TM219_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM219_HUMAN
• UniProt AC: Q86XT9
• Protein Name: Insulin-like growth factor-binding protein 3 receptor
• Gene Name: TMEM219
• Organism: Homo sapiens (Human).
• Sequence Length: 240
• Subcellular Localization: Cell membrane ; Single-pass membrane protein .
• Protein Description: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding..
• Protein Sequence: MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGLLCCVTAMCFHPRRESHWSRTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	DWVSFLRSFGQLTLC HHHHHHHHHCCEEEE	35.56	27251275
73	N-linked_Glycosylation	QLTLCPRNGTVTGKW CEEEECCCCEECEEE	35.31	UniProtKB CARBOHYD
79	Ubiquitination	RNGTVTGKWRGSHVV CCCEECEEECCCEEE	25.09	-
101	N-linked_Glycosylation	FGDGPDRNKTRTFQA CCCCCCCCCCEEEEE	58.38	UniProtKB CARBOHYD
167	N-linked_Glycosylation	CSEEGAGNATLSPRM CCCCCCCCCEECCCC	29.26	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM219_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM219_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM219_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM219_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.