PCDGK_HUMAN - dbPTM
PCDGK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDGK_HUMAN
UniProt AC Q9UN70
Protein Name Protocadherin gamma-C3
Gene Name PCDHGC3
Organism Homo sapiens (Human).
Sequence Length 934
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGEMFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELSRNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQVLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRVQVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFELTAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHTGQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIFKVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAESAPPGQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationWRSGLVSTGRVVGVL
HHCCCCCHHHHHHHH		22.8723403867
60PhosphorylationNLGLDLGSLSARRFR
HCCCCCCCCCCHHHE		26.8423401153
62PhosphorylationGLDLGSLSARRFRVV
CCCCCCCCCHHHEEC		22.7930266825
70PhosphorylationARRFRVVSGASRRFF
CHHHEECCCCCCEEE		26.2823911959
73PhosphorylationFRVVSGASRRFFEVN
HEECCCCCCEEEEEC		27.7523911959
145PhosphorylationQEMKLEISEAVAPGT
HHEEEEEECCCCCCC		15.3230576142
168PhosphorylationDPDVGSNSLQTYELS
CCCCCCCCEEEEECC		24.4530576142
172PhosphorylationGSNSLQTYELSRNEY
CCCCEEEEECCCCCE		11.2530576142
209PhosphorylationLDREREPSLQLVLTA
HHCCCCCCCEEEEEE		24.80-
245N-linked_GlycosylationNDNAPVFNQSLYRAR
CCCCCCCCHHHHHHH		30.66UniProtKB CARBOHYD
301PhosphorylationLFALDLVTGMLTIKG
HHHHHHHCCCEEEEC		24.9528509920
305PhosphorylationDLVTGMLTIKGRLDF
HHHCCCEEEECCCCC		16.2628509920
424N-linked_GlycosylationRETVPEYNLSITARD
CCCCCCCEEEEEEEC		26.17UniProtKB CARBOHYD
478N-linked_GlycosylationLPGAPILNLSVWDPD
CCCCCEEEEEEECCC		30.87UniProtKB CARBOHYD
509PhosphorylationETGLVGRYFTINRDN
CCCCCEEEEEEECCC		10.1128857561
511PhosphorylationGLVGRYFTINRDNGI
CCCEEEEEEECCCCE		14.3828857561
536PhosphorylationDRREFELTAHISDGG
CCCEEEEEEEECCCC		14.7024719451
550N-linked_GlycosylationGTPVLATNISVNIFV
CCEEEEEEEEEEEEE		20.94UniProtKB CARBOHYD
558PhosphorylationISVNIFVTDRNDNAP
EEEEEEECCCCCCCC		20.6324719451
575PhosphorylationLYPRPGGSSVEMLPR
EECCCCCCCEEEECC		36.8119664994
576PhosphorylationYPRPGGSSVEMLPRG
ECCCCCCCEEEECCC		25.93-
591PhosphorylationTSAGHLVSRVVGWDA
CCHHHHHHHHHCCCC		26.22-
615N-linked_GlycosylationYSLLGSPNQSLFAIG
HHCCCCCCCEEEEEE		45.85UniProtKB CARBOHYD
643O-linked_GlycosylationDTDSPRQTLTVLIKD
CCCCCCCEEEEEEEE		26.1955829517
645O-linked_GlycosylationDSPRQTLTVLIKDNG
CCCCCEEEEEEEECC		19.3655829521
689N-linked_GlycosylationAPREQKKNLTFYLLL
CCHHHHHHHHHHHHH		51.88UniProtKB CARBOHYD
691PhosphorylationREQKKNLTFYLLLSL
HHHHHHHHHHHHHHH		21.45-
693PhosphorylationQKKNLTFYLLLSLIL
HHHHHHHHHHHHHHH		7.39-
697PhosphorylationLTFYLLLSLILVSVG
HHHHHHHHHHHHHHH		17.21-
732PhosphorylationDLYRAPVSSLYRTPG
CCCCCCHHHHCCCCC		17.3630266825
733PhosphorylationLYRAPVSSLYRTPGP
CCCCCHHHHCCCCCC		29.6530266825
735PhosphorylationRAPVSSLYRTPGPSL
CCCHHHHCCCCCCCC		17.8725884760
737PhosphorylationPVSSLYRTPGPSLHA
CHHHHCCCCCCCCCH		21.0223403867
753PhosphorylationAVRGGLMSPHLYHQV
HHCCCCCCHHHEEEE		17.7626356563
757PhosphorylationGLMSPHLYHQVYLTT
CCCCHHHEEEEEEEC		6.2826356563
761PhosphorylationPHLYHQVYLTTDSRR
HHHEEEEEEECCCCC		7.5526356563
766PhosphorylationQVYLTTDSRRSDPLL
EEEEECCCCCCCCCC		27.7424961811
769PhosphorylationLTTDSRRSDPLLKKP
EECCCCCCCCCCCCC		42.3330266825
780PhosphorylationLKKPGAASPLASRQN
CCCCCCCCCCHHHCC		21.6630266825
784PhosphorylationGAASPLASRQNTLRS
CCCCCCHHHCCCHHC		41.9230266825
788PhosphorylationPLASRQNTLRSCDPV
CCHHHCCCHHCCCHH		18.40-
791PhosphorylationSRQNTLRSCDPVFYR
HHCCCHHCCCHHHHH		26.4525850435
797PhosphorylationRSCDPVFYRQVLGAE
HCCCHHHHHHHHCCC		10.6025884760
821PhosphorylationPNTDWRFSQAQRPGT
CCCCCCCCCCCCCCC		18.9425003641
881PhosphorylationTMGLSARYGPQFTLQ
CCCCCCCCCCCEEEE		32.6425884760
886PhosphorylationARYGPQFTLQHVPDY
CCCCCCEEEEECCCC		21.9124961811
893PhosphorylationTLQHVPDYRQNVYIP
EEEECCCCCCCEEEC		14.1824927040
898PhosphorylationPDYRQNVYIPGSNAT
CCCCCCEEECCCCCE		14.6725884760
902PhosphorylationQNVYIPGSNATLTNA
CCEEECCCCCEECCC		20.2424719451
905PhosphorylationYIPGSNATLTNAAGK
EECCCCCEECCCCCC		38.0627050516
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDGK_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDGK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDGK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
PCDGF_HUMANPCDHGB3physical
28514442
GRTP1_HUMANGRTP1physical
28514442
NRN1_HUMANNRN1physical
28514442
SPTN4_HUMANSPTBN4physical
28514442
EEPD1_HUMANEEPD1physical
28514442
ERIC5_HUMANERICH5physical
28514442
SRC_HUMANSRCphysical
28514442
CNTN1_HUMANCNTN1physical
28514442
PTPRG_HUMANPTPRGphysical
28514442
PHAG1_HUMANPAG1physical
28514442
FYN_HUMANFYNphysical
28514442
RASH_HUMANHRASphysical
28514442
NEUM_HUMANGAP43physical
28514442
UBTD2_HUMANUBTD2physical
28514442
CDCA3_HUMANCDCA3physical
28514442
YES_HUMANYES1physical
28514442
GNAZ_HUMANGNAZphysical
28514442
EPCR_HUMANPROCRphysical
28514442
GNAQ_HUMANGNAQphysical
28514442
ACHA9_HUMANCHRNA9physical
28514442
CD109_HUMANCD109physical
28514442
AHNK_HUMANAHNAKphysical
28514442
CADH1_HUMANCDH1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDGK_HUMAN

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Related Literatures of Post-Translational Modification

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