PCDGF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDGF_HUMAN
• UniProt AC: Q9Y5G1
• Protein Name: Protocadherin gamma-B3
• Gene Name: PCDHGB3
• Organism: Homo sapiens (Human).
• Sequence Length: 929
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MGNSSGWRGPAGQRRMLFLFLLSLLDQALSEPIRYAIPEELDRGSLVGNLAKDLGFGVGDLPTRNLRVIAEKKFFTVSPENGNLLVSDRIDREEICGKKSTCVLEFEMVAEKPLNFFHVTVLIQDINDNPPTFSQNITELEISELALTGATFALESAQDPDVGVNSLQQYYLSPDPHFSLIQKENLDGSRYPELVLKAPLDREEQPHHHLVLTAVDGGEPSRSCTTQIRVIVADANDNPPVFTQDMYRVNVAENLPAGSSVLKVMAIDMDEGINAEIIYAFINIGKEVRQLFKLDSKTGELTTIGELDFEERDSYTIGVEAKDGGHHTAYCKVQIDISDENDNAPEITLASESQHIQEDAELGTAVALIKTHDLDSGFNGEILCQLKGNFPFKIVQDTKNTYRLVTDGALDREQIPEYNVTITATDKGNPPLSSSKTITLHILDVNDNVPVFHQASYTVHVAENNPPGASIAHVRASDPDLGPNGLVSYYIVASDLEPRELSSYVSVSARSGVVFAQRAFDHEQLRAFELTLQARDQGSPTLSANVSLRVLVDDRNDNAPLVLYPALGPEGSALFDMVPRSAEPGYLVTKVVAVDADSGYNAWLSYHIVQASEPGLFSLGLRTGEVRTARTLGDREAARQRLLVTVRDGGQQPLSATVMLHLIFADSLQEIQPDLSDRPTPSDPQAELQFHLVVALALISVLFLLAVILAISLRLRCSSRPATEGYFQPGVCFKTVPGVLPTYSERTLPYSYNPCAASHSSNTEFKFLNIKAENAAPQDLLCDEASWFESNDNPEMPSNSGNLQKQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	IAEKKFFTVSPENGN EEEEECEEECCCCCC	24.17	29083192
78	Phosphorylation	EKKFFTVSPENGNLL EEECEEECCCCCCEE	24.36	29083192
87	Phosphorylation	ENGNLLVSDRIDREE CCCCEEEECCCCHHH	22.57	29083192
136	N-linked_Glycosylation	NPPTFSQNITELEIS CCCCHHCCCEEEHHH	41.78	UniProtKB CARBOHYD
302	Phosphorylation	DSKTGELTTIGELDF CCCCCCEEEEEECCC	16.44	-
418	Phosphorylation	DREQIPEYNVTITAT CHHHCCCCEEEEEEC	15.02	-
419	N-linked_Glycosylation	REQIPEYNVTITATD HHHCCCCEEEEEECC	23.85	UniProtKB CARBOHYD
421	Phosphorylation	QIPEYNVTITATDKG HCCCCEEEEEECCCC	14.69	-
502	Phosphorylation	DLEPRELSSYVSVSA CCCCCCCHHCEEEEE	18.18	19835603
504	Phosphorylation	EPRELSSYVSVSARS CCCCCHHCEEEEECC	8.05	19835603
511	Phosphorylation	YVSVSARSGVVFAQR CEEEEECCCEEEEEE	35.34	19835603
545	N-linked_Glycosylation	GSPTLSANVSLRVLV CCCCEEEEEEEEEEE	22.12	UniProtKB CARBOHYD
816	Phosphorylation	PNTDWRFSQAQRPGT CCCCCCCEECCCCCC	18.94	25003641
876	Phosphorylation	TMGLSARYGPQFTLQ CCCCCCCCCCCEEEE	32.64	25884760
881	Phosphorylation	ARYGPQFTLQHVPDY CCCCCCEEEEECCCC	21.91	24961811
888	Phosphorylation	TLQHVPDYRQNVYIP EEEECCCCCCCEEEC	14.18	24927040
893	Phosphorylation	PDYRQNVYIPGSNAT CCCCCCEEECCCCCE	14.67	25884760
897	Phosphorylation	QNVYIPGSNATLTNA CCEEECCCCCEECCC	20.24	24719451
900	Phosphorylation	YIPGSNATLTNAAGK EECCCCCEECCCCCC	38.06	27050516
907	Ubiquitination	TLTNAAGKRDGKAPA EECCCCCCCCCCCCC	42.46	32142685
911	Ubiquitination	AAGKRDGKAPAGGNG CCCCCCCCCCCCCCC	56.33	32142685
920	Ubiquitination	PAGGNGNKKKSGKKE CCCCCCCCCCCCCCC	64.08	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDGF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDGF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDGF_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCDGF_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.