dbPTM

ACHA9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACHA9_HUMAN
UniProt AC	Q9UGM1
Protein Name	Neuronal acetylcholine receptor subunit alpha-9
Gene Name	CHRNA9
Organism	Homo sapiens (Human).
Sequence Length	479
Subcellular Localization	Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein . Cell membrane Multi-pass membrane protein .
Protein Description	Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. [PubMed: 11752216]
Protein Sequence	MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	EDTDKVLNVTLQITL CCCHHHHEEEEEEEH	27.93	UniProtKB CARBOHYD
65	Phosphorylation	VTLQITLSQIKDMDE EEEEEEHHHCCCHHH	22.62	24719451
122	Ubiquitination	PDIVLYNKADDESSE CCEEEEECCCCCCCC	39.37	21963094
170	N-linked_Glycosylation	PFDNQQCNLTFGSWT CCCCCEEEEEEEEEE	37.47	UniProtKB CARBOHYD
357	Phosphorylation	FVYDVGESCLSPHHS EEEECCHHHCCCCHH	17.90	28348404
360	Phosphorylation	DVGESCLSPHHSRER ECCHHHCCCCHHHCH	26.89	28348404
374	Phosphorylation	RDHLTKVYSKLPESN HHHHHHHHHHCCHHH	11.14	21712546
375	Phosphorylation	DHLTKVYSKLPESNL HHHHHHHHHCCHHHH	30.61	21712546
376	Ubiquitination	HLTKVYSKLPESNLK HHHHHHHHCCHHHHH	50.83	-
380	Phosphorylation	VYSKLPESNLKAARN HHHHCCHHHHHHHHC	45.59	21712546
383	Ubiquitination	KLPESNLKAARNKDL HCCHHHHHHHHCCCH	44.22	29967540
409	Ubiquitination	NDLGCQGKNPQEAES HHCCCCCCCHHHHHH	39.31	21963094
422	Ubiquitination	ESYCAQYKVLTRNIE HHHHHHHHHHHHCHH	20.77	-
430	Phosphorylation	VLTRNIEYIAKCLKD HHHHCHHHHHHHHHH	11.46	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACHA9_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ACHA9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACHA9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P121A_HUMAN	POM121	physical	26186194
T131L_HUMAN	KIAA0922	physical	26186194
FA76B_HUMAN	FAM76B	physical	26186194
NUFP2_HUMAN	NUFIP2	physical	26186194
ZNT1_HUMAN	SLC30A1	physical	26186194
CYTSA_HUMAN	SPECC1L	physical	26186194
S12A9_HUMAN	SLC12A9	physical	26186194
TMX2_HUMAN	TMX2	physical	26186194
METL9_HUMAN	METTL9	physical	26186194
NETO2_HUMAN	NETO2	physical	26186194
KINH_HUMAN	KIF5B	physical	26186194
KIF5A_HUMAN	KIF5A	physical	26186194
CA043_HUMAN	C1orf43	physical	26186194
CCPG1_HUMAN	CCPG1	physical	26186194
PMGT2_HUMAN	POMGNT2	physical	26186194
CKAP4_HUMAN	CKAP4	physical	26186194
TM39B_HUMAN	TMEM39B	physical	26186194
KLC2_HUMAN	KLC2	physical	26186194
KLC4_HUMAN	KLC4	physical	26186194
DHRS7_HUMAN	DHRS7	physical	26186194
ZNT5_HUMAN	SLC30A5	physical	26186194
LRC59_HUMAN	LRRC59	physical	26186194
DIA1_HUMAN	C3orf58	physical	26186194
PBIP1_HUMAN	PBXIP1	physical	26186194
CISD2_HUMAN	CISD2	physical	26186194
CELR1_HUMAN	CELSR1	physical	26186194
LEMD2_HUMAN	LEMD2	physical	26186194
LNP_HUMAN	KIAA1715	physical	26186194
GOLM1_HUMAN	GOLM1	physical	26186194
RNC_HUMAN	DROSHA	physical	26186194
GHDC_HUMAN	GHDC	physical	26186194
