LRRC7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRC7_HUMAN
• UniProt AC: Q96NW7
• Protein Name: Leucine-rich repeat-containing protein 7
• Gene Name: LRRC7
• Organism: Homo sapiens (Human).
• Sequence Length: 1537
• Subcellular Localization: Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
• Protein Description: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression..
• Protein Sequence: MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	ERTLEELYLDANQIE HHHHHHHHCCHHHHH	13.05	22817900
175 (in isoform 3)	Phosphorylation	-	55.44	20068231
230	Ubiquitination	PGSIGKLKMLVYLDM CCCHHHHEEEEEEEC	33.40	-
234	Phosphorylation	GKLKMLVYLDMSKNR HHHEEEEEEECCCCC	7.94	-
343	Phosphorylation	ELPREIGSCKNVTVM CCCHHHCCCCCEEEE	27.81	-
348	Phosphorylation	IGSCKNVTVMSLRSN HCCCCCEEEEECCCC	21.64	-
351	Phosphorylation	CKNVTVMSLRSNKLE CCCEEEEECCCCCCC	19.12	-
354	Phosphorylation	VTVMSLRSNKLEFLP EEEEECCCCCCCCCH	43.54	29083192
381	Ubiquitination	NLSDNRLKNLPFSFT ECCCCCHHCCCCCHH	53.88	-
386	Phosphorylation	RLKNLPFSFTKLKEL CHHCCCCCHHHHHHH	30.02	24719451
411	Phosphorylation	KALIPLQTEAHPETK CCEEECCCCCCHHHH	42.70	20068231
417	Phosphorylation	QTEAHPETKQRVLTN CCCCCHHHHHHHHHH	36.61	20068231
439	Phosphorylation	RGDEDFQSDSDSFNP CCCCCCCCCCCCCCH	38.79	24076635
441	Phosphorylation	DEDFQSDSDSFNPTL CCCCCCCCCCCCHHH	40.16	-
443	Phosphorylation	DFQSDSDSFNPTLWE CCCCCCCCCCHHHHH	30.76	24076635
568	Phosphorylation	VEINLKRYPTPYPED EEEEEEECCCCCHHH	15.18	28634298
570	Phosphorylation	INLKRYPTPYPEDLK EEEEECCCCCHHHHH	26.90	28857561
572	Phosphorylation	LKRYPTPYPEDLKNM EEECCCCCHHHHHHH	23.02	-
599	Phosphorylation	HGVRVENSNPTANTE CCCCCCCCCCCCCCC	30.58	29888752
602	Phosphorylation	RVENSNPTANTEQTV CCCCCCCCCCCCHHH	36.47	29888752
605	Phosphorylation	NSNPTANTEQTVKEK CCCCCCCCCHHHHHH	27.32	29888752
608	Phosphorylation	PTANTEQTVKEKYEH CCCCCCHHHHHHHCC	27.58	29888752
612	Acetylation	TEQTVKEKYEHKWPV CCHHHHHHHCCCCCC	50.66	7935107
613	Phosphorylation	EQTVKEKYEHKWPVA CHHHHHHHCCCCCCC	25.10	29888752
667	Phosphorylation	GKDKKESTDESEVDK CCCCCCCCCHHHCCH	44.89	30576142
681	Phosphorylation	KTHCLNNSVSSGTYS HHHHCCCCCCCCCCC	23.46	30576142
684	Phosphorylation	CLNNSVSSGTYSDYS HCCCCCCCCCCCCCC	32.76	30576142
687	Phosphorylation	NSVSSGTYSDYSPSQ CCCCCCCCCCCCHHH	11.76	30576142
690	Phosphorylation	SSGTYSDYSPSQASS CCCCCCCCCHHHCCC	19.28	30576142
697	Phosphorylation	YSPSQASSGSSNTRV CCHHHCCCCCCCCCE	45.79	30576142
708	Phosphorylation	NTRVKVGSLQTTAKD CCCEEECCEECHHHH	21.94	20068231
711	Phosphorylation	VKVGSLQTTAKDAVH EEECCEECHHHHHHH	33.73	20068231
712	Phosphorylation	KVGSLQTTAKDAVHN EECCEECHHHHHHHH	20.81	20068231
736	Phosphorylation	SFPQPLDSKPLLSQR CCCCCCCCCCCCCCC	43.80	24719451
741	Phosphorylation	LDSKPLLSQREAVPP CCCCCCCCCCCCCCC	34.57	24719451
799	Phosphorylation	NPLLSSKSRSTSSHG CCCCCCCCCCCCCCC	33.15	23312004
801	Phosphorylation	LLSSKSRSTSSHGRR CCCCCCCCCCCCCCC	39.47	23312004
802	Phosphorylation	LSSKSRSTSSHGRRP CCCCCCCCCCCCCCC	32.89	23312004
803	Phosphorylation	SSKSRSTSSHGRRPL CCCCCCCCCCCCCCC	22.91	23312004
804	Phosphorylation	SKSRSTSSHGRRPLI CCCCCCCCCCCCCCC	30.01	23312004
831	Phosphorylation	EQSTHRHTPETEVPP ECCCCCCCCCCCCCC	23.83	-
850	Phosphorylation	QNWTRTPSPFEDRTA CCCCCCCCCCCCCCC	41.42	27732954
