dbPTM

SPIT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPIT2_HUMAN
UniProt AC	O43291
Protein Name	Kunitz-type protease inhibitor 2
Gene Name	SPINT2
Organism	Homo sapiens (Human).
Sequence Length	252
Subcellular Localization	Membrane Single-pass type I membrane protein .
Protein Description	Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa..
Protein Sequence	MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	AFLALLGSLLLSGVL HHHHHHHHHHHHHHH	18.80	24719451
33	Phosphorylation	LAADRERSIHDFCLV HHHHHCCCHHHHHHH	21.37	28961369
57	N-linked_Glycosylation	SMPRWWYNVTDGSCQ CCCCEEEEECCCCEE	19.25	UniProtKB CARBOHYD
81	Acetylation	NSNNYLTKEECLKKC CCCCCCCHHHHHHHH	49.25	7479639
87	Ubiquitination	TKEECLKKCATVTEN CHHHHHHHHCCCCCC	19.02	-
92	Phosphorylation	LKKCATVTENATGDL HHHHCCCCCCCCCCH	21.11	22210691
94	N-linked_Glycosylation	KCATVTENATGDLAT HHCCCCCCCCCCHHH	33.18	UniProtKB CARBOHYD
101	Phosphorylation	NATGDLATSRNAADS CCCCCHHHCCCCCCC	35.20	22210691
101	O-linked_Glycosylation	NATGDLATSRNAADS CCCCCHHHCCCCCCC	35.20	55832809
102	Phosphorylation	ATGDLATSRNAADSS CCCCHHHCCCCCCCC	20.24	22210691
102	O-linked_Glycosylation	ATGDLATSRNAADSS CCCCHHHCCCCCCCC	20.24	55832813
108	O-linked_Glycosylation	TSRNAADSSVPSAPR HCCCCCCCCCCCCCC	28.63	55828365
109	O-linked_Glycosylation	SRNAADSSVPSAPRR CCCCCCCCCCCCCCC	38.30	55828371
112	O-linked_Glycosylation	AADSSVPSAPRRQDS CCCCCCCCCCCCCCC	49.07	55828377
119	Phosphorylation	SAPRRQDSEDHSSDM CCCCCCCCCCCCCCC	36.26	28348404
123	Phosphorylation	RQDSEDHSSDMFNYE CCCCCCCCCCCCCHH	40.11	28348404
124	Phosphorylation	QDSEDHSSDMFNYEE CCCCCCCCCCCCHHH	29.67	28348404
134	O-linked_Glycosylation	FNYEEYCTANAVTGP CCHHHHHHHCCCCCC	23.26	OGP
150	Phosphorylation	RASFPRWYFDVERNS CCCCCCEEEEECCCC	7.38	-
163	Phosphorylation	NSCNNFIYGGCRGNK CCCCCCCCCCCCCCC	11.88	-
185	Ubiquitination	ACMLRCFRQQENPPL HHHHHHHHCCCCCCC	40.68	21890473
190	Ubiquitination	CFRQQENPPLPLGSK HHHCCCCCCCCCCCH	30.93	21890473
234	Phosphorylation	NQERALRTVWSSGDD HHHHHHHHHHCCCCC	27.46	27251275
237	Phosphorylation	RALRTVWSSGDDKEQ HHHHHHHCCCCCHHH	21.80	26657352
238	Phosphorylation	ALRTVWSSGDDKEQL HHHHHHCCCCCHHHH	30.45	29496963
242	2-Hydroxyisobutyrylation	VWSSGDDKEQLVKNT HHCCCCCHHHHHHHE	52.69	-
242	Ubiquitination	VWSSGDDKEQLVKNT HHCCCCCHHHHHHHE	52.69	21890473
247	Ubiquitination	DDKEQLVKNTYVL-- CCHHHHHHHEEEC--	52.76	21890473
250	Phosphorylation	EQLVKNTYVL----- HHHHHHEEEC-----	14.78	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPIT2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPIT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPIT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GCP2_HUMAN	TUBGCP2	physical	26186194
LSR_HUMAN	LSR	physical	26186194
AT12A_HUMAN	ATP12A	physical	26186194
LIN54_HUMAN	LIN54	physical	26186194
TBC9B_HUMAN	TBC1D9B	physical	26186194
TBC15_HUMAN	TBC1D15	physical	26186194
AT2A3_HUMAN	ATP2A3	physical	26186194
IPIL1_HUMAN	ITPRIPL1	physical	26186194
