| UniProt ID | ABCD4_HUMAN | |
|---|---|---|
| UniProt AC | O14678 | |
| Protein Name | ATP-binding cassette sub-family D member 4 | |
| Gene Name | ABCD4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 606 | |
| Subcellular Localization |
Peroxisome membrane Multi-pass membrane protein. |
|
| Protein Description | May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.. | |
| Protein Sequence | MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWELMRIKVE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 81 | Phosphorylation | KDLEGFKTLTFLAVM CCCCHHHHHHHHHHH | 28.86 | 22210691 | |
| 94 | Phosphorylation | VMLIVLNSTLKSFDQ HHHHHHHHHCCCCCH | 30.84 | 22210691 | |
| 116 | Phosphorylation | VSWRKDLTEHLHRLY EEECHHHHHHHHHHH | 31.34 | 113299693 | |
| 217 | Ubiquitination | MKLVHQEKLEGDFRF HHHHCHHHHCCCCEE | 45.31 | - | |
| 225 | Ubiquitination | LEGDFRFKHMQIRVN HCCCCEEEEEEEEEC | 33.63 | - | |
| 355 | Phosphorylation | RETLLDMSLKSQDCE HHHHHHHHCHHCCCE | 32.10 | 24719451 | |
| 393 | Phosphorylation | AFLLERVSISAPSSD HEEEEEEECCCCCCC | 19.63 | 30631047 | |
| 395 | Phosphorylation | LLERVSISAPSSDKP EEEEEECCCCCCCCC | 26.99 | 30631047 | |
| 398 | Phosphorylation | RVSISAPSSDKPLIK EEECCCCCCCCCCEE | 51.38 | 46156841 | |
| 399 | Phosphorylation | VSISAPSSDKPLIKD EECCCCCCCCCCEEE | 48.90 | 46156847 | |
| 401 | Ubiquitination | ISAPSSDKPLIKDLS CCCCCCCCCCEEEEE | 43.61 | - | |
| 427 | Ubiquitination | TGNTGTGKTSLLRVL ECCCCCCHHHHHHHH | 34.48 | - | |
| 429 | Phosphorylation | NTGTGKTSLLRVLGG CCCCCHHHHHHHHHC | 28.97 | 24719451 | |
| 439 | Phosphorylation | RVLGGLWTSTRGSVQ HHHHCCHHCCCCCEE | 25.84 | 24702127 | |
| 440 | Phosphorylation | VLGGLWTSTRGSVQM HHHCCHHCCCCCEEE | 12.43 | 24702127 | |
| 441 | Phosphorylation | LGGLWTSTRGSVQML HHCCHHCCCCCEEEC | 31.51 | 24702127 | |
| 479 | Ubiquitination | EQVIYPLKEVYPDSG CEEEEEHHHHCCCCC | 40.40 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ABCD4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ABCD4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ABCD4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| XRCC6_HUMAN | XRCC6 | physical | 16169070 | |
| PEA15_HUMAN | PEA15 | physical | 16169070 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614857 | Methylmalonic aciduria and homocystinuria type cblJ (MAHCJ) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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