FRMD5_HUMAN - dbPTM
FRMD5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRMD5_HUMAN
UniProt AC Q7Z6J6
Protein Name FERM domain-containing protein 5
Gene Name FRMD5
Organism Homo sapiens (Human).
Sequence Length 570
Subcellular Localization Membrane
Single-pass membrane protein . Cell junction, adherens junction .
Protein Description May be involved in regulation of cell migration. [PubMed: 22846708]
Protein Sequence MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIADEAYSPADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELRALCQGHSGPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSLLIDT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MLSRLMSGSS
-----CCCHHCCCCC		23.2828509920
7Phosphorylation-MLSRLMSGSSRSLE
-CCCHHCCCCCCCCC		39.8630266825
9PhosphorylationLSRLMSGSSRSLERE
CCHHCCCCCCCCCCE		18.4430266825
10PhosphorylationSRLMSGSSRSLEREY
CHHCCCCCCCCCCEE		29.4330266825
12PhosphorylationLMSGSSRSLEREYSC
HCCCCCCCCCCEEEE		36.2122777824
41PhosphorylationQRDAKGQYLFDLLCH
EECCCCHHHHHHHHH		20.29-
97PhosphorylationMCFRVKFYPADPAAL
EEEEEEECCCCHHHH		7.56-
160UbiquitinationHPEGYSSKFQFFPKH
CCCCCCCCCCCCHHH		36.93-
180UbiquitinationRKIAEIHKTELSGQT
HHHHHHHHHHHCCCC		49.72-
187PhosphorylationKTELSGQTPATSELN
HHHHCCCCCCCHHHH		20.58-
190PhosphorylationLSGQTPATSELNFLR
HCCCCCCCHHHHHHH		24.76-
191PhosphorylationSGQTPATSELNFLRK
CCCCCCCHHHHHHHH		42.04-
198UbiquitinationSELNFLRKAQTLETY
HHHHHHHHCCCHHHC		47.17-
255PhosphorylationKLKFEGKTFYLYVSQ
EEEECCEEEEEEEEC		28.5029083192
257PhosphorylationKFEGKTFYLYVSQKE
EECCEEEEEEEECCC		11.4529083192
259PhosphorylationEGKTFYLYVSQKEEK
CCEEEEEEEECCCCC		6.1529083192
261PhosphorylationKTFYLYVSQKEEKKI
EEEEEEEECCCCCEE		23.2129083192
304PhosphorylationEKSSQVRTVSSSNLF
CCCCCEEEEECCCCE		26.3623403867
306PhosphorylationSSQVRTVSSSNLFFK
CCCEEEEECCCCEEC		27.6923403867
307PhosphorylationSQVRTVSSSNLFFKG
CCEEEEECCCCEECC		20.9323403867
308PhosphorylationQVRTVSSSNLFFKGS
CEEEEECCCCEECCC		30.0023403867
313MethylationSSSNLFFKGSRFRYS
ECCCCEECCCCEECC		48.95-
319PhosphorylationFKGSRFRYSGRVAKE
ECCCCEECCHHHHHH		16.8626434776
320PhosphorylationKGSRFRYSGRVAKEV
CCCCEECCHHHHHHH		18.8328355574
349PhosphorylationHRAGMVPSRSCPSIT
HHCCCCCCCCCCCCC		25.9723403867
351PhosphorylationAGMVPSRSCPSITHG
CCCCCCCCCCCCCCC		34.4230266825
354PhosphorylationVPSRSCPSITHGPRL
CCCCCCCCCCCCCCC		44.4330266825
356PhosphorylationSRSCPSITHGPRLSS
CCCCCCCCCCCCCCC		25.7223312004
362PhosphorylationITHGPRLSSVPRTRR
CCCCCCCCCCCCCCC		30.4823403867
363PhosphorylationTHGPRLSSVPRTRRR
CCCCCCCCCCCCCCH		40.5124719451
375PhosphorylationRRRAVHISIMEGLES
CCHHHHHHHHHHHHH		10.8729255136
389PhosphorylationSLRDSAHSTPVRSTS
HHHHHCCCCCCCCCC		33.8423312004
390PhosphorylationLRDSAHSTPVRSTSH
HHHHCCCCCCCCCCC		18.8823312004
394PhosphorylationAHSTPVRSTSHGDTF
CCCCCCCCCCCCCCC		34.2023403867
395PhosphorylationHSTPVRSTSHGDTFL
CCCCCCCCCCCCCCC		17.7423403867
396PhosphorylationSTPVRSTSHGDTFLP
CCCCCCCCCCCCCCC		27.0723911959
400PhosphorylationRSTSHGDTFLPHVRS
CCCCCCCCCCCCCCC		31.5023403867
410PhosphorylationPHVRSSRTDSNERVA
CCCCCCCCCCCCCEE		45.8123898821
453PhosphorylationSRQINGATCSIEEEK
HHHHCCCCCCCHHHH		14.2630624053
455PhosphorylationQINGATCSIEEEKES
HHCCCCCCCHHHHHC		28.7830624053
462PhosphorylationSIEEEKESEASTPTA
CCHHHHHCCCCCCCH		49.9122199227
465PhosphorylationEEKESEASTPTATEV
HHHHCCCCCCCHHHH		30.7629255136
466PhosphorylationEKESEASTPTATEVE
HHHCCCCCCCHHHHH		31.5429255136
468PhosphorylationESEASTPTATEVEAL
HCCCCCCCHHHHHHH		46.4229255136
470PhosphorylationEASTPTATEVEALGG
CCCCCCHHHHHHHHH		42.9427732954
500PhosphorylationQVNKFVLSVLRLLLV
HHHHHHHHHHHHHHH		17.5024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRMD5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRMD5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRMD5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
1433B_HUMANYWHABphysical
24366813
1433F_HUMANYWHAHphysical
24366813
1433G_HUMANYWHAGphysical
24366813
1433T_HUMANYWHAQphysical
24366813
BAG5_HUMANBAG5physical
24366813
CYBP_HUMANCACYBPphysical
24366813
DNJA1_HUMANDNAJA1physical
24366813
F234B_HUMANKIAA1467physical
24366813
KAP0_HUMANPRKAR1Aphysical
24366813
NRCAM_HUMANNRCAMphysical
24366813
RCN2_HUMANRCN2physical
24366813
RS17_HUMANRPS17physical
24366813
TBA1C_HUMANTUBA1Cphysical
24366813
TEBP_HUMANPTGES3physical
24366813
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRMD5_HUMAN

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Related Literatures of Post-Translational Modification

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