NRN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRN1_HUMAN
• UniProt AC: Q9NPD7
• Protein Name: Neuritin
• Gene Name: NRN1
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . Cell junction, synapse.
• Protein Description: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells..
• Protein Sequence: MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLKLGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLNIQGSLFELCGSGNGAAGSLLPAFPVLLVSLSAALATWLSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	DAVFKGFSDCLLKLG CCHHCCHHHHHHHHH	35.76	22985185
52	Phosphorylation	LGDSMANYPQGLDDK HHHHHHHCCCCCCCC	6.33	-
76	O-linked_Glycosylation	WEDFHSCTVTALTDC HHHHHHCEEEEEECC	24.73	OGP
78	Phosphorylation	DFHSCTVTALTDCQE HHHHCEEEEEECCCH	9.59	-
78	O-linked_Glycosylation	DFHSCTVTALTDCQE HHHHCEEEEEECCCH	9.59	OGP
116	GPI-anchor	ELCGSGNGAAGSLLP HHCCCCCCHHHHHHC	21.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S12A6_HUMAN	SLC12A6	physical	28514442
S12A7_HUMAN	SLC12A7	physical	28514442
TM219_HUMAN	TMEM219	physical	28514442
S12A4_HUMAN	SLC12A4	physical	28514442
AT11C_HUMAN	ATP11C	physical	28514442
FZD2_HUMAN	FZD2	physical	28514442
EAA3_HUMAN	SLC1A1	physical	28514442
GLRB_HUMAN	GLRB	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
S47A1_HUMAN	SLC47A1	physical	28514442
GPC3_HUMAN	GPC3	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442
AGRL1_HUMAN	LPHN1	physical	28514442
SPCS2_HUMAN	SPCS2	physical	28514442
SPP2B_HUMAN	SPPL2B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.