IPIL1_HUMAN - dbPTM
IPIL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IPIL1_HUMAN
UniProt AC Q6GPH6
Protein Name Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
Gene Name ITPRIPL1
Organism Homo sapiens (Human).
Sequence Length 555
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description
Protein Sequence MNVDAEASMAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRLLEMEFEERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQEGPLGWMLGNLWNTGLFCLFLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLTDFPSQEALDSFYKHYVQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLGIGAAFEKWGTLHETQKFDILVPIVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDPSAVLGKCSSSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVAHKYDFKLSLPPSTTSCKLRLDYRSGRFLSIHLVLGVQREDTLVYLVSQAPDQEQLTSVDWPESFVACEHLFLKLVGRFAPENTCHLKCLQIILSLRQHQSLPHGASRPILTSYHFKTALMHLLLRLPLTDWAHNMLSQRLQDILWFLGRGLQQRSLHHFLIGNNFLPLTIPIPKTFRNAEPVNLFQHLVLNPKAHSQAVEEFQNLLTQVKTLPHAPLAAAP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 2)Phosphorylation-40.1424043423
3 (in isoform 2)Phosphorylation-7.7224043423
5 (in isoform 2)Phosphorylation-15.2424043423
6 (in isoform 2)Phosphorylation-36.4924043423
7 (in isoform 2)Phosphorylation-13.3124043423
9 (in isoform 2)Phosphorylation-4.4424043423
10 (in isoform 2)Phosphorylation-7.9424043423
16 (in isoform 2)Phosphorylation-5.0924043423
21 (in isoform 2)Phosphorylation-7.8524043423
29 (in isoform 2)Phosphorylation-7.6824043423
38 (in isoform 2)Phosphorylation-3.5824043423
41PhosphorylationDLDTLARSRQLEKRM
CHHHHHHHHHHHHHH		20.83-
49PhosphorylationRQLEKRMSEEMRLLE
HHHHHHHHHHHHHHH		34.1427174698
63UbiquitinationEMEFEERKRAAEQRQ
HHHHHHHHHHHHHHH		50.0629967540
71UbiquitinationRAAEQRQKAENFWTG
HHHHHHHHHHHCCCC		60.9129967540
77PhosphorylationQKAENFWTGDTSSDQ
HHHHHCCCCCCCCCE		22.5019367720
79UbiquitinationAENFWTGDTSSDQLV
HHHCCCCCCCCCEEE		35.7229967540
81UbiquitinationNFWTGDTSSDQLVLG
HCCCCCCCCCEEEEC		36.3422817900
81UbiquitinationNFWTGDTSSDQLVLG
HCCCCCCCCCEEEEC		36.3421906983
81PhosphorylationNFWTGDTSSDQLVLG
HCCCCCCCCCEEEEC		36.3419367720
82UbiquitinationFWTGDTSSDQLVLGK
CCCCCCCCCEEEECC		31.3122817900
89 (in isoform 1)Ubiquitination-41.2521906983
89UbiquitinationSDQLVLGKKDMGWPF
CCEEEECCCCCCCCC		41.2522817900
90UbiquitinationDQLVLGKKDMGWPFQ
CEEEECCCCCCCCCC		51.6622817900
97 (in isoform 2)Ubiquitination-34.1721906983
97UbiquitinationKDMGWPFQADGQEGP
CCCCCCCCCCCCCCC		34.1722817900
98UbiquitinationDMGWPFQADGQEGPL
CCCCCCCCCCCCCCC		24.2322817900
140PhosphorylationHEPAFDSSSEEEEEE
CCCCCCCCCHHHHHC		43.5423879269
141PhosphorylationEPAFDSSSEEEEEEV
CCCCCCCCHHHHHCC		53.6423879269
266UbiquitinationGRRCGCVLVESECVC
CCCCCEEEEECCCEE		4.04-
266UbiquitinationGRRCGCVLVESECVC
CCCCCEEEEECCCEE		4.0422505724
269UbiquitinationCGCVLVESECVCKRE
CCEEEEECCCEECHH		28.90-
274UbiquitinationVESECVCKREKLLGD
EECCCEECHHHHHHC		43.1022505724
277UbiquitinationECVCKREKLLGDVLC
CCEECHHHHHHCEEH		53.71-
282UbiquitinationREKLLGDVLCLVHHH
HHHHHHCEEHHHCCC		3.7422505724
290UbiquitinationLCLVHHHRDPSAVLG
EHHHCCCCCHHHHHH		53.85-
298UbiquitinationDPSAVLGKCSSSIKA
CHHHHHHHCCHHHHH		27.12-
451PhosphorylationLTSYHFKTALMHLLL
CCHHHHHHHHHHHHH		24.8722210691
509PhosphorylationLTIPIPKTFRNAEPV
EECCCCCCCCCCCCC		23.60-
519UbiquitinationNAEPVNLFQHLVLNP
CCCCCCHHHHHHCCH		3.47-
527UbiquitinationQHLVLNPKAHSQAVE
HHHHCCHHHHHHHHH		58.62-
536UbiquitinationHSQAVEEFQNLLTQV
HHHHHHHHHHHHHHH		3.5529967540
536UbiquitinationHSQAVEEFQNLLTQV
HHHHHHHHHHHHHHH		3.55-
544UbiquitinationQNLLTQVKTLPHAPL
HHHHHHHHCCCCCCC		34.2329967540
552UbiquitinationTLPHAPLAAAP----
CCCCCCCCCCC----		10.6629967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IPIL1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IPIL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IPIL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SGTA_HUMANSGTAphysical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IPIL1_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-77 AND SER-81, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory