| UniProt ID | DOLK_HUMAN | |
|---|---|---|
| UniProt AC | Q9UPQ8 | |
| Protein Name | Dolichol kinase | |
| Gene Name | DOLK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 538 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.. | |
| Protein Sequence | MTRECPSPAPGPGAPLSGSVLAEAAVVFAVVLSIHATVWDRYSWCAVALAVQAFYVQYKWDRLLQQGSAVFQFRMSANSGLLPASMVMPLLGLVMKERCQTAGNPFFERFGIVVAATGMAVALFSSVLALGITRPVPTNTCVILGLAGGVIIYIMKHSLSVGEVIEVLEVLLIFVYLNMILLYLLPRCFTPGEALLVLGGISFVLNQLIKRSLTLVESQGDPVDFFLLVVVVGMVLMGIFFSTLFVFMDSGTWASSIFFHLMTCVLSLGVVLPWLHRLIRRNPLLWLLQFLFQTDTRIYLLAYWSLLATLACLVVLYQNAKRSSSESKKHQAPTIARKYFHLIVVATYIPGIIFDRPLLYVAATVCLAVFIFLEYVRYFRIKPLGHTLRSFLSLFLDERDSGPLILTHIYLLLGMSLPIWLIPRPCTQKGSLGGARALVPYAGVLAVGVGDTVASIFGSTMGEIRWPGTKKTFEGTMTSIFAQIISVALILIFDSGVDLNYSYAWILGSISTVSLLEAYTTQIDNLLLPLYLLILLMA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MTRECPSPAPGPGA -CCCCCCCCCCCCCC | 45.40 | 26074081 | |
| 79 | Phosphorylation | QFRMSANSGLLPASM EEECCCCCCCCCHHH | 30.45 | 29759185 | |
| 85 | Phosphorylation | NSGLLPASMVMPLLG CCCCCCHHHHHHHHH | 15.23 | 29759185 | |
| 117 | Phosphorylation | FGIVVAATGMAVALF HCHHHHHHHHHHHHH | 20.11 | 22210691 | |
| 125 | Phosphorylation | GMAVALFSSVLALGI HHHHHHHHHHHHHCC | 22.01 | 22210691 | |
| 299 | Phosphorylation | FQTDTRIYLLAYWSL CCCCHHHHHHHHHHH | 7.74 | - | |
| 360 | Phosphorylation | IFDRPLLYVAATVCL CCCCHHHHHHHHHHH | 8.84 | - | |
| 375 | Phosphorylation | AVFIFLEYVRYFRIK HHHHHHHHHHHHCCC | 7.74 | - | |
| 452 | Phosphorylation | LAVGVGDTVASIFGS EEEECCHHHHHHHCC | 16.43 | 22210691 | |
| 455 | Phosphorylation | GVGDTVASIFGSTMG ECCHHHHHHHCCCCC | 17.70 | 28348404 | |
| 459 | Phosphorylation | TVASIFGSTMGEIRW HHHHHHCCCCCEEEC | 12.41 | 28348404 | |
| 460 | Phosphorylation | VASIFGSTMGEIRWP HHHHHCCCCCEEECC | 29.58 | 28348404 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DOLK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DOLK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DOLK_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DOLK_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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