dbPTM

F189B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F189B_HUMAN
UniProt AC	P81408
Protein Name	Protein FAM189B
Gene Name	FAM189B
Organism	Homo sapiens (Human).
Sequence Length	668
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MMPSPSDSSRSLTSRPSTRGLTHLRLHRPWLQALLTLGLVQVLLGILVVTFSMVASSVTTTESIKRSCPSWAGFSLAFSGVVGIVSWKRPFTLVISFFSLLSVLCVMLSMAGSVLSCKNAQLARDFQQCSLEGKVCVCCPSVPLLRPCPESGQELKVAPNSTCDEARGALKNLLFSVCGLTICAAIICTLSAIVCCIQIFSLDLVHTLAPERSVSGPLGPLGCTSPPPAPLLHTMLDLEEFVPPVPPPPYYPPEYTCSSETDAQSITYNGSMDSPVPLYPTDCPPSYEAVMGLRGDSQATLFDPQLHDGSCICERVASIVDVSMDSGSLVLSAIGDLPGGSSPSEDSCLLELQGSVRSVDYVLFRSIQRSRAGYCLSLDCGLRGPFEESPLPRRPPRAARSYSCSAPEAPPPLGAPTAARSCHRLEGWPPWVGPCFPELRRRVPRGGGRPAAAPPTRAPTRRFSDSSGSLTPPGHRPPHPASPPPLLLPRSHSDPGITTSSDTADFRDLYTKVLEEEAASVSSADTGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRKAPDPSGTGAHGHKQVPRSLWGRPGRESLHLRSCGDLSSSSSLRRLLSGRRLERGTRPHSLSLNGGSRETGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	SPSDSSRSLTSRPST CCCCCCCCCCCCCCC	37.64	27251275
17	Phosphorylation	RSLTSRPSTRGLTHL CCCCCCCCCCCCCCH	29.62	24719451
160	N-linked_Glycosylation	QELKVAPNSTCDEAR CCEEECCCCCHHHHH	39.97	UniProtKB CARBOHYD
281	O-linked_Glycosylation	SPVPLYPTDCPPSYE CCCCCCCCCCCCCHH	36.36	OGP
297	Phosphorylation	VMGLRGDSQATLFDP HHCCCCCCCCEECCC	25.25	25850435
300	Phosphorylation	LRGDSQATLFDPQLH CCCCCCCEECCCCCC	21.96	25850435
310	Phosphorylation	DPQLHDGSCICERVA CCCCCCCCCHHHCHH	13.33	28555341
358	Phosphorylation	ELQGSVRSVDYVLFR HHCCCCCEECEEEEE	19.72	30266825
361	Phosphorylation	GSVRSVDYVLFRSIQ CCCCEECEEEEEHHH	9.26	23917254
377	Phosphorylation	SRAGYCLSLDCGLRG CCCCEEEEECCCCCC	20.71	26471730
389	Phosphorylation	LRGPFEESPLPRRPP CCCCCCCCCCCCCCC	25.25	23401153
456	Phosphorylation	RPAAAPPTRAPTRRF CCCCCCCCCCCCCCC	38.10	20393185
464	Phosphorylation	RAPTRRFSDSSGSLT CCCCCCCCCCCCCCC	34.47	28348404
466	Phosphorylation	PTRRFSDSSGSLTPP CCCCCCCCCCCCCCC	35.09	28348404
467	Phosphorylation	TRRFSDSSGSLTPPG CCCCCCCCCCCCCCC	37.07	28348404
469	Phosphorylation	RFSDSSGSLTPPGHR CCCCCCCCCCCCCCC	30.90	28348404
471	Phosphorylation	SDSSGSLTPPGHRPP CCCCCCCCCCCCCCC	29.18	28348404
482	Phosphorylation	HRPPHPASPPPLLLP CCCCCCCCCCCCCCC	42.25	26425664
483	Ubiquitination	RPPHPASPPPLLLPR CCCCCCCCCCCCCCC	36.31	21890473
491	Phosphorylation	PPLLLPRSHSDPGIT CCCCCCCCCCCCCCC	25.96	29255136
493	Phosphorylation	LLLPRSHSDPGITTS CCCCCCCCCCCCCCC	46.90	23401153
494	Phosphorylation	LLPRSHSDPGITTSS CCCCCCCCCCCCCCC	39.77	18669648
498	Phosphorylation	SHSDPGITTSSDTAD CCCCCCCCCCCCCHH	26.92	28450419
499	Phosphorylation	HSDPGITTSSDTADF CCCCCCCCCCCCHHH	25.06	23927012
500	Phosphorylation	SDPGITTSSDTADFR CCCCCCCCCCCHHHH	19.98	23927012
501	Phosphorylation	DPGITTSSDTADFRD CCCCCCCCCCHHHHH	36.57	30576142
503	Phosphorylation	GITTSSDTADFRDLY CCCCCCCCHHHHHHH	30.03	23927012
544	Sumoylation	LARCPSPKLLRARSA HHCCCCHHHHHHCCC	65.57	-
550	Phosphorylation	PKLLRARSAEKRRPV HHHHHHCCCCCCCCC	39.53	29514088
561	Ubiquitination	RRPVPTFQKVPLPSG CCCCCCCCCCCCCCC	48.60	21890473
574	Phosphorylation	SGPAPAHSLGDLKGS CCCCCCCCCCCCCCC	35.83	25159151
579	Ubiquitination	AHSLGDLKGSWPGRG CCCCCCCCCCCCCCC	56.49	21890473
579	Ubiquitination	AHSLGDLKGSWPGRG CCCCCCCCCCCCCCC	56.49	21890473
580	Ubiquitination	HSLGDLKGSWPGRGL CCCCCCCCCCCCCCH	42.09	21890473
629	Phosphorylation	RESLHLRSCGDLSSS CCCEEECCCCCCCCC	28.89	28348404
644	Phosphorylation	SSLRRLLSGRRLERG HHHHHHHHCCCCCCC	34.54	-