BT2A2_HUMAN	BTN2A2	physical	26186194
HS2ST_HUMAN	HS2ST1	physical	26186194
HYEP_HUMAN	EPHX1	physical	26186194
HMOX1_HUMAN	HMOX1	physical	26186194
GRM1A_HUMAN	GRAMD1A	physical	26186194
ATF6B_HUMAN	ATF6B	physical	26186194
HMDH_HUMAN	HMGCR	physical	26186194
TMUB1_HUMAN	TMUB1	physical	26186194
MACOI_HUMAN	TMEM57	physical	26186194
CHK1_HUMAN	CHEK1	physical	26186194
ZNT6_HUMAN	SLC30A6	physical	26186194
AT11C_HUMAN	ATP11C	physical	26186194
H6ST1_HUMAN	HS6ST1	physical	26186194
FUT8_HUMAN	FUT8	physical	26186194
ZDHC9_HUMAN	ZDHHC9	physical	26186194
PDE3B_HUMAN	PDE3B	physical	26186194
TM39A_HUMAN	TMEM39A	physical	26186194
SNX14_HUMAN	SNX14	physical	26186194
ZNT7_HUMAN	SLC30A7	physical	26186194
PDZD8_HUMAN	PDZD8	physical	26186194
DJC18_HUMAN	DNAJC18	physical	26186194
ERGI2_HUMAN	ERGIC2	physical	26186194
RER1_HUMAN	RER1	physical	26186194
YKT6_HUMAN	YKT6	physical	26186194
MAVS_HUMAN	MAVS	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
TIM29_HUMAN	C19orf52	physical	26186194
DDRGK_HUMAN	DDRGK1	physical	26186194
E2AK3_HUMAN	EIF2AK3	physical	26186194
ST7_HUMAN	ST7	physical	26186194
T120B_HUMAN	TMEM120B	physical	26186194
MAP7_HUMAN	MAP7	physical	26186194
DJC30_HUMAN	DNAJC30	physical	26186194
LCLT1_HUMAN	LCLAT1	physical	26186194
CHK1_HUMAN	CHEK1	physical	28514442
KLC4_HUMAN	KLC4	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
TIM29_HUMAN	C19orf52	physical	28514442
DJC18_HUMAN	DNAJC18	physical	28514442
ZNT5_HUMAN	SLC30A5	physical	28514442
GOLM1_HUMAN	GOLM1	physical	28514442
DJC30_HUMAN	DNAJC30	physical	28514442
ZNT6_HUMAN	SLC30A6	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
PBIP1_HUMAN	PBXIP1	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
LEMD2_HUMAN	LEMD2	physical	28514442
SNX14_HUMAN	SNX14	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
YKT6_HUMAN	YKT6	physical	28514442
GHDC_HUMAN	GHDC	physical	28514442
MAP7_HUMAN	MAP7	physical	28514442
RNC_HUMAN	DROSHA	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442
H6ST1_HUMAN	HS6ST1	physical	28514442
CCPG1_HUMAN	CCPG1	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
T120B_HUMAN	TMEM120B	physical	28514442
TM268_HUMAN	C9orf91	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
TM39B_HUMAN	TMEM39B	physical	28514442
GRM1A_HUMAN	GRAMD1A	physical	28514442
ST7_HUMAN	ST7	physical	28514442
P121A_HUMAN	POM121	physical	28514442
BT2A2_HUMAN	BTN2A2	physical	28514442
KIF5A_HUMAN	KIF5A	physical	28514442
METL9_HUMAN	METTL9	physical	28514442
ZNT7_HUMAN	SLC30A7	physical	28514442
TM39A_HUMAN	TMEM39A	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
TMUB1_HUMAN	TMUB1	physical	28514442
PDE3B_HUMAN	PDE3B	physical	28514442
DDRGK_HUMAN	DDRGK1	physical	28514442
CYTSA_HUMAN	SPECC1L	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACHA9_HUMAN

Related Literatures of Post-Translational Modification