BAIP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAIP3_HUMAN
• UniProt AC: O94812
• Protein Name: BAI1-associated protein 3 {ECO:0000303|PubMed:9790924}
• Gene Name: BAIAP3 {ECO:0000303|PubMed:28626000, ECO:0000312|HGNC:HGNC:948}
• Organism: Homo sapiens (Human).
• Sequence Length: 1187
• Subcellular Localization: Cytoplasm, cytosol . Recycling endosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane prote
• Protein Description: Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin. [PubMed: 28626000 Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity]
• Protein Sequence: MRPRGAAFAAGPPGDLHLGTAIGFAGAIWRSRSPAMSTLLDIKSSVLRQVQVCPSFRRRTEQDPGSASADPQEPATGAWKPGDGVEFFAHMRLMLKKGEGRQGLPCLEVPLRSGSPAPPEPVDPSLGLRALAPEEVEMLYEEALYTVLYRAGTMGPDQVDDEEALLSYLQQVFGTSLEEHTEAIERVRKAKAPTYALKVSVMRAKNLLAKDPNGFSDPYCMLGILPASDATREPRAQKEQRFGFRKGSKRGGPLPAKCIQVTEVKSSTLNPVWKEHFLFEIEDVSTDQLHLDIWDHDDDVSLVEACRKLNEVIGLKGMGRYFKQIVKSARANGTAGPTEDHTDDFLGCLNIPVREVPVAGVDRWFKLEPRSSASRVQGHCHLVLKLITTQRDTAMSQRGRSGFLSHLLLLSHLLRLEHSAEEPNSSSWRGELSTPAATILCLHGAQSNLSPLQLAVLHWQVSSRHHQTCTLDYSYLLGLLEDMQAHWEEAPSLPQEQEESLADSLSAFSEFGLQLLRQLRDYFPATNSTAVHRLELLLKCLGKLQLFQPSFEICPFESELNMDIAAALKRGNREWYDRILNDKSPREQPGPQRLPGLVVLADAVYDDLQFCYSVYASLFHSILNVDVFTLTFRQLERLVAEEAWVLTEELSPKMTLEVASGLFELYLTLADLQRFWDSIPGRDSRSLALAGIHAPFLPAVKLWFQVLRDQAKWRLQGAVDMDTLEPVDASSRHSSSAATAGLCLSHIQELWVRLAWPDPAQAQGLGTQLGQDVCEATLFYTELLRKKVDTQPGAAGEAVSEALCVVLNNVELVRKAAGQALKGLAWPEGATGPEGVLPRPLLSCTQALDDDLQREAHTVTAHLTSKMVGDIRKYVQHISLSPDSIQNDEAVAPLMKYLDEKLALLNASLVKGNLSRVLEALWELLLQAILQALGANRDVSADFYSRFHFTLEALVSFFHAEGQGLPLESLRDGSYKRLKEELRLHKCSTRECIEQFYLDKLKQRTLEQNRFGRLSVRCHYEAAEQRLAVEVLHAADLLPLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKTRTLHPVYDELFYFSVPAEACRRRAACVLFTVMDHDWLSTNDFAGEAALGLGGVTGVARPQVGGGARAGQPVTLHLCRPRAQVRSALRRLEGRTSKEAQEFVKKLKELEKCMEADP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MRPRGAAFAAGPPGD CCCCCCCCCCCCCCC	4.79	30230243
9 (in isoform 7)	Phosphorylation	-	13.54	27762562
9 (in isoform 6)	Phosphorylation	-	13.54	27762562
9 (in isoform 5)	Phosphorylation	-	13.54	27762562
9 (in isoform 3)	Phosphorylation	-	13.54	27762562
9 (in isoform 2)	Phosphorylation	-	13.54	27762562
10 (in isoform 7)	Phosphorylation	-	25.27	27762562
10 (in isoform 6)	Phosphorylation	-	25.27	27762562
10 (in isoform 5)	Phosphorylation	-	25.27	27762562
10 (in isoform 3)	Phosphorylation	-	25.27	27762562
10 (in isoform 2)	Phosphorylation	-	25.27	27762562
43	Ubiquitination	MSTLLDIKSSVLRQV HHHHHHHHHHHHHHC	36.02	30230243
113	Phosphorylation	CLEVPLRSGSPAPPE EEEEECCCCCCCCCC	51.83	26657352
115	Phosphorylation	EVPLRSGSPAPPEPV EEECCCCCCCCCCCC	21.09	27050516
248	Phosphorylation	RFGFRKGSKRGGPLP HHCCCCCCCCCCCCC	23.39	-
249	Acetylation	FGFRKGSKRGGPLPA HCCCCCCCCCCCCCC	64.83	18528449
262	Phosphorylation	PAKCIQVTEVKSSTL CCCEEEEEEEECCCC	20.77	-
388	Phosphorylation	HLVLKLITTQRDTAM HHHEEHHHHCHHHHH	27.58	23898821
396	Phosphorylation	TQRDTAMSQRGRSGF HCHHHHHHHHCHHHH	17.79	23898821
584	Phosphorylation	DRILNDKSPREQPGP HHHHCCCCCCCCCCC	31.86	25332170
908	Phosphorylation	KLALLNASLVKGNLS HHHHHHHHHHCCCHH	32.40	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BAIP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAIP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAIP3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BAIP3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.