GLRB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLRB_HUMAN
• UniProt AC: P48167
• Protein Name: Glycine receptor subunit beta
• Gene Name: GLRB
• Organism: Homo sapiens (Human).
• Sequence Length: 497
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Retained in the cytoplasm upon heterologous expression b
• Protein Description: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. [PubMed: 8717357]
• Protein Sequence: MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Acetylation	YSKEKSSKKGKGKKK HHHHCCCCCCCCCCC	73.05	164297
31	Acetylation	EKSSKKGKGKKKQYL HCCCCCCCCCCCCCC	76.16	164301
34	Acetylation	SKKGKGKKKQYLCPS CCCCCCCCCCCCCCC	54.50	164305
35	Acetylation	KKGKGKKKQYLCPSQ CCCCCCCCCCCCCCC	47.89	164309
54	N-linked_Glycosylation	DLARVPANSTSNILN HHHCCCCCCHHHHHH	39.49	UniProtKB CARBOHYD
117	Ubiquitination	KWNDPRLKLPSDFRG CCCCCCCCCCCCCCC	60.68	29967540
125	Phosphorylation	LPSDFRGSDALTVDP CCCCCCCCCCCCCCH	18.56	-
129	Phosphorylation	FRGSDALTVDPTMYK CCCCCCCCCCHHHHH	25.28	-
136	Ubiquitination	TVDPTMYKCLWKPDL CCCHHHHHHHCCCCE	16.42	-
140	Ubiquitination	TMYKCLWKPDLFFAN HHHHHHCCCCEEECC	18.73	-
178	Phosphorylation	VLVSMRLSITLSCPL EEEEEEEEEEEECCC	11.80	22210691
188	Phosphorylation	LSCPLDLTLFPMDTQ EECCCCEEEEECCHH	26.48	22210691
194	Phosphorylation	LTLFPMDTQRCKMQL EEEEECCHHHHHHHH	16.20	22210691
198	Ubiquitination	PMDTQRCKMQLESFG ECCHHHHHHHHHHCC	31.69	-
203	Phosphorylation	RCKMQLESFGYTTDD HHHHHHHHCCCCHHC	32.34	-
206	Phosphorylation	MQLESFGYTTDDLRF HHHHHCCCCHHCEEE	12.40	-
242	N-linked_Glycosylation	KEDIEYGNCTKYYKG HHHCCCCCCCEEECC	29.41	UniProtKB CARBOHYD
261	Phosphorylation	TCVEVIFTLRRQVGF EEEEHHHHHHHHHCH	14.29	24719451
274	Phosphorylation	GFYMMGVYAPTLLIV CHHHHCCHHHHHHHH	10.92	-
277	Phosphorylation	MMGVYAPTLLIVVLS HHCCHHHHHHHHHHH	26.48	-
369	Ubiquitination	AEKARIAKAEQADGK HHHHHHHHHHHCCCC	50.51	-
391	Phosphorylation	NTVNGTGTPVHISTL CCCCCCCCEEEEEEE	23.21	24076635
411	Phosphorylation	RCKKVCTSKSDLRSN EECEEECCHHHHHCC	25.65	-
435	Phosphorylation	RDFELSNYDCYGKPI CCEECCCCEECCCEE	12.19	22817900
440	Ubiquitination	SNYDCYGKPIEVNNG CCCEECCCEEEECCC	19.15	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
435	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLRB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLRB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GEPH_HUMAN	GPHN	physical	7546736

Drug and Disease Associations

• Kegg Disease
• H00769: Hyperekplexia
• OMIM Disease
• 614619: Hyperekplexia 2 (HKPX2)
• Kegg Drug
• D00011: Glycine (JP16/USP)
• DrugBank
• There are no disease associations of PTM sites.