HGD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HGD_HUMAN
• UniProt AC: Q93099
• Protein Name: Homogentisate 1,2-dioxygenase
• Gene Name: HGD
• Organism: Homo sapiens (Human).
• Sequence Length: 445
• Protein Sequence: MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEICVIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPGGGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLDENYHKCWEPLKSHFTPNSRNPAEPN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	QVCPYNLYAEQLSGS CCCCCHHEEHHHCCC	12.40	-
67	Phosphorylation	WLYRILPSVSHKPFE HHHHHCCCCCCCCCC	32.57	24275569
98	Acetylation	DPNQLRWKPFEIPKA CCCCCCCCCCCCCCH	33.14	19608861
166	Phosphorylation	QKGNLLIYTEFGKML CCCCEEEEECCCCEE	10.53	-
167	Phosphorylation	KGNLLIYTEFGKMLV CCCEEEEECCCCEEC	20.18	-
244	Phosphorylation	RQVPGGYTVINKYQG CCCCCCEEEEEEECC	20.41	-
249	Phosphorylation	GYTVINKYQGKLFAA CEEEEEEECCEEEEE	20.29	24719451
296	Phosphorylation	AFDHADPSIFTVLTA ECCCCCCCCEEEEEE	30.77	19664995
302	Phosphorylation	PSIFTVLTAKSVRPG CCCEEEEEECCCCCC	27.92	19664995
333	Phosphorylation	DKTFRPPYYHRNCMS CCCCCCCCHHHHHHH	18.00	-
334	Phosphorylation	KTFRPPYYHRNCMSE CCCCCCCHHHHHHHH	10.48	-
414	Succinylation	AVTKWGLKASRCLDE HHHHHCHHHHHHHCC	40.14	-
414	Succinylation	AVTKWGLKASRCLDE HHHHHCHHHHHHHCC	40.14	-
416	O-linked_Glycosylation	TKWGLKASRCLDENY HHHCHHHHHHHCCCH	23.18	30379171
423	Phosphorylation	SRCLDENYHKCWEPL HHHHCCCHHHHCHHH	10.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HGD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HGD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HGD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCDGK_HUMAN	PCDHGC3	physical	21988832
HGD_HUMAN	HGD	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 203500: Alkaptonuria (AKU)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-98, AND MASS SPECTROMETRY.
PubMed: 19608861