dbPTM

S12A7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	S12A7_HUMAN
UniProt AC	Q9Y666
Protein Name	Solute carrier family 12 member 7
Gene Name	SLC12A7
Organism	Homo sapiens (Human).
Sequence Length	1083
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)..
Protein Sequence	MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAFDPPDIPVCLLGNRTLSRRSFDACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNNVTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPTNFTVVPV -----CCCCEEEEEE	55.62	29759185
6	Phosphorylation	--MPTNFTVVPVEAH --CCCCEEEEEEEEE	23.74	29759185
21	Phosphorylation	ADGGGDETAERTEAP CCCCCCCCCCCCCCC	38.26	25002506
25	Phosphorylation	GDETAERTEAPGTPE CCCCCCCCCCCCCCC	28.18	30278072
30	Phosphorylation	ERTEAPGTPEGPEPE CCCCCCCCCCCCCCC	19.67	23401153
40	Phosphorylation	GPEPERPSPGDGNPR CCCCCCCCCCCCCCC	47.97	30266825
50	Phosphorylation	DGNPRENSPFLNNVE CCCCCCCCCCCCCCE	16.57	30278072
62	Phosphorylation	NVEVEQESFFEGKNM CCEECEEHHHCCCCC	34.62	21712546
78	Phosphorylation	LFEEEMDSNPMVSSL HHHHHHCCCHHHHHH	41.33	26657352
83	Phosphorylation	MDSNPMVSSLLNKLA HCCCHHHHHHHHHHH	14.71	27732954
84	Phosphorylation	DSNPMVSSLLNKLAN CCCHHHHHHHHHHHC	26.01	24719451
92	Phosphorylation	LLNKLANYTNLSQGV HHHHHHCCCCCCCCC	7.44	25884760
93	Phosphorylation	LNKLANYTNLSQGVV HHHHHCCCCCCCCCC	29.50	28152594
96	Phosphorylation	LANYTNLSQGVVEHE HHCCCCCCCCCCCCC	27.27	20873877
108	Phosphorylation	EHEEDEESRRREAKA CCCCCHHHHHHHHHC	29.10	30266825
312	N-linked_Glycosylation	IPVCLLGNRTLSRRS CCEEEECCCCCCHHH	33.46	UniProtKB CARBOHYD
360	N-linked_Glycosylation	DEYFIQNNVTEIQGI HHHHHHCCCEEECCC	26.22	UniProtKB CARBOHYD
377	Ubiquitination	AASGVFLENLWSTYA CCCCHHHHHHHHHHC	38.52	27667366
393	Ubiquitination	AGAFVEKKGVPSVPV CCCCCCCCCCCCCCC	52.19	-
431	Ubiquitination	VGIYFPSVTGIMAGS HHHHCCCCCEECCCC	6.06	27667366
442	Ubiquitination	MAGSNRSGDLKDAQK CCCCCCCCCHHHHHH	40.82	27667366
445	Ubiquitination	SNRSGDLKDAQKSIP CCCCCCHHHHHHCCC	56.61	27667366
468	Ubiquitination	TTSFIYLSCIVLFGA CHHHHHHHHHHHHHH	5.71	27667366
620	Ubiquitination	FYHWTLSFLGMSLCL HHHHHHHHHHHHHHH	8.43	22817900
669	Phosphorylation	GDGIRGLSLNAARYA CCCHHHHHHHHHHHH	23.54	23312004
674	Ubiquitination	GLSLNAARYALLRVE HHHHHHHHHHHHHCC	18.17	22817900
685	Ubiquitination	LRVEHGPPHTKNWRP HHCCCCCCCCCCCCC	52.99	22817900
688	Ubiquitination	EHGPPHTKNWRPQVL CCCCCCCCCCCCEEE	52.02	22817900
711	Ubiquitination	QAVKHPRLLSFTSQL HHHCCHHHHHHHCCC	5.75	22817900
715	Phosphorylation	HPRLLSFTSQLKAGK CHHHHHHHCCCCCCC	16.52	-
716	Phosphorylation	PRLLSFTSQLKAGKG HHHHHHHCCCCCCCC	31.35	-
735	Phosphorylation	GSVLEGTYLDKHMEA EEEEECCCHHHHHHH	24.62	-
757	Ubiquitination	RSLMSTEKTKGFCQL HHHHHCCCCCCCCHH	56.47	29967540
759	Ubiquitination	LMSTEKTKGFCQLVV HHHCCCCCCCCHHHH	62.14	-
