CTND2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTND2_HUMAN
• UniProt AC: Q9UQB3
• Protein Name: Catenin delta-2
• Gene Name: CTNND2
• Organism: Homo sapiens (Human).
• Sequence Length: 1225
• Subcellular Localization: Nucleus . Cell junction, adherens junction . Cell projection, dendrite . Perikaryon .
• Protein Description: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. [PubMed: 25807484 Involved in the regulation of Wnt signaling]
• Protein Sequence: MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSETETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQFQWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNSKPEGSFQYPASYHSNQTLALGETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEPAPPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLAAPQGGSPTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSPPTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLAAGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHTGTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQYCPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVLTNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEANGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLHEVITKNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDGWSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKTDYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYRNSYGAPAEDIKHNQVSAQPVPQEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAARPYSELNYETSHYPASPDSWV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	PSSASEKTSSLSPGL CCCCCCCCCCCCCCC	21.35	24076635
30	Phosphorylation	SASEKTSSLSPGLNT CCCCCCCCCCCCCCC	37.79	24076635
32	Phosphorylation	SEKTSSLSPGLNTSN CCCCCCCCCCCCCCC	20.90	15345747
37	Phosphorylation	SLSPGLNTSNGDGSE CCCCCCCCCCCCCCC	28.72	24076635
38	Phosphorylation	LSPGLNTSNGDGSET CCCCCCCCCCCCCCH	37.43	28348404
43	Phosphorylation	NTSNGDGSETETTSA CCCCCCCCCHHHHHH	46.19	25332170
45	Phosphorylation	SNGDGSETETTSAIL CCCCCCCHHHHHHHH	40.09	28348404
78	Phosphorylation	AERQIVASQLERCKL HHHHHHHHHHHHHCC	25.14	23403867
149	Phosphorylation	YSTGERPSLLSQSAL CCCCCCCCHHCHHHH	48.43	22210691
160	Phosphorylation	QSALQLNSKPEGSFQ HHHHHCCCCCCCCCC	59.17	22210691
183	Phosphorylation	QTLALGETTPSQLPA CEEEECCCCHHHCCC	42.06	22210691
201	Phosphorylation	QARATGQSFSQGTTS CCCCCCCCCCCCCCC	28.36	25307156
207	Phosphorylation	QSFSQGTTSRAGHLA CCCCCCCCCCCCCCC	24.04	24114839
209	Methylation	FSQGTTSRAGHLAGP CCCCCCCCCCCCCCC	42.36	-
253	Phosphorylation	AAAAAALYYSSSTLP HHHHHHHHHCCCCCC	9.14	27642862
254	Phosphorylation	AAAAALYYSSSTLPA HHHHHHHHCCCCCCC	11.70	27642862
256	Phosphorylation	AAALYYSSSTLPAPP HHHHHHCCCCCCCCC	15.95	27642862
264	Methylation	STLPAPPRGGSPLAA CCCCCCCCCCCCCCC	62.13	-
267	Phosphorylation	PAPPRGGSPLAAPQG CCCCCCCCCCCCCCC	21.40	22617229
276	Phosphorylation	LAAPQGGSPTKLQRG CCCCCCCCCCCCCCC	35.90	22617229
