CAN15_HUMAN - dbPTM
CAN15_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAN15_HUMAN
UniProt AC O75808
Protein Name Calpain-15
Gene Name CAPN15
Organism Homo sapiens (Human).
Sequence Length 1086
Subcellular Localization
Protein Description
Protein Sequence MATVGEWSCVRCTFLNPAGQRQCSICEAPRHKPDLNHILRLSVEEQKWPCARCTFRNFLGKEACEVCGFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEEEATEGGTSRVEAGSSTSGSDIIDLAGDTVRYTPASPSSPDFTTWSCAKCTLRNPTVAPRCSACGCSKLHGFQEHGEPPTHCPDCGADKPSPCGRSCGRVSSAQKAARVLPERPGQWACPACTLLNALRAKHCAACHTPQLLVAQRRGAAPLRRRESMHVEQRRQTDEGEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYSILDVRDVQGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSDWQEARVQGCFPSSASAPVGVTALTVLERASLEFALFQEGSRRSDAVDSHLLDLCILVFRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAFNHWGPPLPGTPAPQASSPSAGVPRASPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLTESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKAYLHVQCDCTDSFNVVSTRGSLRTQDSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASKGTHSPPLTPEVAGLHGPRPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationEWSCVRCTFLNPAGQ
CEEEEEEEEECCCCC		22.1622817900
24PhosphorylationPAGQRQCSICEAPRH
CCCCCCCCCCCCCCC		23.1828857561
32UbiquitinationICEAPRHKPDLNHIL
CCCCCCCCCCHHHHH		41.3233845483
42PhosphorylationLNHILRLSVEEQKWP
HHHHHHHCHHHCCCC		22.5021815630
47UbiquitinationRLSVEEQKWPCARCT
HHCHHHCCCCCCCCH		57.28-
100PhosphorylationILGEPKGSCQEEAGP
CCCCCCCCCCCCCCC		20.8227130503
116PhosphorylationRTAGLVATEPARGQC
CEEEEEECCCCCCCC		34.7127130503
126AcetylationARGQCEDKDEEEKEE
CCCCCCCCCHHHHHH		44.7526051181
126UbiquitinationARGQCEDKDEEEKEE
CCCCCCCCCHHHHHH		44.7521963094
131UbiquitinationEDKDEEEKEEQEEEE
CCCCHHHHHHHHHHH		70.5921963094
153PhosphorylationGWACPRCTLHNTPVA
CEECCCCCCCCCCCC		32.1222210691
157PhosphorylationPRCTLHNTPVASSCS
CCCCCCCCCCCCCCC		14.3722210691
164PhosphorylationTPVASSCSVCGGPRR
CCCCCCCCCCCCCCC		23.5322210691
173PhosphorylationCGGPRRLSLPRIPPE
CCCCCCCCCCCCCHH		34.2224719451
194UbiquitinationVVAPAGFHVVPAAPP
EECCCCCEEECCCCC		20.8121963094
199UbiquitinationGFHVVPAAPPPGLPG
CCEEECCCCCCCCCC		15.8621963094
266PhosphorylationVPEAAQPSPSAGCRG
CCCCCCCCCCCCCCC		21.2921815630
291PhosphorylationSRLAELLSGKRLSVL
HHHHHHHCCCCEEEE		55.69-
293 (in isoform 2)Ubiquitination-46.9521906983
293AcetylationLAELLSGKRLSVLEE
HHHHHCCCCEEEEEE		46.9525953088
293 (in isoform 1)Ubiquitination-46.9521890473
293UbiquitinationLAELLSGKRLSVLEE
HHHHHCCCCEEEEEE		46.9521906983
296PhosphorylationLLSGKRLSVLEEEAT
HHCCCCEEEEEEHHH		28.7930266825
303PhosphorylationSVLEEEATEGGTSRV
EEEEEHHHCCCCCCE		38.1423403867
307PhosphorylationEEATEGGTSRVEAGS
EHHHCCCCCCEEECC		24.9823403867
308PhosphorylationEATEGGTSRVEAGSS
HHHCCCCCCEEECCC		37.2923403867
317PhosphorylationVEAGSSTSGSDIIDL
EEECCCCCCCCEEEC		37.9428348404
319PhosphorylationAGSSTSGSDIIDLAG
ECCCCCCCCEEECCC		25.9628348404
331PhosphorylationLAGDTVRYTPASPSS
CCCCEEEECCCCCCC		16.8530576142
332PhosphorylationAGDTVRYTPASPSSP
CCCEEEECCCCCCCC		11.2123401153
335PhosphorylationTVRYTPASPSSPDFT
EEEECCCCCCCCCCC		26.9025159151
337PhosphorylationRYTPASPSSPDFTTW
EECCCCCCCCCCCCC		52.5925159151
338PhosphorylationYTPASPSSPDFTTWS