780	Phosphorylation	GMSHLIQSAGLGGLK HHHHHHHHCCCCCCC	19.81	24719451
790	Phosphorylation	LGGLKHNTVLMAWPA CCCCCCCEEEEEEEC	18.09	24719451
798	Phosphorylation	VLMAWPASWKQEDNP EEEEEECCCCCCCCC	30.63	24719451
800	Ubiquitination	MAWPASWKQEDNPFS EEEECCCCCCCCCCC	41.12	32015554
809	Ubiquitination	EDNPFSWKNFVDTVR CCCCCCHHHHHHHHH	39.03	29967540
824	Ubiquitination	DTTAAHQALLVAKNV HCHHHHHHHHHCCCC	7.94	23000965
825	Ubiquitination	TTAAHQALLVAKNVD CHHHHHHHHHCCCCC	2.96	23000965
869	Ubiquitination	PFLLRQHKVWRKCRM HHHHHHHHHHHHHCC	34.84	21890473
875	Ubiquitination	HKVWRKCRMRIFTVA HHHHHHHCCEEEEEE	22.05	21890473
878	Ubiquitination	WRKCRMRIFTVAQVD HHHHCCEEEEEEEEC	2.19	23000965
879	Ubiquitination	RKCRMRIFTVAQVDD HHHCCEEEEEEEECC	2.95	23000965
889	Ubiquitination	AQVDDNSIQMKKDLQ EEECCCCCCCHHHHH	6.10	23000965
890	Ubiquitination	QVDDNSIQMKKDLQM EECCCCCCCHHHHHH	37.15	23000965
892	Ubiquitination	DDNSIQMKKDLQMFL CCCCCCCHHHHHHHH	27.10	23000965
893	Ubiquitination	DNSIQMKKDLQMFLY CCCCCCHHHHHHHHH	59.33	23000965
908	Ubiquitination	HLRISAEVEVVEMVE HHHHCCEEEEEECCC	7.27	21890473
915	Ubiquitination	VEVVEMVENDISAFT EEEEECCCCCHHHHH	48.12	23000965
916	Ubiquitination	EVVEMVENDISAFTY EEEECCCCCHHHHHH	40.27	23000965
917	Ubiquitination	VVEMVENDISAFTYE EEECCCCCHHHHHHH	23.78	22817900
922	Ubiquitination	ENDISAFTYERTLMM CCCHHHHHHHHHHHH	24.96	21890473
923	Ubiquitination	NDISAFTYERTLMME CCHHHHHHHHHHHHH	9.28	21890473
926	Phosphorylation	SAFTYERTLMMEQRS HHHHHHHHHHHHHHH	13.68	23401153
929	Ubiquitination	TYERTLMMEQRSQML HHHHHHHHHHHHHHH	4.45	21890473
933	Phosphorylation	TLMMEQRSQMLKQMQ HHHHHHHHHHHHHHH	21.45	28857561
934	Ubiquitination	LMMEQRSQMLKQMQL HHHHHHHHHHHHHHC	43.34	21890473
937	Ubiquitination	EQRSQMLKQMQLSKN HHHHHHHHHHHCCCC	38.08	23000965
937 (in isoform 1)	Ubiquitination	-	38.08	21890473
940	Ubiquitination	SQMLKQMQLSKNEQE HHHHHHHHCCCCHHH	39.84	21890473
943	Ubiquitination	LKQMQLSKNEQEREA HHHHHCCCCHHHHHH	73.44	23000965
943 (in isoform 1)	Ubiquitination	-	73.44	21890473
958	Phosphorylation	QLIHDRNTASHTAAA HHHCCCCHHHHHHHH	30.36	20068231
960	Phosphorylation	IHDRNTASHTAAAAR HCCCCHHHHHHHHHH	21.23	20068231
960	Ubiquitination	IHDRNTASHTAAAAR HCCCCHHHHHHHHHH	21.23	21890473
962	Phosphorylation	DRNTASHTAAAARTQ CCCHHHHHHHHHHCC	18.59	20068231
962	Ubiquitination	DRNTASHTAAAARTQ CCCHHHHHHHHHHCC	18.59	21890473
966	Ubiquitination	ASHTAAAARTQAPPT HHHHHHHHHCCCCCC	15.44	21890473
968	Phosphorylation	HTAAAARTQAPPTPD HHHHHHHCCCCCCCC	25.10	23403867
971	Ubiquitination	AAARTQAPPTPDKVQ HHHHCCCCCCCCCEE	24.39	22817900
973	Phosphorylation	ARTQAPPTPDKVQMT HHCCCCCCCCCEEEE	42.96	23401153
973	Ubiquitination	ARTQAPPTPDKVQMT HHCCCCCCCCCEEEE	42.96	21890473
976	Ubiquitination	QAPPTPDKVQMTWTR CCCCCCCCEEEEEEH	35.25	23000965
