| UniProt ID | NSMA_HUMAN | |
|---|---|---|
| UniProt AC | O60906 | |
| Protein Name | Sphingomyelin phosphodiesterase 2 | |
| Gene Name | SMPD2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 423 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.. | |
| Protein Sequence | MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Ubiquitination | YLSKHRADRMRRLGD HHCHHHHHHHHHHHH | 44.88 | 22817900 | |
| 103 | Ubiquitination | HIYTLNGYPYMIHHG HHHHHCCCCEEEECC | 7.07 | 22817900 | |
| 208 | Ubiquitination | YLETRDFKGSEEGNT EEECCCCCCCCCCCC | 66.86 | 22817900 | |
| 254 | Phosphorylation | GFYISCKSFETTTGF CEEEEEECEEECCCC | 32.42 | 22210691 | |
| 257 | Phosphorylation | ISCKSFETTTGFDPH EEEECEEECCCCCCC | 27.87 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NSMA_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NSMA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NSMA_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MTHR_HUMAN | MTHFR | physical | 26186194 | |
| APC10_HUMAN | ANAPC10 | physical | 26186194 | |
| MTHR_HUMAN | MTHFR | physical | 28514442 | |
| APC10_HUMAN | ANAPC10 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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