AP3M2_HUMAN - dbPTM
AP3M2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP3M2_HUMAN
UniProt AC P53677
Protein Name AP-3 complex subunit mu-2
Gene Name AP3M2
Organism Homo sapiens (Human).
Sequence Length 418
Subcellular Localization Golgi apparatus. Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex..
Protein Description Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals..
Protein Sequence MIHSLFLINSSGDIFLEKHWKSVVSRSVCDYFFEAQERATEAENVPPVIPTPHHYLLSVYRHKIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPLATESNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVIEEIDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRLLDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISFRDSSSLGRFEITVGPKQTMGKTIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLSWDVGKINPQKLPSLKGTMSLQAGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEKYKPFKGIKYMTKAGKFQVRT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationVSRSVCDYFFEAQER
HHHHHHHHHHHHHHH
12.68-
58PhosphorylationTPHHYLLSVYRHKIF
CCCHHHHHHHHCCCE
17.9524719451
60PhosphorylationHHYLLSVYRHKIFFV
CHHHHHHHHCCCEEE
12.01-
135UbiquitinationNILKELIKPPTILRT
HHHHHHCCCCCEEHH
58.53-
238MethylationVSFHPCVRFKRWESE
CEECCCEECCCCCCC
37.78-
281PhosphorylationVYVKHNISFRDSSSL
EEEECCEEECCCCCC
21.3924719451
294PhosphorylationSLGRFEITVGPKQTM
CCCCEEEEECCCCCC
16.53-
300PhosphorylationITVGPKQTMGKTIEG
EEECCCCCCCCEEEE
33.73-
303UbiquitinationGPKQTMGKTIEGVTV
CCCCCCCCEEEEEEE
35.19-
340PhosphorylationDPVTKMLSWDVGKIN
CCCHHHEEEECCCCC
20.1027499020
353PhosphorylationINPQKLPSLKGTMSL
CCHHHCCCCCCCEEE
53.8224719451
385PhosphorylationKIQQLAISGLKVNRL
EEEHHHHCCCEECEE
32.2528060719
388UbiquitinationQLAISGLKVNRLDMY
HHHHCCCEECEEECC
40.77-
398UbiquitinationRLDMYGEKYKPFKGI
EEECCCCCCCCCCCC
54.9621890473
398UbiquitinationRLDMYGEKYKPFKGI
EEECCCCCCCCCCCC
54.9621890473
398UbiquitinationRLDMYGEKYKPFKGI
EEECCCCCCCCCCCC
54.9621890473
400UbiquitinationDMYGEKYKPFKGIKY
ECCCCCCCCCCCCEE
55.8621890473
400UbiquitinationDMYGEKYKPFKGIKY
ECCCCCCCCCCCCEE
55.8621890473
400UbiquitinationDMYGEKYKPFKGIKY
ECCCCCCCCCCCCEE
55.8621890473
413UbiquitinationKYMTKAGKFQVRT--
EEEECCCCEEECC--
37.17-
413AcetylationKYMTKAGKFQVRT--
EEEECCCCEEECC--
37.1725953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP3M2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP3M2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP3M2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP3B1_HUMANAP3B1physical
28514442
AP3S2_HUMANAP3S2physical
28514442
AP3D1_HUMANAP3D1physical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP3M2_HUMAN

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Related Literatures of Post-Translational Modification

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