S27A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S27A3_HUMAN
• UniProt AC: Q5K4L6
• Protein Name: Long-chain fatty acid transport protein 3
• Gene Name: SLC27A3
• Organism: Homo sapiens (Human).
• Sequence Length: 730
• Subcellular Localization: Mitochondrion membrane; Multi-pass membrane protein.
• Protein Description: Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity)..
• Protein Sequence: MGVCQRTRAPWKEKSQLERAALGFRKGGSGMFASGWNQTVPIEEAGSMAALLLLPLLLLLPLLLLKLHLWPQLRWLPADLAFAVRALCCKRALRARALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSRRFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAGPGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Methylation	KEKSQLERAALGFRK HHHHHHHHHHHCCCC	33.48	115386913
135	Phosphorylation	HTFLIHGSRRFSYSE CEEEECCCCCCCCCH	13.20	28348404
139	Phosphorylation	IHGSRRFSYSEAERE ECCCCCCCCCHHHHH	26.41	25849741
140	Phosphorylation	HGSRRFSYSEAERES CCCCCCCCCHHHHHH	14.07	22617229
141	Phosphorylation	GSRRFSYSEAERESN CCCCCCCCHHHHHHH	29.18	23403867
169	Phosphorylation	WGPDGGDSGEGSAGE CCCCCCCCCCCCCCC	41.86	26471730
173	Phosphorylation	GGDSGEGSAGEGERA CCCCCCCCCCCCCCC	28.88	26471730
191	Phosphorylation	AGDAAAGSGAEFAGG CCCCCCCCCCCCCCC	30.06	25849741
399	Ubiquitination	IGATVVLKSKFSAGQ CCCEEEEECCCCCCH	39.73	-
436	Ubiquitination	LVNQPPSKAERGHKV HHCCCCCHHHCCCEE	61.10	2190698
436 (in isoform 2)	Ubiquitination	-	61.10	21906983
495	Phosphorylation	RGAVGRASWLYKHIF CCCCCCHHHHHHHHC	19.09	24719451
517 (in isoform 1)	Ubiquitination	-	7.30	21906983
682	Ubiquitination	LATTETFKQQKVRMA HHCCHHHHHHHHHHC	60.27	-
717	Phosphorylation	GAYLPLTTARYSALL CCCCCCHHHHHHHHH	19.47	24719451
720	Phosphorylation	LPLTTARYSALLAGN CCCHHHHHHHHHHCC	8.88	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S27A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S27A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S27A3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIMD1_HUMAN	LIMD1	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
BAG3_HUMAN	BAG3	physical	28514442
CHIP_HUMAN	STUB1	physical	28514442
ATP8_HUMAN	ATP8	physical	28514442
RCCD1_HUMAN	RCCD1	physical	28514442
HSP74_HUMAN	HSPA4	physical	28514442
ATPD_HUMAN	ATP5D	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.