| UniProt ID | S12A9_HUMAN | |
|---|---|---|
| UniProt AC | Q9BXP2 | |
| Protein Name | Solute carrier family 12 member 9 | |
| Gene Name | SLC12A9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 914 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.. | |
| Protein Sequence | MASESSPLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANALVRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHGVTPVTCTDL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASESSPLLA -----CCCCCCCHHH | 36.39 | 30108239 | |
| 5 | Phosphorylation | ---MASESSPLLAYR ---CCCCCCCHHHHH | 34.46 | 29255136 | |
| 6 | Phosphorylation | --MASESSPLLAYRL --CCCCCCCHHHHHH | 18.60 | 29255136 | |
| 11 | Phosphorylation | ESSPLLAYRLLGEEG CCCCHHHHHHHCCCC | 11.19 | 23186163 | |
| 203 | Phosphorylation | TFLLVSGSLASVLIS HHHHHHCCHHHHHHH | 17.16 | - | |
| 206 | Phosphorylation | LVSGSLASVLISFVA HHHCCHHHHHHHHHH | 23.81 | - | |
| 228 | N-linked_Glycosylation | LTPRPGPNGSSLPPR CCCCCCCCCCCCCCC | 69.74 | UniProtKB CARBOHYD | |
| 231 | Phosphorylation | RPGPNGSSLPPRFGH CCCCCCCCCCCCCCC | 46.42 | 24719451 | |
| 243 | N-linked_Glycosylation | FGHFTGFNSSTLKDN CCCCCCCCCCHHCCC | 36.07 | UniProtKB CARBOHYD | |
| 297 (in isoform 2) | Ubiquitination | - | 16.46 | 21890473 | |
| 386 (in isoform 3) | Ubiquitination | - | 41.95 | 21890473 | |
| 386 | Ubiquitination | GVILAPAKVVSRGGN CEEEEEEEEECCCCC | 41.95 | 21890473 | |
| 386 (in isoform 1) | Ubiquitination | - | 41.95 | 21890473 | |
| 386 | Ubiquitination | GVILAPAKVVSRGGN CEEEEEEEEECCCCC | 41.95 | 21890473 | |
| 601 | Phosphorylation | VKAFVDLTLSPSVRQ HHHHHEEECCHHHHH | 22.26 | 21406692 | |
| 603 | Phosphorylation | AFVDLTLSPSVRQGA HHHEEECCHHHHHHH | 15.19 | 21406692 | |
| 605 | Phosphorylation | VDLTLSPSVRQGAQH HEEECCHHHHHHHHH | 26.93 | 21406692 | |
| 623 (in isoform 1) | Ubiquitination | - | 38.09 | 21890473 | |
| 623 | Ubiquitination | ISGLGGMKPNTLVLG HHCCCCCCCCEEEEE | 38.09 | 2190698 | |
| 658 | Phosphorylation | ADSTREGSSPALSTL CCCCCCCCCCCHHHC | 28.53 | 27486199 | |
| 659 | Phosphorylation | DSTREGSSPALSTLF CCCCCCCCCCHHHCC | 25.67 | 27486199 | |
| 663 | Phosphorylation | EGSSPALSTLFPPPR CCCCCCHHHCCCCCC | 25.77 | 27486199 | |
| 664 | Phosphorylation | GSSPALSTLFPPPRA CCCCCHHHCCCCCCC | 33.01 | 27486199 | |
| 674 | Phosphorylation | PPPRAPGSPRALNPQ CCCCCCCCCCCCCHH | 15.34 | 20860994 | |
| 703 | Phosphorylation | NVVLARASGALPPER CCEEHHCCCCCCHHH | 21.03 | 21406692 | |
| 740 | Phosphorylation | RPRGGPGYVDVCGLF CCCCCCCHHHHHHHH | 9.16 | - | |
| 753 | Phosphorylation | LFLLQMATILGMVPA HHHHHHHHHHCCCHH | 16.05 | - | |
| 763 | Phosphorylation | GMVPAWHSARLRIFL CCCHHHHHHHEEEEE | 12.37 | - | |
| 900 | Phosphorylation | LTRDLGPTLLVHGVT HHHHHCCEEEEECCC | 30.81 | 25348772 | |
| 907 | Phosphorylation | TLLVHGVTPVTCTDL EEEEECCCCCCCCCC | 19.34 | 25348772 | |
| 910 | Phosphorylation | VHGVTPVTCTDL--- EECCCCCCCCCC--- | 15.76 | 25348772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S12A9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S12A9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S12A9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of S12A9_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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