ECCCCCCCCCCCCCE		31.6925159151
342PhosphorylationSPSSPDFTTWSCAKC
CCCCCCCCCCEEECC		34.4328450419
343PhosphorylationPSSPDFTTWSCAKCT
CCCCCCCCCEEECCC		18.5128450419
345PhosphorylationSPDFTTWSCAKCTLR
CCCCCCCEEECCCCC		11.3427080861
348UbiquitinationFTTWSCAKCTLRNPT
CCCCEEECCCCCCCC		31.8932015554
361UbiquitinationPTVAPRCSACGCSKL
CCCCCCCCCCCCCCC		28.0721963094
390PhosphorylationDCGADKPSPCGRSCG
CCCCCCCCCCCCCCC		38.2628555341
404AcetylationGRVSSAQKAARVLPE
CCCCHHHHHHHHCCC		43.6718586551
404UbiquitinationGRVSSAQKAARVLPE
CCCCHHHHHHHHCCC		43.6722053931
430UbiquitinationLLNALRAKHCAACHT
HHHHHHHHHHHHCCC		32.55-
437PhosphorylationKHCAACHTPQLLVAQ
HHHHHCCCHHHHHHH		16.7728555341
456PhosphorylationAPLRRRESMHVEQRR
CCCHHHHHHCHHHHH		16.6328857561
471UbiquitinationQTDEGEAKALWENIV
CCCHHHHHHHHHHHH		39.4421963094
472UbiquitinationTDEGEAKALWENIVA
CCHHHHHHHHHHHHH		25.5922053931
539UbiquitinationTWSVFHTLRPSDILQ
HHHEEECCCHHHHHH		5.9421963094
618UbiquitinationLFSQAQRKQLWVALI
ECCHHHHHHHHHHHH		37.35-
627UbiquitinationLWVALIEKALAKLHG
HHHHHHHHHHHHHHC		41.53-
631UbiquitinationLIEKALAKLHGSYFA
HHHHHHHHHHCHHHH		41.7029967540
681UbiquitinationDTDLIWAKMLSSKEA
CHHHHHHHHCCCCCC		25.9421906983
681 (in isoform 1)Ubiquitination-25.9421890473
686UbiquitinationWAKMLSSKEAGFLMG
HHHHCCCCCCCEECC		48.4821963094
702UbiquitinationSCGGGNMKVDDSAYE
CCCCCCCCCCHHHHH		46.65-
706PhosphorylationGNMKVDDSAYESLGL
CCCCCCHHHHHHCCC		28.4323312004
708PhosphorylationMKVDDSAYESLGLRP
CCCCHHHHHHCCCCC		15.2523312004
710PhosphorylationVDDSAYESLGLRPRH
CCHHHHHHCCCCCCC		18.3023312004
720PhosphorylationLRPRHAYSILDVRDV
CCCCCEEEEEEEECC		19.9128857561
749UbiquitinationFSWNGSWSDEWPHWP
CCCCCCCCCCCCCCC		27.6121963094
754UbiquitinationSWSDEWPHWPGHLRG
CCCCCCCCCCCCCCC		44.4221963094
791UbiquitinationFDSVDICKVHSDWQE
ECCCCEEEECCCHHH		43.2321963094
808PhosphorylationVQGCFPSSASAPVGV
HCCCCCCCCCCCCCC		26.8722468782
856PhosphorylationCILVFRATFGSGGHL
HHHHHHHCCCCCCCC		25.0323312004
859UbiquitinationVFRATFGSGGHLSLG
HHHHCCCCCCCCHHH		37.0921963094
859PhosphorylationVFRATFGSGGHLSLG
HHHHCCCCCCCCHHH		37.0923312004
1053UbiquitinationTHRLAHRKAAQAFLS
HHHHHHHHHHHHHHH		37.90-
1066 (in isoform 1)Ubiquitination-66.4221890473
1066UbiquitinationLSDWTASKGTHSPPL
HHHHHHCCCCCCCCC		66.4221963094
1068PhosphorylationDWTASKGTHSPPLTP
HHHHCCCCCCCCCCH		23.9429255136
1070PhosphorylationTASKGTHSPPLTPEV
HHCCCCCCCCCCHHH		28.2229255136
1074UbiquitinationGTHSPPLTPEVAGLH
CCCCCCCCHHHCCCC		24.1521890473
1074PhosphorylationGTHSPPLTPEVAGLH
CCCCCCCCHHHCCCC		24.1528450419
1134Ubiquitination-------------------------------------------------------
-------------------------------------------------------		21890473
1142Ubiquitination---------------------------------------------------------------
---------------------------------------------------------------		21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAN15_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAN15_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAN15_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CAN15_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAN15_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory