CFA74_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFA74_HUMAN
• UniProt AC: Q9C0B2
• Protein Name: Cilia- and flagella-associated protein 74 {ECO:0000305}
• Gene Name: CFAP74 {ECO:0000312|HGNC:HGNC:29368}
• Organism: Homo sapiens (Human).
• Sequence Length: 1584
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme .
• Protein Description: As part of the central apparatus of the cilium axoneme may play a role in cilium movement..
• Protein Sequence: MEDDGSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAEDDVDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGELRACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTEAVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVERNRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHEYMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRHLVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTLRDKTWNYISDFCKKTTVPTNTYTLDYEAAAGPGPSRLLEVVSSELIQGDPGASSEEETLAEPEISGLWNEDYKPYQVPKEDVDRKPVGGTKMDKDILERTVERLRSRVVHKQVVWGREFQGRPFNSKPELLHFQDFDIGKVYKKKITLVNTTYTINYCKLVGVEEHLRDFIHVDFDPPGPLSAGMSCEVLVTFKPMINKDLEGNISFLAQTGEFSVPLKCSTKKCSLSLDKELIDFGSYVVGETTSRTITLTNVGGLGTTFKFLPASEPCEMDDSQSALKLSSLLTYEDKSLYDKAATSFSEQQLEGTESSQADMQSRKELEKLDKEQEEEQPAEPERLTTVIPPSEEQTEITLGEVTEGEIGPFSSIKVPIVFTPVVPGDVQARFKVTFKNPQCPTLHFRVVGVAIDVPVWVPKPSVDLKICMYDRLYQDSVLVHTRSKAALRLKFEVCKELRAHLELLPKTGYIQAQSSYSVQLKFLPRHSLPEDAGRYFDKETRVLEAPMTIWVADQNKPVGFTVHAIVTTSDLELSPSEVDFGYCTIYEAIRTEISLHNHSLLPQEFGFVRLPKFVDVQPNDGFGTILPLETLQFCVIFQPTKAEEHRFQLTCKSEINRCFKLSCRAVGVHPPLELSHYQIKFAATALYDTSVATVYVINSHLSMSSPTHSKPRIGSEDASPMGPTSFEFLLPPDSPITISPSVGTVWPGKRCLVQVAFRPVLPEKLIRQEALPLLNKEMETKSFRKNMAPQRKDLHGLSFSVLRAQNRDKLFKVSVPHVLEMRKRELRPSSDEYQAARATLLRAFQAKFDTFVVPCVVASGDIKDRKGSEPLSFSPHNTLYLELWCPTVAPSVVVTSHKGKTIFNFGDVAVGHRSIKKISIQNVSPEDLALDFSLLNPNGPFVLLNHSSLLRAGGTQVLVLSFSPHESILAQETLDIITKRGTLTLTLMGTGVASMITCSIEGSVLNMGYVIAGESVSSGFKLQNNSLLPIKFSMHLDSLSSTRGRGQQQLPQFLSSPSQRTEVVGTQNLNGQSVFSVAPVKGVMDPGKTQDFTVTFSPDHESLYFSDKLQVVLFEKKISHQILLKGAACQHMMFVEGGDPLDVPVESLTAIPVFDPRHREEAEELRPILVTLDYIQFDTDTPAPPATRELQVGCIRTTQPSPKKPDHPLMVSALLQLRGDVKETYKVIFVAQVLTGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	FHLRQNLSALDKMHE HHHHHHHHHHHHHHH		27251275
257	Acetylation	KVAVRFLKASLGRIR HHHHHHHHHHHHHHH		26210075
491	Phosphorylation	DKDILERTVERLRSR CHHHHHHHHHHHHHH		24670416
497	O-linked_Glycosylation	RTVERLRSRVVHKQV HHHHHHHHHHCCCEE		30379171
531	Acetylation	FQDFDIGKVYKKKIT CCCCCCCCEEECEEE		20167786
535	Acetylation	DIGKVYKKKITLVNT CCCCEEECEEEEEEC		20167786
536	Acetylation	IGKVYKKKITLVNTT CCCEEECEEEEEECE		20167786
629	Phosphorylation	KELIDFGSYVVGETT HHHHHCCCEEEEECC		22468782
630	Phosphorylation	ELIDFGSYVVGETTS HHHHCCCEEEEECCC		22468782
636	Phosphorylation	SYVVGETTSRTITLT CEEEEECCCCEEEEE		22468782
658	Phosphorylation	TFKFLPASEPCEMDD EEEECCCCCCCCCCC		25693802
666	Phosphorylation	EPCEMDDSQSALKLS CCCCCCCHHHHHHHH		30622161
668	Phosphorylation	CEMDDSQSALKLSSL CCCCCHHHHHHHHHH		30622161
673	Phosphorylation	SQSALKLSSLLTYED HHHHHHHHHHCCCCC		-
677	Phosphorylation	LKLSSLLTYEDKSLY HHHHHHCCCCCHHHH		-
684	Phosphorylation	TYEDKSLYDKAATSF CCCCHHHHHHHCCCC		-
1295	Phosphorylation	FVLLNHSSLLRAGGT EEEECHHHHHHCCCE		24719451
1373	Phosphorylation	GFKLQNNSLLPIKFS CEEECCCCEECEEEE		29978859
1402	Phosphorylation	QQLPQFLSSPSQRTE HCHHHHHCCHHHCEE		26699800
1403	Phosphorylation	QLPQFLSSPSQRTEV CHHHHHCCHHHCEEE		26699800
1449	Phosphorylation	TFSPDHESLYFSDKL EECCCCCCEECCCCE		24719451
1466	Phosphorylation	VLFEKKISHQILLKG EEEECCCCHHHHHCC		24505115

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFA74_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFA74_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFA74_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CFA74_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.