EDAR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDAR_HUMAN
• UniProt AC: Q9UNE0
• Protein Name: Tumor necrosis factor receptor superfamily member EDAR
• Gene Name: EDAR
• Organism: Homo sapiens (Human).
• Sequence Length: 448
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death..
• Protein Sequence: MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	N-linked_Glycosylation	CGENEYYNQTTGLCQ CCCCCCCCCCCCCCC	31.64	UniProtKB CARBOHYD
153	Phosphorylation	KECVGATSGASANFP HHCCCCCCCCCCCCC	31.65	-
234	Phosphorylation	KSVEAQVSKDEEKKE CCEEEECCCCHHHHC	23.47	28270605
266	Phosphorylation	TATPAKPTKSENDAS CCCCCCCCCCCCCCC	46.63	29116813
268	Phosphorylation	TPAKPTKSENDASSE CCCCCCCCCCCCCHH	44.07	29116813
273	Phosphorylation	TKSENDASSENEQLL CCCCCCCCHHHHHHH	40.84	29116813
274	Phosphorylation	KSENDASSENEQLLS CCCCCCCHHHHHHHH	46.27	28355574
281	Phosphorylation	SENEQLLSRSVDSDE HHHHHHHHCCCCCCC	30.97	27794612
283	Phosphorylation	NEQLLSRSVDSDEEP HHHHHHCCCCCCCCC	27.22	28060719
286	Phosphorylation	LLSRSVDSDEEPAPD HHHCCCCCCCCCCCC	44.78	29432917
297	Phosphorylation	PAPDKQGSPELCLLS CCCCCCCCHHHHHHH	16.83	29116813
304	Phosphorylation	SPELCLLSLVHLARE CHHHHHHHHHHHHHH	18.52	23312004
324	Phosphorylation	NKSAGIQSRRKKILD CCCHHHHHHHHHHHH	31.94	14729942
357	Phosphorylation	FDCLEKTSRMLSSTY HHHHHHHHHHHHHCC	27.10	-
361	Phosphorylation	EKTSRMLSSTYNSEK HHHHHHHHHCCCHHH	15.99	29978859
362	Phosphorylation	KTSRMLSSTYNSEKA HHHHHHHHCCCHHHH	30.83	29978859
363	Phosphorylation	TSRMLSSTYNSEKAV HHHHHHHCCCHHHHH	24.28	29978859
364	Phosphorylation	SRMLSSTYNSEKAVV HHHHHHCCCHHHHHH	20.74	29255136
366	Phosphorylation	MLSSTYNSEKAVVKT HHHHCCCHHHHHHHH	30.02	29255136
392	Phosphorylation	RDEIGGMTDGMQLFD HHHHCCCCCHHHHHH	32.45	28509920
402	Phosphorylation	MQLFDRISTAGYSIP HHHHHHHHCCCCCHH	17.07	30624053
403	Phosphorylation	QLFDRISTAGYSIPE HHHHHHHCCCCCHHH	23.02	30624053
406	Phosphorylation	DRISTAGYSIPELLT HHHHCCCCCHHHHHH	10.85	30624053
407	Phosphorylation	RISTAGYSIPELLTK HHHCCCCCHHHHHHH	30.65	30624053

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MIB1	Q86YT6	PMID:20176925
-	K	Ubiquitination	E3 ubiquitin ligase	NEURL1B	A8MQ27	PMID:20176925

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDAR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDAR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EDAD_HUMAN	EDARADD	physical	11882293
TRADD_HUMAN	TRADD	physical	11035039
FADD_HUMAN	FADD	physical	11035039
TRAF1_MOUSE	Traf1	physical	11035039
TRAF2_MOUSE	Traf2	physical	11035039
EDA_MOUSE	Eda	physical	11035039

Drug and Disease Associations

• Kegg Disease
• H00651: Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidroti
• OMIM Disease
• 129490: Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant (ECTD10A)
• 224900: Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD10B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.