ZDH13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDH13_HUMAN
• UniProt AC: Q8IUH4
• Protein Name: Palmitoyltransferase ZDHHC13 {ECO:0000305}
• Gene Name: ZDHHC13 {ECO:0000312|HGNC:HGNC:18413}
• Organism: Homo sapiens (Human).
• Sequence Length: 622
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles.
• Protein Description: Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport..
• Protein Sequence: MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMVFHPAREKVLRSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGPGLGS -------CCCCCCCH	14.00	22814378
8	Phosphorylation	MEGPGLGSQCRNHSH CCCCCCCHHCCCCCC	31.02	28857561
25	Phosphorylation	HPPGFGRYGICAHEN CCCCCCCCCCCHHCC	15.95	-
33	Ubiquitination	GICAHENKELANARE CCCHHCCHHHHHHHH	51.63	33845483
38 (in isoform 2)	Ubiquitination	-	12.70	-
53	Ubiquitination	EDSSNCDIVKATQYG CCCCCCCHHHHHHHC	3.59	22505724
55	Ubiquitination	SSNCDIVKATQYGIF CCCCCHHHHHHHCHH	46.15	32015554
59	Phosphorylation	DIVKATQYGIFERCK CHHHHHHHCHHHHHH	14.08	25884760
62	Ubiquitination	KATQYGIFERCKELV HHHHHCHHHHHHHHH	4.15	29967540
66	Ubiquitination	YGIFERCKELVEAGY HCHHHHHHHHHHCCC	61.37	29967540
73 (in isoform 2)	Ubiquitination	-	20.50	21906983
73	Phosphorylation	KELVEAGYDVRQPDK HHHHHCCCCCCCCCC	20.50	25884760
75	Ubiquitination	LVEAGYDVRQPDKEN HHHCCCCCCCCCCCC	4.63	22505724
76	Methylation	VEAGYDVRQPDKENV HHCCCCCCCCCCCCC	39.14	-
80 (in isoform 1)	Ubiquitination	-	58.85	21890473
80	Ubiquitination	YDVRQPDKENVSLLH CCCCCCCCCCCCHHH	58.85	33845483
84	Ubiquitination	QPDKENVSLLHWAAI CCCCCCCCHHHHHHH	36.47	32015554
100	Ubiquitination	NRLDLVKFYISKGAV CCHHHHHHHHCCCCC	5.23	21890473
105	Ubiquitination	VKFYISKGAVVDQLG HHHHHCCCCCCHHCC	19.47	29967540
119 (in isoform 3)	Ubiquitination	-	23.27	21906983
119	Ubiquitination	GGDLNSTPLHWAIRQ CCCCCCCCHHHHHHC	23.27	32015554
131	Ubiquitination	IRQGHLPMVILLLQH HHCCCCCCEEHHHHC	3.54	29967540
140	Ubiquitination	ILLLQHGADPTLIDG EHHHHCCCCCEEECC	19.93	33845483
192	Ubiquitination	PLMLSAHKVIGPEPT CEEEEEEEEECCCCC	34.95	29967540
214	Ubiquitination	PSLNVVDKIHQNTPL CCCCHHCCCCCCCCC	30.40	32015554
234	Ubiquitination	AGNVNAVDKLLEAGS CCCCCHHHHHHHCCC	33.21	23503661
235	Ubiquitination	GNVNAVDKLLEAGSS CCCCHHHHHHHCCCC	48.66	29967540
249 (in isoform 1)	Ubiquitination	-	59.59	21890473
249	Ubiquitination	SLDIQNVKGETPLDM CCCCCCCCCCCHHHH	59.59	32015554
261	Ubiquitination	LDMALQNKNQLIIHM HHHHHHCCCHHHHHH	32.86	29967540
269	Ubiquitination	NQLIIHMLKTEAKMR CHHHHHHHHHHHHHH	3.72	23503661
270	Ubiquitination	QLIIHMLKTEAKMRA HHHHHHHHHHHHHHH	36.42	33845483
274	Ubiquitination	HMLKTEAKMRANQKF HHHHHHHHHHHHHHH	23.76	-
308	Phosphorylation	ITMWAIGYILDFNSD HHHHHHHHHHCCCCC	7.69	22210691
314	Phosphorylation	GYILDFNSDSWLLKG HHHHCCCCCCHHHHH	32.77	22210691
316	Phosphorylation	ILDFNSDSWLLKGCL HHCCCCCCHHHHHHH	21.31	22210691
421	Phosphorylation	ITLAETGSLDFRTFC EEEEECCCCCHHHHH	31.99	24719451
436	Ubiquitination	TSCLIRKPLRSLHCH HHHHHCCCHHHCCCC	24.13	29967540
557	Phosphorylation	LTSHERISLQKQSKH CCCHHHHHHHHHCHH	30.85	24719451
566	Ubiquitination	QKQSKHMKQTLSLRK HHHCHHHHHHHHCCC	39.59	29967540
570	Phosphorylation	KHMKQTLSLRKTPYN HHHHHHHHCCCCCCC	29.52	24719451
607	Phosphorylation	VVDWTSQYTMVFHPA EEECCCCCEEEECHH	9.14	24719451
608	Phosphorylation	VDWTSQYTMVFHPAR EECCCCCEEEECHHH	10.14	24719451
621	Phosphorylation	AREKVLRSV------ HHHHHHHCC------	28.19	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
8	S	Phosphorylation	Kinase	ATR	Q13535	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDH13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDH13_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDH13_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.