856	Phosphorylation	PSPFEDRTAFPSKLE CCCCCCCCCCCCCCC	45.00	-
864	Phosphorylation	AFPSKLETTPTTSPL CCCCCCCCCCCCCCC	48.81	27732954
865	Phosphorylation	FPSKLETTPTTSPLP CCCCCCCCCCCCCCC	14.84	20363803
867	Phosphorylation	SKLETTPTTSPLPER CCCCCCCCCCCCCCH	37.50	20363803
868	Phosphorylation	KLETTPTTSPLPERK CCCCCCCCCCCCCHH	29.56	27732954
869	Phosphorylation	LETTPTTSPLPERKE CCCCCCCCCCCCHHH	27.24	20363803
910	O-linked_Glycosylation	RSLSNVFSQIHCRPE CCHHHHHHHHCCCCC	24.76	30379171
919	O-linked_Glycosylation	IHCRPESSKGVISIS HCCCCCCCCCEEEEE	31.59	30379171
924	Phosphorylation	ESSKGVISISKSTER CCCCCEEEEECCCCC	20.57	24719451
947	Phosphorylation	KSNKFKKSQSIDEID HCCCCCCCCCCCEEE	29.74	27732954
949	Phosphorylation	NKFKKSQSIDEIDIG CCCCCCCCCCEEECC	38.81	27732954
997	Phosphorylation	GMSSMSRSQSVPMLD CCCCCCCCCCCCCCC	21.35	27732954
999	Phosphorylation	SSMSRSQSVPMLDDE CCCCCCCCCCCCCHH	29.45	27732954
1012	Phosphorylation	DEMLTYGSSKGPQQQ HHHHHCCCCCCHHHH	20.61	-
1013	Phosphorylation	EMLTYGSSKGPQQQK HHHHCCCCCCHHHHH	36.95	-
1072	Phosphorylation	NIAKDLISPRAYRGY HHHHHHCCCCHHCCC	18.68	24719451
1118	Phosphorylation	GFLRRADSLVSATEM HHHHHHHHHHHHHHH	29.68	-
1148	Phosphorylation	DRYGRPPYRGGLDRQ CCCCCCCCCCCCCCC	25.27	23532336
1149	Methylation	RYGRPPYRGGLDRQS CCCCCCCCCCCCCCC	38.18	-
1156	Phosphorylation	RGGLDRQSSVTVTES CCCCCCCCCEEEEHH	27.89	-
1159	Phosphorylation	LDRQSSVTVTESQFL CCCCCCEEEEHHHHH	24.53	25690035
1161	Phosphorylation	RQSSVTVTESQFLKR CCCCEEEEHHHHHHH	22.13	25690035
1161	O-linked_Glycosylation	RQSSVTVTESQFLKR CCCCEEEEHHHHHHH	22.13	30379171
1163	Phosphorylation	SSVTVTESQFLKRNG CCEEEEHHHHHHHCC	19.50	-
1167	Methylation	VTESQFLKRNGRYED EEHHHHHHHCCCCCC	45.14	115972623
1179	Phosphorylation	YEDEHPSYQEVKAQA CCCCCCCHHHHHHHC	17.10	22817900
1204	Phosphorylation	RRPLSARSYSTESYG CCCCCCCCCCCCCCC	24.13	24043423
1205	Phosphorylation	RPLSARSYSTESYGA CCCCCCCCCCCCCCC	17.66	22817900
1206	Phosphorylation	PLSARSYSTESYGAS CCCCCCCCCCCCCCC	27.26	24043423
1207	Phosphorylation	LSARSYSTESYGASQ CCCCCCCCCCCCCCC	22.25	22817900
1209	Phosphorylation	ARSYSTESYGASQTR CCCCCCCCCCCCCCC	29.02	22817900
1210	Phosphorylation	RSYSTESYGASQTRP CCCCCCCCCCCCCCC	15.52	22817900
1213	Phosphorylation	STESYGASQTRPVSA CCCCCCCCCCCCCCC	27.93	24043423
1215	Phosphorylation	ESYGASQTRPVSARP CCCCCCCCCCCCCCH	34.15	22817900
1233	Phosphorylation	ALLEKIPSDYNLGNY HHHHHCCCCCCCCCC	57.08	-
1335	Phosphorylation	LPLQKTPSQQSNILD CCCCCCHHHHCCCCC	46.19	-
1368	Phosphorylation	RRDVPPDTITKKAGS CCCCCCCHHHHHCHH	36.00	-
1370	Phosphorylation	DVPPDTITKKAGSHI CCCCCHHHHHCHHHH	28.69	-
1383	Phosphorylation	HIQTLMGSQSLQHRS HHHHHHCCHHHHCCC	11.57	-
1439	Phosphorylation	IQTKGQRSMDGYPEQ EEECCCCCCCCCCCC	17.21	11160423
1491	Phosphorylation	VQPDGPASNLLQPGD ECCCCCHHHCCCCCC	31.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRC7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRC7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRC7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNKR2_HUMAN	CNKSR2	physical	12390249
DLG4_HUMAN	DLG4	physical	12390249
CTND2_HUMAN	CTNND2	physical	11729199
CADH2_HUMAN	CDH2	physical	11729199
HOMEZ_HUMAN	HOMEZ	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.