652	Phosphorylation	GRRLERGTRPHSLSL CCCCCCCCCCCEECC	47.45	29449344
656	Phosphorylation	ERGTRPHSLSLNGGS CCCCCCCEECCCCCC	23.49	29449344
658	Phosphorylation	GTRPHSLSLNGGSRE CCCCCEECCCCCCCC	23.85	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F189B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of F189B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F189B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7C_HUMAN	HSPA8	physical	26186194
WWOX_HUMAN	WWOX	physical	26186194
NEDD4_HUMAN	NEDD4	physical	26186194
ITCH_HUMAN	ITCH	physical	26186194
NED4L_HUMAN	NEDD4L	physical	26186194
WWP1_HUMAN	WWP1	physical	26186194
PPAL_HUMAN	ACP2	physical	26186194
AN13A_HUMAN	ANKRD13A	physical	26186194
AN13D_HUMAN	ANKRD13D	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194
HECW2_HUMAN	HECW2	physical	26186194
TPM2_HUMAN	TPM2	physical	26186194
CFA74_HUMAN	CFAP74	physical	26186194
CYHR1_HUMAN	CYHR1	physical	26186194
HBB_HUMAN	HBB	physical	26186194
YAP1_HUMAN	YAP1	physical	26186194
SETD7_HUMAN	SETD7	physical	26186194
TSN3_HUMAN	TSPAN3	physical	26186194
RHBD3_HUMAN	RHBDD3	physical	26186194
BT2A2_HUMAN	BTN2A2	physical	26186194
WWOX_HUMAN	WWOX	physical	28514442
HECW1_HUMAN	HECW1	physical	28514442
HECW2_HUMAN	HECW2	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442
CYHR1_HUMAN	CYHR1	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
RN111_HUMAN	RNF111	physical	28514442
SMO_HUMAN	SMO	physical	28514442
ABCD4_HUMAN	ABCD4	physical	28514442
AN13D_HUMAN	ANKRD13D	physical	28514442
ITCH_HUMAN	ITCH	physical	28514442
UBXN7_HUMAN	UBXN7	physical	28514442
CAN15_HUMAN	CAPN15	physical	28514442
HERC4_HUMAN	HERC4	physical	28514442
WWP1_HUMAN	WWP1	physical	28514442
ST7L_HUMAN	ST7L	physical	28514442
AGRL1_HUMAN	LPHN1	physical	28514442
CUED1_HUMAN	CUEDC1	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
AN13A_HUMAN	ANKRD13A	physical	28514442
HERC3_HUMAN	HERC3	physical	28514442
ABRX2_HUMAN	FAM175B	physical	28514442
FND3B_HUMAN	FNDC3B	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
KCNT2_HUMAN	KCNT2	physical	28514442
BAG3_HUMAN	BAG3	physical	28514442
RABX5_HUMAN	RABGEF1	physical	28514442
EDA_HUMAN	EDA	physical	28514442
RHBD3_HUMAN	RHBDD3	physical	28514442
PCX3_HUMAN	PCNXL3	physical	28514442
SPIT2_HUMAN	SPINT2	physical	28514442
BABA1_HUMAN	BABAM1	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
BABA2_HUMAN	BRE	physical	28514442
NPL4_HUMAN	NPLOC4	physical	28514442
S27A3_HUMAN	SLC27A3	physical	28514442
TRI32_HUMAN	TRIM32	physical	28514442
GP1BB_HUMAN	GP1BB	physical	28514442
BT2A2_HUMAN	BTN2A2	physical	28514442
PDE3B_HUMAN	PDE3B	physical	28514442
AMFR_HUMAN	AMFR	physical	28514442
S12A4_HUMAN	SLC12A4	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
UTRO_HUMAN	UTRN	physical	28514442
CNEP1_HUMAN	CTDNEP1	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
S47A1_HUMAN	SLC47A1	physical	28514442
T179B_HUMAN	TMEM179B	physical	28514442
KLRG2_HUMAN	KLRG2	physical	28514442
NSMA_HUMAN	SMPD2	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
RHBL4_HUMAN	RHBDD1	physical	28514442
UFD1_HUMAN	UFD1L	physical	28514442
ST7_HUMAN	ST7	physical	28514442
CIP4_HUMAN	TRIP10	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
TERA_HUMAN	VCP	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F189B_HUMAN

Related Literatures of Post-Translational Modification