278	Phosphorylation	APQGGSPTKLQRGGS CCCCCCCCCCCCCCC	46.19	25849741
282	Methylation	GSPTKLQRGGSAPEG CCCCCCCCCCCCCCC	62.97	-
285	O-linked_Glycosylation	TKLQRGGSAPEGATY CCCCCCCCCCCCCCC	43.40	OGP
285	Phosphorylation	TKLQRGGSAPEGATY CCCCCCCCCCCCCCC	43.40	24670416
291	Phosphorylation	GSAPEGATYAAPRGS CCCCCCCCCCCCCCC	25.26	26330541
292	Phosphorylation	SAPEGATYAAPRGSS CCCCCCCCCCCCCCC	10.55	25884760
296	Methylation	GATYAAPRGSSPKQS CCCCCCCCCCCCCCC	53.55	-
298	Phosphorylation	TYAAPRGSSPKQSPS CCCCCCCCCCCCCHH	44.75	30576142
299	Phosphorylation	YAAPRGSSPKQSPSR CCCCCCCCCCCCHHH	38.65	25849741
303	Phosphorylation	RGSSPKQSPSRLAKS CCCCCCCCHHHHHHH	30.85	20363803
305	Phosphorylation	SSPKQSPSRLAKSYS CCCCCCHHHHHHHCC	45.21	20363803
310	O-linked_Glycosylation	SPSRLAKSYSTSSPI CHHHHHHHCCCCCCE	20.78	30379171
313	Phosphorylation	RLAKSYSTSSPINIV HHHHHCCCCCCEEEE	25.62	24076635
314	Phosphorylation	LAKSYSTSSPINIVV HHHHCCCCCCEEEEE	28.33	24076635
315	O-linked_Glycosylation	AKSYSTSSPINIVVS HHHCCCCCCEEEEEE	29.86	30379171
315	Phosphorylation	AKSYSTSSPINIVVS HHHCCCCCCEEEEEE	29.86	24076635
322	O-linked_Glycosylation	SPINIVVSSAGLSPI CCEEEEEECCCCCCC	11.99	30379171
323	O-linked_Glycosylation	PINIVVSSAGLSPIR CEEEEEECCCCCCCE	18.10	30379171
323	Phosphorylation	PINIVVSSAGLSPIR CEEEEEECCCCCCCE	18.10	28348404
327	O-linked_Glycosylation	VVSSAGLSPIRVTSP EEECCCCCCCEECCC	19.84	30379171
327	Phosphorylation	VVSSAGLSPIRVTSP EEECCCCCCCEECCC	19.84	24076635
332	Phosphorylation	GLSPIRVTSPPTVQS CCCCCEECCCCCCCC	26.18	22210691
333	Phosphorylation	LSPIRVTSPPTVQST CCCCEECCCCCCCCC	26.48	28348404
336	Phosphorylation	IRVTSPPTVQSTISS CEECCCCCCCCCCCC	34.26	22210691
339	Phosphorylation	TSPPTVQSTISSSPI CCCCCCCCCCCCCCH	24.30	28348404
340	Phosphorylation	SPPTVQSTISSSPIH CCCCCCCCCCCCCHH	14.05	28348404
342	Phosphorylation	PTVQSTISSSPIHQL CCCCCCCCCCCHHHH	25.50	24076635
343	Phosphorylation	TVQSTISSSPIHQLS CCCCCCCCCCHHHHH	35.96	28348404
344	Phosphorylation	VQSTISSSPIHQLSS CCCCCCCCCHHHHHC	22.53	28348404
356	Phosphorylation	LSSTIGTYATLSPTK HHCCCCCEEECCCHH	7.74	27642862
358	Phosphorylation	STIGTYATLSPTKRL CCCCCEEECCCHHHH	19.84	24076635
360	Phosphorylation	IGTYATLSPTKRLVH CCCEEECCCHHHHHH	26.60	24719451
369	Phosphorylation	TKRLVHASEQYSKHS HHHHHHCHHHHHHHC	15.45	26330541
372	Phosphorylation	LVHASEQYSKHSQEL HHHCHHHHHHHCCCH	18.68	25884760
373	Phosphorylation	VHASEQYSKHSQELY HHCHHHHHHHCCCHH	24.48	26330541
380	Phosphorylation	SKHSQELYATATLQR HHHCCCHHHEEEECC	10.93	24927040
384	Phosphorylation	QELYATATLQRPGSL CCHHHEEEECCCCCC	21.04	25849741
390	Phosphorylation	ATLQRPGSLAAGSRA EEECCCCCCCCCCCC	19.95	24719451
395	Phosphorylation	PGSLAAGSRASYSSQ CCCCCCCCCCCCHHC	21.68	27251275
398	Phosphorylation	LAAGSRASYSSQHGH CCCCCCCCCHHCCCC	25.16	25849741
399	Phosphorylation	AAGSRASYSSQHGHL CCCCCCCCHHCCCCC	16.03	25884760
400	Phosphorylation	AGSRASYSSQHGHLG CCCCCCCHHCCCCCC	22.49	28348404
