| UniProt ID | NPAL3_HUMAN | |
|---|---|---|
| UniProt AC | Q6P499 | |
| Protein Name | NIPA-like protein 3 | |
| Gene Name | NIPAL3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 406 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | ||
| Protein Sequence | MDGSHSAALKLQQLPPTSSSSAVSEASFSYKENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIFIKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEIILFCLLLYFYKEKNANNIVVILLLVALLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPGMQNMHDKGMTVQPELKASFSYGALENNDNISEIYAPATLPVMQEEHGSRSASGVPYRVLEHTKKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | O-linked_Glycosylation | QQLPPTSSSSAVSEA HHCCCCCCCCCCCCC | 30.69 | OGP | |
| 21 | O-linked_Glycosylation | LPPTSSSSAVSEASF CCCCCCCCCCCCCCC | 34.34 | OGP | |
| 24 | Phosphorylation | TSSSSAVSEASFSYK CCCCCCCCCCCCCCH | 27.45 | 29759185 | |
| 30 | Phosphorylation | VSEASFSYKENLIGA CCCCCCCCHHHHHHH | 21.95 | 22210691 | |
| 70 | Phosphorylation | GSKDPRAYFKTKTWW CCCCHHHHHHHHHHH | 13.59 | 23532336 | |
| 166 | N-linked_Glycosylation | HEKMTGENVTRHLVS CCCCCCCHHHHHHHH | 41.63 | UniProtKB CARBOHYD | |
| 333 | Phosphorylation | KPIPFEPYISMDAMP CCCCCCCCCCCCCCC | 9.83 | 28796482 | |
| 335 | Phosphorylation | IPFEPYISMDAMPGM CCCCCCCCCCCCCCC | 12.55 | 28796482 | |
| 359 | Phosphorylation | VQPELKASFSYGALE CCHHHHHHHEECCCC | 17.09 | 28464451 | |
| 361 | Phosphorylation | PELKASFSYGALENN HHHHHHHEECCCCCC | 21.84 | 28450419 | |
| 362 | Phosphorylation | ELKASFSYGALENND HHHHHHEECCCCCCC | 12.38 | 28450419 | |
| 372 | Phosphorylation | LENNDNISEIYAPAT CCCCCCCCEEECCCC | 24.97 | 21082442 | |
| 375 | Phosphorylation | NDNISEIYAPATLPV CCCCCEEECCCCCHH | 11.50 | 27251275 | |
| 379 | Phosphorylation | SEIYAPATLPVMQEE CEEECCCCCHHCCHH | 30.45 | 28122231 | |
| 391 | Phosphorylation | QEEHGSRSASGVPYR CHHHCCCCCCCCCCH | 28.60 | 28348404 | |
| 397 | Phosphorylation | RSASGVPYRVLEHTK CCCCCCCCHHHCCCC | 15.79 | 24719451 | |
| 403 | Phosphorylation | PYRVLEHTKKE---- CCHHHCCCCCC---- | 34.14 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NPAL3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NPAL3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NPAL3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| VPS45_HUMAN | VPS45 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, AND MASSSPECTROMETRY. | |
