P3H2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P3H2_HUMAN
• UniProt AC: Q8IVL5
• Protein Name: Prolyl 3-hydroxylase 2 {ECO:0000312|HGNC:HGNC:19317}
• Gene Name: P3H2 {ECO:0000312|HGNC:HGNC:19317}
• Organism: Homo sapiens (Human).
• Sequence Length: 708
• Subcellular Localization: Endoplasmic reticulum . Sarcoplasmic reticulum . Golgi apparatus .
• Protein Description: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. [PubMed: 18487197 Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1]
• Protein Sequence: MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYASGAAAYYSGDYERAVRDLEAALRSHRRLREIRTRCARHCAARHPLPPPPPGEGPGAELPLFRSLLGRARCYRSCETQRLGGPASRHRVSEDVRSDFQRRVPYNYLQRAYIKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILDQEQQGKHELNINPKDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	PPLWGGPPDSPRREL CCCCCCCCCCCCCCC	58.97	29967540
112	Phosphorylation	AELPLFRSLLGRARC CCCHHHHHHHCCHHH	22.17	27251275
143	Ubiquitination	RVSEDVRSDFQRRVP CCCHHHHHHHHHHCC	42.50	21963094
143	Ubiquitination	RVSEDVRSDFQRRVP CCCHHHHHHHHHHCC	42.50	-
160	Ubiquitination	YLQRAYIKLNQLEKA HHHHHHHHHHHHHHH	28.80	21963094
166	Ubiquitination	IKLNQLEKAVEAAHT HHHHHHHHHHHHHHH	67.34	29967540
191	Phosphorylation	MQQNIENYRATAGVE HHHHHHHHHHHHHHH	6.71	23663014
192	Ubiquitination	QQNIENYRATAGVEA HHHHHHHHHHHHHHH	36.72	22817900
195	Ubiquitination	IENYRATAGVEALQL HHHHHHHHHHHHHHH	21.03	-
195	Ubiquitination	IENYRATAGVEALQL HHHHHHHHHHHHHHH	21.03	21963094
202	Ubiquitination	AGVEALQLVDREAKP HHHHHHHHHCCCCCC	4.50	21963094
202	Ubiquitination	AGVEALQLVDREAKP HHHHHHHHHCCCCCC	4.50	-
208	Ubiquitination	QLVDREAKPHMESYN HHHCCCCCCCHHHCC	30.61	29967540
248	Ubiquitination	FVEDTECRTLCEGPQ HCCCCCCHHCCCCCC	25.22	29967540
253	Ubiquitination	ECRTLCEGPQRFEEY CCHHCCCCCCHHHHH	23.73	29967540
315	Ubiquitination	HYDYLQFAYYRVGEY CCHHHHHHHHHHHHH	6.36	29967540
324	Ubiquitination	YRVGEYVKALECAKA HHHHHHHHHHHHHHH	46.48	21963094
324	Ubiquitination	YRVGEYVKALECAKA HHHHHHHHHHHHHHH	46.48	-
332	Ubiquitination	ALECAKAYLLCHPDD HHHHHHHHHHCCCCC	10.25	-
332	Ubiquitination	ALECAKAYLLCHPDD HHHHHHHHHHCCCCC	10.25	21963094
335	Ubiquitination	CAKAYLLCHPDDEDV HHHHHHHCCCCCCCH	3.95	-
335	Ubiquitination	CAKAYLLCHPDDEDV HHHHHHHCCCCCCCH	3.95	21963094
373	Ubiquitination	EDLTMFVKRHKLESE HHHHHHHHHHHHHHH	37.20	22817900
376	Ubiquitination	TMFVKRHKLESELIK HHHHHHHHHHHHHHH	58.96	21963094
383	Ubiquitination	KLESELIKSAAEGLG HHHHHHHHHHHHHCC	46.82	21963094
414	Ubiquitination	DENRVPSGVNVEGAE CCCCCCCCCCCCCCE	14.67	21963094
414	Ubiquitination	DENRVPSGVNVEGAE CCCCCCCCCCCCCCE	14.67	-
429	Ubiquitination	VHGFSMGKKLSPKID EEEECCCCCCCCCCC	41.73	29967540
434	Ubiquitination	MGKKLSPKIDRDLRE CCCCCCCCCCHHHHC	54.59	29967540
449	N-linked_Glycosylation	GGPLLYENITFVYNS CCCEEEEEEEEEEEH	25.66	UniProtKB CARBOHYD
454	Ubiquitination	YENITFVYNSEQLNG EEEEEEEEEHHHCCC	14.58	29967540
456	Ubiquitination	NITFVYNSEQLNGTQ EEEEEEEHHHCCCCE	14.72	29967540
474	Ubiquitination	LDNVLSEEQCRELHS HHHCCCHHHHHHHHH	52.16	21963094
474	Ubiquitination	LDNVLSEEQCRELHS HHHCCCHHHHHHHHH	52.16	-
478	Ubiquitination	LSEEQCRELHSVASG CCHHHHHHHHHHHCE	59.46	22817900
496	Ubiquitination	VGDGYRGKTSPHTPN ECCCCCCCCCCCCCC	36.51	29967540
505	Ubiquitination	SPHTPNEKFEGATVL CCCCCCCCCCHHHHH	56.19	21963094
513	Ubiquitination	FEGATVLKALKSGYE CCHHHHHHHHHCCCC	47.54	21963094
516	Ubiquitination	ATVLKALKSGYEGRV HHHHHHHHCCCCCCC	46.85	-
516	Ubiquitination	ATVLKALKSGYEGRV HHHHHHHHCCCCCCC	46.85	21963094
524	Ubiquitination	SGYEGRVPLKSARLF CCCCCCCCCCHHEEE	32.48	29967540
532	Phosphorylation	LKSARLFYDISEKAR CCHHEEEEEHHHHHH	19.57	24732914
535	Phosphorylation	ARLFYDISEKARRIV HEEEEEHHHHHHHHH	30.10	24732914
549	N-linked_Glycosylation	VESYFMLNSTLYFSY HHHHHCHHCEEEEEH	22.59	UniProtKB CARBOHYD
595	Ubiquitination	PEANECWKEPPAYTF CCHHHHCCCCCCEEC	72.50	21963094
600	Phosphorylation	CWKEPPAYTFRDYSA HCCCCCCEECCCCEE	16.51	21406692
601	Phosphorylation	WKEPPAYTFRDYSAL CCCCCCEECCCCEEE	17.82	21406692
635	Ubiquitination	KTVTASIKPKCGRMI CEEEEECCCCCCCEE	35.61	29967540
637	Ubiquitination	VTASIKPKCGRMISF EEEECCCCCCCEEEE	44.30	29967540
655	Ubiquitination	GENPHGVKAVTKGKR CCCCCCCEECCCCCC	41.55	21963094
659	Ubiquitination	HGVKAVTKGKRCAVA CCCEECCCCCCEEEE	56.70	22817900
697	Ubiquitination	LDQEQQGKHELNINP ECHHHCCCCCCCCCC	29.57	21963094
705	Ubiquitination	HELNINPKDEL---- CCCCCCCCCCC----	60.39	29967540
705	"N6,N6-dimethyllysine"	HELNINPKDEL---- CCCCCCCCCCC----	60.39	-
705	Methylation	HELNINPKDEL---- CCCCCCCCCCC----	60.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P3H2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P3H2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P3H2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of P3H2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.