401	Phosphorylation	GSRASYSSQHGHLGP CCCCCCHHCCCCCCH	20.26	28348404
415	Phosphorylation	PELRALQSPEHHIDP HHHHHCCCCCCCCCC	32.86	25849741
424	Phosphorylation	EHHIDPIYEDRVYQK CCCCCCCCCCCCCCC	19.71	25884760
429	Phosphorylation	PIYEDRVYQKPPMRS CCCCCCCCCCCCCCC	16.24	26330541
436	Phosphorylation	YQKPPMRSLSQSQGD CCCCCCCCCCHHCCC	26.56	22912867
438	Phosphorylation	KPPMRSLSQSQGDPL CCCCCCCCHHCCCCC	29.09	26657352
440	Phosphorylation	PMRSLSQSQGDPLPP CCCCCCHHCCCCCCC	32.52	24076635
455	Phosphorylation	AHTGTYRTSTAPSSP CCCCCEECCCCCCCC	21.73	24076635
456	O-linked_Glycosylation	HTGTYRTSTAPSSPG CCCCEECCCCCCCCC	17.36	30379171
456	Phosphorylation	HTGTYRTSTAPSSPG CCCCEECCCCCCCCC	17.36	28102081
457	Phosphorylation	TGTYRTSTAPSSPGV CCCEECCCCCCCCCC	41.81	22617229
460	Phosphorylation	YRTSTAPSSPGVDSV EECCCCCCCCCCCCC	46.85	22617229
461	Phosphorylation	RTSTAPSSPGVDSVP ECCCCCCCCCCCCCC	25.31	25849741
466	Phosphorylation	PSSPGVDSVPLQRTG CCCCCCCCCCCCCCC	24.19	24076635
472	Phosphorylation	DSVPLQRTGSQHGPQ CCCCCCCCCCCCCCC	28.37	25307156
474	Phosphorylation	VPLQRTGSQHGPQNA CCCCCCCCCCCCCHH	20.56	17525332
490	Phosphorylation	AATFQRASYAAGPAS HHHHHHHHHHCCCHH	19.93	25307156
497	Phosphorylation	SYAAGPASNYADPYR HHHCCCHHHCCCHHH	33.24	-
499	Phosphorylation	AAGPASNYADPYRQL HCCCHHHCCCHHHHH	15.19	24927040
503	Phosphorylation	ASNYADPYRQLQYCP HHHCCCHHHHHCCCC	16.13	24927040
508	Phosphorylation	DPYRQLQYCPSVESP CHHHHHCCCCCCCCC	18.21	-
511	Phosphorylation	RQLQYCPSVESPYSK HHHCCCCCCCCCCCC	34.65	24719451
514	Phosphorylation	QYCPSVESPYSKSGP CCCCCCCCCCCCCCC	27.29	24076635
516	Phosphorylation	CPSVESPYSKSGPAL CCCCCCCCCCCCCCC	37.70	24927040
517	O-linked_Glycosylation	PSVESPYSKSGPALP CCCCCCCCCCCCCCC	24.59	30379171
517	Phosphorylation	PSVESPYSKSGPALP CCCCCCCCCCCCCCC	24.59	-
532	Phosphorylation	PEGTLARSPSIDSIQ CCCCCCCCCCHHHHC	19.86	30266825
534	Phosphorylation	GTLARSPSIDSIQKD CCCCCCCCHHHHCCC	40.03	30266825
537	Phosphorylation	ARSPSIDSIQKDPRE CCCCCHHHHCCCHHH	25.83	30266825
540	Ubiquitination	PSIDSIQKDPREFGW CCHHHHCCCHHHHCC	68.94	21890473
540 (in isoform 1)	Ubiquitination	-	68.94	21890473
540 (in isoform 2)	Ubiquitination	-	68.94	21890473
818 (in isoform 2)	Phosphorylation	-	48.12	23663014
823 (in isoform 2)	Phosphorylation	-	35.95	23663014
825 (in isoform 2)	Phosphorylation	-	7.09	23663014
873 (in isoform 2)	Ubiquitination	-	1.92	21890473
926	Ubiquitination	MALDVRNKELIGKYA HHHHCCCHHHHHHHH	43.25	-
931	Ubiquitination	RNKELIGKYAMRDLV CCHHHHHHHHHHHHH	23.89	21890473
931	Ubiquitination	RNKELIGKYAMRDLV CCHHHHHHHHHHHHH	23.89	-
931 (in isoform 1)	Ubiquitination	-	23.89	21890473
932	Phosphorylation	NKELIGKYAMRDLVH CHHHHHHHHHHHHHH	10.62	-
947	Phosphorylation	RLPGGNNSNNTASKA HCCCCCCCCCHHHHH	35.14	24275569
950	Phosphorylation	GGNNSNNTASKAMSD CCCCCCCHHHHHCCC	36.24	24275569
952	Phosphorylation	NNSNNTASKAMSDDT CCCCCHHHHHCCCHH	20.93	24275569
956	Phosphorylation	NTASKAMSDDTVTAV CHHHHHCCCHHHHHH	36.88	24275569
