EDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDA_HUMAN
• UniProt AC: Q92838
• Protein Name: Ectodysplasin-A
• Gene Name: EDA
• Organism: Homo sapiens (Human).
• Sequence Length: 391
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein .; Ectodysplasin-A, secreted form: Secreted .
• Protein Description: Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. [PubMed: 8696334]
• Protein Sequence: MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCCYLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAALHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRLGEAPAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	CCYLELRSELRRERG HHHHHHHHHHHHHHC	54.32	22210691
313	N-linked_Glycosylation	QVEVYYINFTDFASY EEEEEEEECCCCCCE	20.04	UniProtKB CARBOHYD
372	N-linked_Glycosylation	VHADISINMSKHTTF EECCEEEECCCCCEE	23.14	UniProtKB CARBOHYD
374	Phosphorylation	ADISINMSKHTTFFG CCEEEECCCCCEEEE	19.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EDAR_HUMAN	EDAR	physical	11309369
EMP3_HUMAN	EMP3	physical	25416956
MAL_HUMAN	MAL	physical	25416956
PPLA_HUMAN	PLN	physical	25416956
DOLK_HUMAN	DOLK	physical	25416956
LERL1_HUMAN	LEPROTL1	physical	25416956
SC22A_HUMAN	SEC22A	physical	25416956
GIMA5_HUMAN	GIMAP5	physical	25416956
NPAL3_HUMAN	NIPAL3	physical	25416956
OSTC_HUMAN	OSTC	physical	25416956
AP3M1_HUMAN	AP3M1	physical	26186194
AP3M2_HUMAN	AP3M2	physical	26186194
VMA21_HUMAN	VMA21	physical	26186194
UBR4_HUMAN	UBR4	physical	26186194
IPO7_HUMAN	IPO7	physical	26186194
SRRM2_HUMAN	SRRM2	physical	26186194
CRTAP_HUMAN	CRTAP	physical	26186194
UBF1_HUMAN	UBTF	physical	26186194
AP3B2_HUMAN	AP3B2	physical	26186194
AP3B1_HUMAN	AP3B1	physical	26186194
P3H2_HUMAN	P3H2	physical	26186194
P3H1_HUMAN	P3H1	physical	26186194
CWC27_HUMAN	CWC27	physical	26186194
CWC22_HUMAN	CWC22	physical	26186194
PININ_HUMAN	PNN	physical	26186194
NAF1_HUMAN	NAF1	physical	26186194
RNPS1_HUMAN	RNPS1	physical	26186194
LNP_HUMAN	KIAA1715	physical	26186194
AF9_HUMAN	MLLT3	physical	26186194
IF4A3_HUMAN	EIF4A3	physical	26186194
ALG5_HUMAN	ALG5	physical	26186194
OSBL8_HUMAN	OSBPL8	physical	26186194
TMUB1_HUMAN	TMUB1	physical	26186194
TNC18_HUMAN	TNRC18	physical	26186194
AFF4_HUMAN	AFF4	physical	26186194
SAHH2_HUMAN	AHCYL1	physical	26186194
CXXC1_HUMAN	CXXC1	physical	26186194
NOC2L_HUMAN	NOC2L	physical	26186194
SET1A_HUMAN	SETD1A	physical	26186194
KBTB7_HUMAN	KBTBD7	physical	26186194
CIZ1_HUMAN	CIZ1	physical	26186194
GPM6A_HUMAN	GPM6A	physical	26186194
SIN3A_HUMAN	SIN3A	physical	26186194
KCMF1_HUMAN	KCMF1	physical	26186194
JPH1_HUMAN	JPH1	physical	26186194
UBF1_HUMAN	UBTF	physical	28514442
CWC22_HUMAN	CWC22	physical	28514442
P3H2_HUMAN	P3H2	physical	28514442
AP3B2_HUMAN	AP3B2	physical	28514442
AP3B1_HUMAN	AP3B1	physical	28514442
AP3M2_HUMAN	AP3M2	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
NAF1_HUMAN	NAF1	physical	28514442
CXXC1_HUMAN	CXXC1	physical	28514442
CRTAP_HUMAN	CRTAP	physical	28514442
VMA21_HUMAN	VMA21	physical	28514442
ALG5_HUMAN	ALG5	physical	28514442
PININ_HUMAN	PNN	physical	28514442
AP3M1_HUMAN	AP3M1	physical	28514442
TNC18_HUMAN	TNRC18	physical	28514442
SRRM2_HUMAN	SRRM2	physical	28514442
SAHH2_HUMAN	AHCYL1	physical	28514442
GPM6A_HUMAN	GPM6A	physical	28514442
CWC27_HUMAN	CWC27	physical	28514442
P3H1_HUMAN	P3H1	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
OSBL8_HUMAN	OSBPL8	physical	28514442
SET1A_HUMAN	SETD1A	physical	28514442
CIZ1_HUMAN	CIZ1	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00625: Tooth agenesis; Hypodontia
• H00651: Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidroti
• OMIM Disease
• 305100: Ectodermal dysplasia 1, hypohidrotic, X-linked (XHED)
• 313500: Tooth agenesis selective X-linked 1 (STHAGX1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.