TOR3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOR3A_HUMAN
• UniProt AC: Q9H497
• Protein Name: Torsin-3A
• Gene Name: TOR3A
• Organism: Homo sapiens (Human).
• Sequence Length: 397
• Subcellular Localization: Cytoplasm. Endoplasmic reticulum lumen.
• Protein Sequence: MLRGPWRQLWLFFLLLLPGAPEPRGASRPWEGTDEPGSAWAWPGFQRLQEQLRAAGALSKRYWTLFSCQVWPDDCDEDEEAATGPLGWRLPLLGQRYLDLLTTWYCSFKDCCPRGDCRISNNFTGLEWDLNVRLHGQHLVQQLVLRTVRGYLETPQPEKALALSFHGWSGTGKNFVARMLVENLYRDGLMSDCVRMFIATFHFPHPKYVDLYKEQLMSQIRETQQLCHQTLFIFDEAEKLHPGLLEVLGPHLERRAPEGHRAESPWTIFLFLSNLRGDIINEVVLKLLKAGWSREEITMEHLEPHLQAEIVETIDNGFGHSRLVKENLIDYFIPFLPLEYRHVRLCARDAFLSQELLYKEETLDEIAQMMVYVPKEEQLFSSQGCKSISQRINYFLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	O-linked_Glycosylation	ASRPWEGTDEPGSAW CCCCCCCCCCCCCCC	26.19	OGP
60	Ubiquitination	RAAGALSKRYWTLFS HHCHHHHHHHHEEEE	50.81	-
73 (in isoform 3)	Ubiquitination	-	54.15	21906983
97	Phosphorylation	LPLLGQRYLDLLTTW CHHCCHHHHHHHHHH	9.18	-
105	Phosphorylation	LDLLTTWYCSFKDCC HHHHHHHCCCHHHHC	3.99	-
109 (in isoform 3)	Ubiquitination	-	33.30	21906983
109 (in isoform 2)	Ubiquitination	-	33.30	21906983
109 (in isoform 1)	Ubiquitination	-	33.30	21906983
109	Ubiquitination	TTWYCSFKDCCPRGD HHHCCCHHHHCCCCC	33.30	21906983
122	N-linked_Glycosylation	GDCRISNNFTGLEWD CCCEEECCCCCCEEE	29.12	UniProtKB CARBOHYD
151	Phosphorylation	VLRTVRGYLETPQPE HHHHHHHHHCCCCHH	7.27	24719451
159	Ubiquitination	LETPQPEKALALSFH HCCCCHHHCEEEEEE	56.22	-
169	Phosphorylation	ALSFHGWSGTGKNFV EEEEECCCCCCHHHH	30.94	24719451
173	Ubiquitination	HGWSGTGKNFVARML ECCCCCCHHHHHHHH	47.23	-
213	Ubiquitination	PKYVDLYKEQLMSQI HHHHHHHHHHHHHHH	46.40	22817900
213 (in isoform 2)	Ubiquitination	-	46.40	21906983
213 (in isoform 1)	Ubiquitination	-	46.40	21906983
223	Phosphorylation	LMSQIRETQQLCHQT HHHHHHHHHHHHHHH	16.27	27251275
230	Phosphorylation	TQQLCHQTLFIFDEA HHHHHHHHHHHCCHH	10.44	26126808
239	Ubiquitination	FIFDEAEKLHPGLLE HHCCHHHHHCCCHHH	60.17	21963094
264	Phosphorylation	PEGHRAESPWTIFLF CCCCCCCCHHHHEEH	25.42	25921289
273	Phosphorylation	WTIFLFLSNLRGDII HHHEEHHHCCCCCHH	26.87	24719451
286	Ubiquitination	IINEVVLKLLKAGWS HHHHHHHHHHHCCCC	39.91	22817900
289 (in isoform 1)	Ubiquitination	-	56.12	21906983
289	Ubiquitination	EVVLKLLKAGWSREE HHHHHHHHCCCCHHH	56.12	21906983
289 (in isoform 2)	Ubiquitination	-	56.12	21906983
325 (in isoform 1)	Ubiquitination	-	45.54	21906983
325	Ubiquitination	FGHSRLVKENLIDYF CCCHHHHHHHHHHHH	45.54	22817900
331	Phosphorylation	VKENLIDYFIPFLPL HHHHHHHHHHCCCCC	9.09	-
340	Phosphorylation	IPFLPLEYRHVRLCA HCCCCCCHHHHHHHH	17.44	-
353	Phosphorylation	CARDAFLSQELLYKE HHHHHHHCHHHHHCH	18.37	30622161
358	Phosphorylation	FLSQELLYKEETLDE HHCHHHHHCHHCHHH	29.04	30622161
362	Phosphorylation	ELLYKEETLDEIAQM HHHHCHHCHHHHHHH	40.37	30622161
386	Ubiquitination	LFSSQGCKSISQRIN HHCCCCHHHHHHHHH	58.61	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOR3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOR3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOR3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRP78_HUMAN	HSPA5	physical	26186194
TMM43_HUMAN	TMEM43	physical	26186194
OMA1_HUMAN	OMA1	physical	26186194
WRB_HUMAN	WRB	physical	26186194
OMA1_HUMAN	OMA1	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
CALX_HUMAN	CANX	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.