FND3A_HUMAN	FNDC3A	physical	26186194
ZN696_HUMAN	ZNF696	physical	26186194
OCRL_HUMAN	OCRL	physical	26186194
ABCA3_HUMAN	ABCA3	physical	26186194
RS7_HUMAN	RPS7	physical	26186194
TM214_HUMAN	TMEM214	physical	26186194
CNDD3_HUMAN	NCAPD3	physical	26186194
SRBP2_HUMAN	SREBF2	physical	26186194
THA11_HUMAN	THAP11	physical	26186194
IQCB1_HUMAN	IQCB1	physical	26186194
TSC2_HUMAN	TSC2	physical	26186194
WDR44_HUMAN	WDR44	physical	26186194
MAN1_HUMAN	LEMD3	physical	26186194
P121A_HUMAN	POM121	physical	26186194
UBR3_HUMAN	UBR3	physical	26186194
TBL2_HUMAN	TBL2	physical	26186194
AT8B2_HUMAN	ATP8B2	physical	26186194
DIP2A_HUMAN	DIP2A	physical	26186194
NFRKB_HUMAN	NFRKB	physical	26186194
SAC1_HUMAN	SACM1L	physical	26186194
ZDH13_HUMAN	ZDHHC13	physical	26186194
RETST_HUMAN	RETSAT	physical	26186194
DHRS7_HUMAN	DHRS7	physical	26186194
SPTC2_HUMAN	SPTLC2	physical	26186194
BIG1_HUMAN	ARFGEF1	physical	26186194
CCZ1B_HUMAN	CCZ1	physical	26186194
CCZ1_HUMAN	CCZ1	physical	26186194
ACV1B_HUMAN	ACVR1B	physical	26186194
CP51A_HUMAN	CYP51A1	physical	26186194
PRR14_HUMAN	PRR14	physical	26186194
LRIF1_HUMAN	LRIF1	physical	26186194
MA7D3_HUMAN	MAP7D3	physical	26186194
CDC20_HUMAN	CDC20	physical	26186194
TYW1_HUMAN	TYW1	physical	26186194
CT024_HUMAN	C20orf24	physical	26186194
SMC2_HUMAN	SMC2	physical	26186194
DJC16_HUMAN	DNAJC16	physical	26186194
MSPD2_HUMAN	MOSPD2	physical	26186194
BAG3_HUMAN	BAG3	physical	26186194
KIF14_HUMAN	KIF14	physical	26186194
HYEP_HUMAN	EPHX1	physical	26186194
TAF6L_HUMAN	TAF6L	physical	26186194
ALG5_HUMAN	ALG5	physical	26186194
NOP9_HUMAN	NOP9	physical	26186194
OSBL8_HUMAN	OSBPL8	physical	26186194
NGBR_HUMAN	NUS1	physical	26186194
S35F5_HUMAN	SLC35F5	physical	26186194
TX264_HUMAN	TEX264	physical	26186194
CKAP5_HUMAN	CKAP5	physical	26186194
TMUB1_HUMAN	TMUB1	physical	26186194
DPOE2_HUMAN	POLE2	physical	26186194
HMDH_HUMAN	HMGCR	physical	26186194
UPK3L_HUMAN	UPK3BL	physical	26186194
FND3B_HUMAN	FNDC3B	physical	26186194
VRK2_HUMAN	VRK2	physical	26186194
MZT2B_HUMAN	MZT2B	physical	26186194
S39AA_HUMAN	SLC39A10	physical	26186194
SC22A_HUMAN	SEC22A	physical	26186194
ELF2_HUMAN	ELF2	physical	26186194
S39A6_HUMAN	SLC39A6	physical	26186194
CA112_HUMAN	C1orf112	physical	26186194
UBP33_HUMAN	USP33	physical	26186194
NDC1_HUMAN	NDC1	physical	26186194
ZNT7_HUMAN	SLC30A7	physical	26186194
LMF1_HUMAN	LMF1	physical	26186194
GOGA5_HUMAN	GOLGA5	physical	26186194
GTPB3_HUMAN	GTPBP3	physical	26186194
DGLB_HUMAN	DAGLB	physical	26186194
VANG2_HUMAN	VANGL2	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
DPH1_HUMAN	DPH1	physical	26186194
FRMD5_HUMAN	FRMD5	physical	26186194
CHD8_HUMAN	CHD8	physical	26186194
P4K2B_HUMAN	PI4K2B	physical	26186194
S27A3_HUMAN	SLC27A3	physical	26186194
CKLF6_HUMAN	CMTM6	physical	26186194
EGFL7_HUMAN	EGFL7	physical	26186194
PMYT1_HUMAN	PKMYT1	physical	26186194
LRP10_HUMAN	LRP10	physical	26186194
CNTP1_HUMAN	CNTNAP1	physical	26186194
