
| Gene Name | ADGRB1 {ECO:0000312|HGNC:HGNC:943} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1584 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cell projection, phagocytic cup . Cell junction, focal adhesion . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Vasculostatin-120: Secreted . V |
|
| Protein Description | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. [PubMed: 24509909 Also mediates the binding and engulfment of Gram-negative bacteria] | |
| Protein Sequence | MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGKFFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPSAPLAFLQASKQFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILSNLLAEENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTTVLNSKVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKPEKQQTPNKRPWESLRKAHGTPTWVKKELEPLQPSPLELRSVEWERSGATIPLVGQDIIDLQTEV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 64 | N-linked_Glycosylation | AAAVFPANASRCSWT EEEEEECCHHHCEEE | UniProtKB CARBOHYD | ||
| 66 | Phosphorylation | AVFPANASRCSWTLR EEEECCHHHCEEEEC | - | ||
| 81 | Phosphorylation | NPDPRRYTLYMKVAK CCCCCCEEEEEEEEC | 24719451 | ||
| 83 | Phosphorylation | DPRRYTLYMKVAKAP CCCCEEEEEEEECCC | 24719451 | ||
| 114 | Phosphorylation | FLESTRTYLGVESFD HHHHHCCCCCCCCHH | 24719451 | ||
| 119 | Phosphorylation | RTYLGVESFDEVLRL CCCCCCCCHHHHHHH | 24719451 | ||
| 287 | Phosphorylation | GLQTRTRTCLPAPGV CCCCCCEEEECCCCC | - | ||
| 330 | Phosphorylation | RSQSLRSTDARRREE HHHHHHHCHHHHHHH | - | ||
| 401 | N-linked_Glycosylation | LREQRLCNNSAVCPV CHHHCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 537 | Phosphorylation | SWGSCSVTCGAGSQR EEECCEEEECCCCHH | - | ||
| 607 | N-linked_Glycosylation | AAVRCPRNATGLILR EEEECCCCCCEEEEE | UniProtKB CARBOHYD | ||
| 609 | Phosphorylation | VRCPRNATGLILRRC EECCCCCCEEEEEEC | 23186163 | ||
| 692 | N-linked_Glycosylation | STIDVLRNMTEIFRR HHHHHHHHHHHHHHH | UniProtKB CARBOHYD | ||
| 844 | N-linked_Glycosylation | SFLALQRNTTVLNSK HHHHHCCCCEEEECE | UniProtKB CARBOHYD | ||
| 877 | N-linked_Glycosylation | IEFAHMYNGTTNQTC EEEEECCCCCCCCEE | UniProtKB CARBOHYD | ||
| 881 | N-linked_Glycosylation | HMYNGTTNQTCILWD ECCCCCCCCEEEEEE | UniProtKB CARBOHYD | ||
| 1210 | Phosphorylation | QEEGNGDSGGSFQNG CCCCCCCCCCCCCCC | 26471730 | ||
| 1213 | Phosphorylation | GNGDSGGSFQNGHAQ CCCCCCCCCCCCCEE | 26471730 | ||
| 1223 | Phosphorylation | NGHAQLMTDFEKDVD CCCEEECCHHHHHHH | 26471730 | ||
| 1257 | Phosphorylation | TGTLKRPSLPEEEKL ECCCCCCCCCHHHHH | 25850435 | ||
| 1278 | Phosphorylation | GPPTNFNSLPANVSK CCCCCCCCCCCCCCE | 25850435 | ||
| 1306 | Phosphorylation | LPDFPNHSLTLKRDK CCCCCCCCEEECCCC | 25850435 | ||
| 1308 | Phosphorylation | DFPNHSLTLKRDKAP CCCCCCEEECCCCCC | 25850435 | ||
| 1317 | Phosphorylation | KRDKAPKSSFVGDGD CCCCCCCCCCCCCHH | 25850435 | ||
| 1318 | Phosphorylation | RDKAPKSSFVGDGDI CCCCCCCCCCCCHHH | 25850435 | ||
| 1343 | Phosphorylation | AQEKALDTSYVILPT HHHHHHCCCEEEEEC | 24719451 | ||
| 1350 | Phosphorylation | TSYVILPTATATLRP CCEEEEECCEECCCC | - | ||
| 1352 | Phosphorylation | YVILPTATATLRPKP EEEEECCEECCCCCC | 24719451 | ||
| 1354 | Phosphorylation | ILPTATATLRPKPKE EEECCEECCCCCCCC | 24719451 | ||
| 1382 | Phosphorylation | TRLIHLSTAPEASLP EEEEEEECCCCCCCC | 28348404 | ||
| 1387 | Phosphorylation | LSTAPEASLPARSPP EECCCCCCCCCCCCC | 24719451 | ||
| 1464 | Phosphorylation | TKNENVATLSVSSLE CCCCCCEEEEHHHHH | 27732954 | ||
| 1466 | Phosphorylation | NENVATLSVSSLERR CCCCEEEEHHHHHHH | 27732954 | ||
| 1468 | Phosphorylation | NVATLSVSSLERRKS CCEEEEHHHHHHHHH | 29255136 | ||
| 1469 | Phosphorylation | VATLSVSSLERRKSR CEEEEHHHHHHHHHH | 29255136 | ||
| 1475 | Phosphorylation | SSLERRKSRYAELDF HHHHHHHHHHHCCCH | 28348404 | ||
| 1477 | Phosphorylation | LERRKSRYAELDFEK HHHHHHHHHCCCHHH | 27642862 | ||
| 1528 | Acetylation | EKQQTPNKRPWESLR HHCCCCCCCCHHHHH | 7409377 | ||
| 1554 | Phosphorylation | ELEPLQPSPLELRSV CCCCCCCCCCEECEE | 29255136 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGRB1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGRB1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGRB1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MAGI1_HUMAN | MAGI1 | physical | 9647739 | |
| BAIP3_HUMAN | BAIAP3 | physical | 9790924 | |
| AGRB1_HUMAN | BAI1 | physical | 23782696 | |
| MAGI1_HUMAN | MAGI1 | physical | 23782696 | |
| MAGI2_HUMAN | MAGI2 | physical | 23782696 | |
| MAGI3_HUMAN | MAGI3 | physical | 23782696 | |
| DLG4_HUMAN | DLG4 | physical | 23782696 | |
| INADL_HUMAN | INADL | physical | 23782696 | |
| DLG1_HUMAN | DLG1 | physical | 23782696 | |
| LIN7A_HUMAN | LIN7A | physical | 23782696 | |
| LRRC7_HUMAN | LRRC7 | physical | 23782696 | |
| SNTA1_HUMAN | SNTA1 | physical | 23782696 | |
| SNTB1_HUMAN | SNTB1 | physical | 23782696 | |
| SNTB2_HUMAN | SNTB2 | physical | 23782696 | |
| SNTG2_HUMAN | SNTG2 | physical | 23782696 | |
| PDZD2_HUMAN | PDZD2 | physical | 23782696 | |
| BAIP2_HUMAN | BAIAP2 | physical | 10343108 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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