976 (in isoform 1)	Ubiquitination	-	35.25	21890473
980	Phosphorylation	TPDKVQMTWTREKLI CCCCEEEEEEHHHHH	13.44	19664994
982	Phosphorylation	DKVQMTWTREKLIAE CCEEEEEEHHHHHHH	21.56	30266825
982	Ubiquitination	DKVQMTWTREKLIAE CCEEEEEEHHHHHHH	21.56	22817900
983	Ubiquitination	KVQMTWTREKLIAEK CEEEEEEHHHHHHHH	30.52	23503661
985	Ubiquitination	QMTWTREKLIAEKYR EEEEEHHHHHHHHHH	41.73	22817900
987	Ubiquitination	TWTREKLIAEKYRSR EEEHHHHHHHHHHCC	7.43	21890473
988	Ubiquitination	WTREKLIAEKYRSRD EEHHHHHHHHHHCCC	20.05	23000965
990	Ubiquitination	REKLIAEKYRSRDTS HHHHHHHHHHCCCCC	36.62	27667366
990 (in isoform 1)	Ubiquitination	-	36.62	21890473
991	Phosphorylation	EKLIAEKYRSRDTSL HHHHHHHHHCCCCCC	12.82	25839225
993	Phosphorylation	LIAEKYRSRDTSLSG HHHHHHHCCCCCCCC	31.27	28857561
994	Ubiquitination	IAEKYRSRDTSLSGF HHHHHHCCCCCCCCC	42.08	23000965
996	Phosphorylation	EKYRSRDTSLSGFKD HHHHCCCCCCCCCHH	30.38	30266825
997	Phosphorylation	KYRSRDTSLSGFKDL HHHCCCCCCCCCHHH	25.48	23401153
999	Phosphorylation	RSRDTSLSGFKDLFS HCCCCCCCCCHHHHC	41.78	30266825
999	Ubiquitination	RSRDTSLSGFKDLFS HCCCCCCCCCHHHHC	41.78	21890473
1002	Ubiquitination	DTSLSGFKDLFSMKP CCCCCCCHHHHCCCC	57.98	23000965
1002 (in isoform 1)	Ubiquitination	-	57.98	21890473
1005	Ubiquitination	LSGFKDLFSMKPDQS CCCCHHHHCCCCCCC	10.86	23000965
1006	Phosphorylation	SGFKDLFSMKPDQSN CCCHHHHCCCCCCCC	32.94	24719451
1008	Ubiquitination	FKDLFSMKPDQSNVR CHHHHCCCCCCCCCC	44.22	23000965
1008 (in isoform 1)	Ubiquitination	-	44.22	21890473
1012	Phosphorylation	FSMKPDQSNVRRMHT HCCCCCCCCCCHHHH	44.68	-
1013	Ubiquitination	SMKPDQSNVRRMHTA CCCCCCCCCCHHHHE	26.19	21890473
1025	Ubiquitination	HTAVKLNGVVLNKSQ HHEEEECCEEECCCC	22.73	23000965
1030	Ubiquitination	LNGVVLNKSQDAQLV ECCEEECCCCCCEEE	45.38	-
1031	Ubiquitination	NGVVLNKSQDAQLVL CCEEECCCCCCEEEE	32.02	23000965
1037	Ubiquitination	KSQDAQLVLLNMPGP CCCCCEEEEECCCCC	3.67	23503661
1046	Ubiquitination	LNMPGPPKNRQGDEN ECCCCCCCCCCCCCC	68.82	23503661
1048	Ubiquitination	MPGPPKNRQGDENYM CCCCCCCCCCCCCHH	48.24	23503661
1051	Ubiquitination	PPKNRQGDENYMEFL CCCCCCCCCCHHHHH	32.41	23503661
1074	Ubiquitination	RVLLVRGGGREVITI CEEEEECCCEEEEEE	22.78	23503661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
973	T	Phosphorylation	Kinase	STK39	Q9UEW8	GPS
980	T	Phosphorylation	Kinase	STK39	Q9UEW8	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of S12A7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of S12A7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of S12A7_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00761	Potassium Chloride

Regulatory Network of S12A7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-62, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50 AND SER-62, AND MASSSPECTROMETRY.	18669648 [Abstract]