ZDH18_HUMAN	ZDHHC18	physical	26186194
CTU1_HUMAN	CTU1	physical	26186194
TIGD5_HUMAN	TIGD5	physical	26186194
KLH26_HUMAN	KLHL26	physical	26186194
LRP12_HUMAN	LRP12	physical	26186194
ASPH2_HUMAN	ASPHD2	physical	26186194
PRR14_HUMAN	PRR14	physical	28514442
ELF2_HUMAN	ELF2	physical	28514442
SREC2_HUMAN	SCARF2	physical	28514442
KIF14_HUMAN	KIF14	physical	28514442
LIN54_HUMAN	LIN54	physical	28514442
CNTP1_HUMAN	CNTNAP1	physical	28514442
NFRKB_HUMAN	NFRKB	physical	28514442
LRIF1_HUMAN	LRIF1	physical	28514442
PMYT1_HUMAN	PKMYT1	physical	28514442
FND3B_HUMAN	FNDC3B	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
TBC9B_HUMAN	TBC1D9B	physical	28514442
HGFA_HUMAN	HGFAC	physical	28514442
MSPD2_HUMAN	MOSPD2	physical	28514442
UBR3_HUMAN	UBR3	physical	28514442
HYEP_HUMAN	EPHX1	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
S39AA_HUMAN	SLC39A10	physical	28514442
S35F5_HUMAN	SLC35F5	physical	28514442
FRMD5_HUMAN	FRMD5	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
P121A_HUMAN	POM121	physical	28514442
RNF13_HUMAN	RNF13	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
RETST_HUMAN	RETSAT	physical	28514442
CA112_HUMAN	C1orf112	physical	28514442
MZT2B_HUMAN	MZT2B	physical	28514442
UPK3L_HUMAN	UPK3BL	physical	28514442
CKAP5_HUMAN	CKAP5	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
GTPB3_HUMAN	GTPBP3	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442
TIGD5_HUMAN	TIGD5	physical	28514442
DPH1_HUMAN	DPH1	physical	28514442
IQCB1_HUMAN	IQCB1	physical	28514442
ZN696_HUMAN	ZNF696	physical	28514442
LSR_HUMAN	LSR	physical	28514442
NOP9_HUMAN	NOP9	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
EGFL7_HUMAN	EGFL7	physical	28514442
THA11_HUMAN	THAP11	physical	28514442
VRK2_HUMAN	VRK2	physical	28514442
S27A3_HUMAN	SLC27A3	physical	28514442
CP51A_HUMAN	CYP51A1	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
AT8B2_HUMAN	ATP8B2	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
MARC1_HUMAN	MARC1	physical	28514442
SPTC2_HUMAN	SPTLC2	physical	28514442
CHD8_HUMAN	CHD8	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
TAF6L_HUMAN	TAF6L	physical	28514442
CT024_HUMAN	C20orf24	physical	28514442
S39A6_HUMAN	SLC39A6	physical	28514442
IPIL1_HUMAN	ITPRIPL1	physical	28514442
MA7D3_HUMAN	MAP7D3	physical	28514442
BAG3_HUMAN	BAG3	physical	28514442
ZDH13_HUMAN	ZDHHC13	physical	28514442
UBP33_HUMAN	USP33	physical	28514442
GPN3_HUMAN	GPN3	physical	28514442
TX264_HUMAN	TEX264	physical	28514442
CCZ1B_HUMAN	CCZ1	physical	28514442
CCZ1_HUMAN	CCZ1	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
P4K2B_HUMAN	PI4K2B	physical	28514442
AR6P6_HUMAN	ARL6IP6	physical	28514442

Drug and Disease Associations

Kegg Disease
H01174	Congenital diarrhea, including: Congenital chloride diarrhea (DIAR1); Microvillus inclusion disease
OMIM Disease
270420	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPIT2_HUMAN

Related Literatures of Post-Translational Modification