966	Phosphorylation	TVTAVCCTLHEVITK HHHHHHHHHHHHHHH	26.48	24275569
1002	Phosphorylation	KSKGDKHSPKVVKAA CCCCCCCCHHHHHHH	31.96	-
1034	Phosphorylation	KKDGWSQYHFVASSS HHCCCCCEEEEEECC	7.54	24076635
1040	Phosphorylation	QYHFVASSSTIERDR CEEEEEECCCHHHHC	23.05	24076635
1042	Phosphorylation	HFVASSSTIERDRQR EEEEECCCHHHHCCC	28.89	-
1051	Phosphorylation	ERDRQRPYSSSRTPS HHHCCCCCCCCCCCC	24.31	22985185
1056	Phosphorylation	RPYSSSRTPSISPVR CCCCCCCCCCCCCCE	24.28	28102081
1058	Phosphorylation	YSSSRTPSISPVRVS CCCCCCCCCCCCEEC	34.78	23909892
1060	Phosphorylation	SSRTPSISPVRVSPN CCCCCCCCCCEECCC	22.98	20886841
1065	Phosphorylation	SISPVRVSPNNRSAS CCCCCEECCCCCCCC	16.02	25849741
1070	Phosphorylation	RVSPNNRSASAPASP EECCCCCCCCCCCCH	28.79	22468782
1072	Phosphorylation	SPNNRSASAPASPRE CCCCCCCCCCCCHHH	35.71	27251275
1076	Phosphorylation	RSASAPASPREMISL CCCCCCCCHHHHCCC	24.35	25849741
1088	Phosphorylation	ISLKERKTDYECTGS CCCCCCCCCCCCCCC	50.46	26330541
1090	Phosphorylation	LKERKTDYECTGSNA CCCCCCCCCCCCCCC	20.38	26330541
1093	Phosphorylation	RKTDYECTGSNATYH CCCCCCCCCCCCEEC	31.53	26330541
1099	Phosphorylation	CTGSNATYHGAKGEH CCCCCCEECCCCCCC	8.88	25884760
1122	Phosphorylation	AQNTGISTLYRNSYG HHHHCCHHHHHCCCC	26.36	-
1124	Phosphorylation	NTGISTLYRNSYGAP HHCCHHHHHCCCCCC	14.08	27642862
1127	Phosphorylation	ISTLYRNSYGAPAED CHHHHHCCCCCCHHH	18.88	24076635
1150	Phosphorylation	QPVPQEPSRKDYETY CCCCCCCCCCCCCCC	51.73	26330541
1154	Phosphorylation	QEPSRKDYETYQPFQ CCCCCCCCCCCCCCC	17.13	24927040
1156	Phosphorylation	PSRKDYETYQPFQNS CCCCCCCCCCCCCCC	22.64	27642862
1157	Phosphorylation	SRKDYETYQPFQNST CCCCCCCCCCCCCCC	11.40	25884760
1163	Phosphorylation	TYQPFQNSTRNYDES CCCCCCCCCCCCCHH	20.26	24076635
1164	Phosphorylation	YQPFQNSTRNYDESF CCCCCCCCCCCCHHH	30.40	25307156
1167	Phosphorylation	FQNSTRNYDESFFED CCCCCCCCCHHHHCC	20.14	27642862
1183	Phosphorylation	VHHRPPASEYTMHLG CCCCCCHHHEEEEEE	36.59	27642862
1186	Phosphorylation	RPPASEYTMHLGLKS CCCHHHEEEEEECCC	8.28	27642862
1193	Phosphorylation	TMHLGLKSTGNYVDF EEEEECCCCCCCCCC	46.73	19060867
1194	Phosphorylation	MHLGLKSTGNYVDFY EEEECCCCCCCCCCC	28.05	24719451
1197	Phosphorylation	GLKSTGNYVDFYSAA ECCCCCCCCCCCCCC	11.62	25884760
1201	Phosphorylation	TGNYVDFYSAARPYS CCCCCCCCCCCCCCC	7.92	24719451
1207	Phosphorylation	FYSAARPYSELNYET CCCCCCCCCCCCCCC	14.82	-
1212	Phosphorylation	RPYSELNYETSHYPA CCCCCCCCCCCCCCC	32.96	27642862
1217	Phosphorylation	LNYETSHYPASPDSW CCCCCCCCCCCCCCC	10.56	-
1220	Phosphorylation	ETSHYPASPDSWV-- CCCCCCCCCCCCC--	25.41	24076635

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTND2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTND2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTND2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CTND2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474, AND MASSSPECTROMETRY.
PubMed: 17525332