ATPD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPD_HUMAN
• UniProt AC: P30049
• Protein Name: ATP synthase subunit delta, mitochondrial {ECO:0000305}
• Gene Name: ATP5F1D {ECO:0000312|HGNC:HGNC:837}
• Organism: Homo sapiens (Human).
• Sequence Length: 168
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits..
• Protein Sequence: MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFASPTQVFFNGANVRQVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSIAVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQAELVGTADEATRAEIQIRIEANEALVKALE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	ASGPNQMSFTFASPT HCCCCEEEEEECCCC	16.03	-
44	Phosphorylation	QMSFTFASPTQVFFN EEEEEECCCCEEEEC	25.04	-
131	Ubiquitination	MLDLGAAKANLEKAQ HHHHHHHHHHHHHHH	36.95	23503661
136	Acetylation	AAKANLEKAQAELVG HHHHHHHHHHHHHHC	49.30	23954790
136	Succinylation	AAKANLEKAQAELVG HHHHHHHHHHHHHHC	49.30	-
136	Ubiquitination	AAKANLEKAQAELVG HHHHHHHHHHHHHHC	49.30	23503661
136	2-Hydroxyisobutyrylation	AAKANLEKAQAELVG HHHHHHHHHHHHHHC	49.30	-
136	Malonylation	AAKANLEKAQAELVG HHHHHHHHHHHHHHC	49.30	26320211
136	Succinylation	AAKANLEKAQAELVG HHHHHHHHHHHHHHC	49.30	27452117
144	Phosphorylation	AQAELVGTADEATRA HHHHHHCCCCHHHHH	24.37	-
165	Acetylation	EANEALVKALE---- HHHHHHHHHHC----	48.37	25038526
165	Succinylation	EANEALVKALE---- HHHHHHHHHHC----	48.37	-
165	Ubiquitination	EANEALVKALE---- HHHHHHHHHHC----	48.37	24816145
165	Succinylation	EANEALVKALE---- HHHHHHHHHHC----	48.37	27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPA_HUMAN	ATP5A1	physical	26344197
ATPG_HUMAN	ATP5C1	physical	26344197
ATP5I_HUMAN	ATP5I	physical	26344197
ATP5J_HUMAN	ATP5J	physical	26344197
ATPK_HUMAN	ATP5J2	physical	26344197
VA0D1_HUMAN	ATP6V0D1	physical	26344197
COX41_HUMAN	COX4I1	physical	26344197
COX5A_HUMAN	COX5A	physical	26344197
OST48_HUMAN	DDOST	physical	26344197
RT4I1_HUMAN	RTN4IP1	physical	28514442
ATP5E_HUMAN	ATP5E	physical	28514442
F172A_HUMAN	FAM172A	physical	28514442
AUHM_HUMAN	AUH	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
MTG2_HUMAN	MTG2	physical	28514442
ATP8_HUMAN	ATP8	physical	28514442
ATPA_HUMAN	ATP5A1	physical	28514442
AT5F1_HUMAN	ATP5F1	physical	28514442
CPT2_HUMAN	CPT2	physical	28514442
ATP5H_HUMAN	ATP5H	physical	28514442
TOP3A_HUMAN	TOP3A	physical	28514442
TRUA_HUMAN	PUS1	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
ATPO_HUMAN	ATP5O	physical	28514442
DHRS4_HUMAN	DHRS4	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
NPS3A_HUMAN	NIPSNAP3A	physical	28514442
ATP5L_HUMAN	ATP5L	physical	28514442
ATPG_HUMAN	ATP5C1	physical	28514442
PNPT1_HUMAN	PNPT1	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
SYLM_HUMAN	LARS2	physical	28514442
COPB2_HUMAN	COPB2	physical	28514442
SIR3_HUMAN	SIRT3	physical	28514442
ATP5I_HUMAN	ATP5I	physical	28514442
EFTS_HUMAN	TSFM	physical	28514442
CQ080_HUMAN	C17orf80	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.