TSP50_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSP50_HUMAN
• UniProt AC: Q9UI38
• Protein Name: Probable threonine protease PRSS50
• Gene Name: PRSS50
• Organism: Homo sapiens (Human).
• Sequence Length: 385
• Subcellular Localization: Endoplasmic reticulum . May also localize to cytoplasmic membranes.
• Protein Description: May be involved in proteolysis through its threonine endopeptidase activity..
• Protein Sequence: MGRWCQTVARGQRPRTSAPSRAGALLLLLLLLRSAGCWGAGEAPGALSTADPADQSVQCVPKATCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDTHREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLALPLPLSLLAAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	ARGQRPRTSAPSRAG HCCCCCCCCCCCHHH	31.74	-
17	Phosphorylation	RGQRPRTSAPSRAGA CCCCCCCCCCCHHHH	39.19	-
20	Phosphorylation	RPRTSAPSRAGALLL CCCCCCCCHHHHHHH	34.18	-
89	Phosphorylation	LPSTTMETQFPVSEG CCCCCEEEECCCCCC	25.37	30177828
94	Phosphorylation	METQFPVSEGKVDPY EEEECCCCCCCCCCC	40.65	30177828
133	N-linked_Glycosylation	WMVSVRANGTHICAG CEEEEEECCEEECCC	45.38	UniProtKB CARBOHYD
218	Phosphorylation	KLKQELKYSNYVRPI HHHHHHHCCCCCCCE	18.12	22468782
230	Phosphorylation	RPICLPGTDYVLKDH CCEECCCCCEEECCC	23.40	22468782
232	Phosphorylation	ICLPGTDYVLKDHSR EECCCCCEEECCCCC	13.91	22468782
279	N-linked_Glycosylation	ECDNFYHNFTKIPTL CCCCHHCCCCHHHHH	34.60	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSP50_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSP50_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSP50_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB1_HUMAN	TUBB1	physical	26186194
PRS46_HUMAN	PRSS46	physical	26186194
GRP78_HUMAN	HSPA5	physical	26186194
PIGT_HUMAN	PIGT	physical	26186194
ZY11B_HUMAN	ZYG11B	physical	26186194
PIGS_HUMAN	PIGS	physical	26186194
SPCS2_HUMAN	SPCS2	physical	26186194
FKB14_HUMAN	FKBP14	physical	26186194
FOXF1_HUMAN	FOXF1	physical	26186194
ATS1_HUMAN	ADAMTS1	physical	26186194
GPI8_HUMAN	PIGK	physical	26186194
GPAA1_HUMAN	GPAA1	physical	26186194
GNL3L_HUMAN	GNL3L	physical	26186194
TOR3A_HUMAN	TOR3A	physical	26186194
PIGU_HUMAN	PIGU	physical	26186194
PRS46_HUMAN	PRSS46	physical	28514442
TBB1_HUMAN	TUBB1	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
FKB14_HUMAN	FKBP14	physical	28514442
ATS1_HUMAN	ADAMTS1	physical	28514442
PIGS_HUMAN	PIGS	physical	28514442
UBP54_HUMAN	USP54	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
GPAA1_HUMAN	GPAA1	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
SPCS2_HUMAN	SPCS2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.