UniProt ID | AP3M2_HUMAN | |
---|---|---|
UniProt AC | P53677 | |
Protein Name | AP-3 complex subunit mu-2 | |
Gene Name | AP3M2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 418 | |
Subcellular Localization |
Golgi apparatus. Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.. |
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Protein Description | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.. | |
Protein Sequence | MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSLQAGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
31 | Phosphorylation | VSRSVCDYFFEAQER HHHHHHHHHHHHHHH | 12.68 | - | |
58 | Phosphorylation | TPHHYLLSVYRHKIF CCCHHHHHHHHCCCE | 17.95 | 24719451 | |
60 | Phosphorylation | HHYLLSVYRHKIFFV CHHHHHHHHCCCEEE | 12.01 | - | |
135 | Ubiquitination | NILKELIKPPTILRT HHHHHHCCCCCEEHH | 58.53 | - | |
238 | Methylation | VSFHPCVRFKRWESE CEECCCEECCCCCCC | 37.78 | - | |
281 | Phosphorylation | VYVKHNISFRDSSSL EEEECCEEECCCCCC | 21.39 | 24719451 | |
294 | Phosphorylation | SLGRFEITVGPKQTM CCCCEEEEECCCCCC | 16.53 | - | |
300 | Phosphorylation | ITVGPKQTMGKTIEG EEECCCCCCCCEEEE | 33.73 | - | |
303 | Ubiquitination | GPKQTMGKTIEGVTV CCCCCCCCEEEEEEE | 35.19 | - | |
340 | Phosphorylation | DPVTKMLSWDVGKIN CCCHHHEEEECCCCC | 20.10 | 27499020 | |
353 | Phosphorylation | INPQKLPSLKGTMSL CCHHHCCCCCCCEEE | 53.82 | 24719451 | |
385 | Phosphorylation | KIQQLAISGLKVNRL EEEHHHHCCCEECEE | 32.25 | 28060719 | |
388 | Ubiquitination | QLAISGLKVNRLDMY HHHHCCCEECEEECC | 40.77 | - | |
398 | Ubiquitination | RLDMYGEKYKPFKGI EEECCCCCCCCCCCC | 54.96 | 21890473 | |
398 | Ubiquitination | RLDMYGEKYKPFKGI EEECCCCCCCCCCCC | 54.96 | 21890473 | |
398 | Ubiquitination | RLDMYGEKYKPFKGI EEECCCCCCCCCCCC | 54.96 | 21890473 | |
400 | Ubiquitination | DMYGEKYKPFKGIKY ECCCCCCCCCCCCEE | 55.86 | 21890473 | |
400 | Ubiquitination | DMYGEKYKPFKGIKY ECCCCCCCCCCCCEE | 55.86 | 21890473 | |
400 | Ubiquitination | DMYGEKYKPFKGIKY ECCCCCCCCCCCCEE | 55.86 | 21890473 | |
413 | Ubiquitination | KYMTKAGKFQVRT-- EEEECCCCEEECC-- | 37.17 | - | |
413 | Acetylation | KYMTKAGKFQVRT-- EEEECCCCEEECC-- | 37.17 | 25953088 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AP3M2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AP3M2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AP3M2_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
AP3B1_HUMAN | AP3B1 | physical | 28514442 | |
AP3S2_HUMAN | AP3S2 | physical | 28514442 | |
AP3D1_HUMAN | AP3D1 | physical | 28514442 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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