GHDC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GHDC_HUMAN
• UniProt AC: Q8N2G8
• Protein Name: GH3 domain-containing protein
• Gene Name: GHDC
• Organism: Homo sapiens (Human).
• Sequence Length: 530
• Subcellular Localization: Endoplasmic reticulum. Nucleus envelope.
• Protein Sequence: MLLWPLLLLLLLLPTLALLRQQRSQDARLSWLAGLQHRVAWGALVWAATWQRRRLEQSTLHVHQSQQQALRWCLQGAQRPHCSLRRSTDISTFRNHLPLTKASQTQQEDSGEQPLPPTSNQDLGEASLQATLLGLAALNKAYPEVLAQGRTARVTLTSPWPRPLPWPGNTLGQVGTPGTKDPRALLLDALRSPGLRALEAGTAVELLDVFLGLETDGEELAGAIAAGNPGAPLRERAAELREALEQGPRGLALRLWPKLQVVVTLDAGGQAEAVAALGALWCQGLAFFSPAYAASGGVLGLNLQPEQPHGLYLLPPGAPFIELLPVKEGTQEEAASTLLLAEAQQGKEYELVLTDRASLTRCRLGDVVRVVGAYNQCPVVRFICRLDQTLSVRGEDIGEDLFSEALGRAVGQWAGAKLLDHGCVESSILDSSAGSAPHYEVFVALRGLRNLSEENRDKLDHCLQEASPRYKSLRFWGSVGPARVHLVGQGAFRALRAALAACPSSPFPPAMPRVLRHRHLAQCLQERVVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	PHCSLRRSTDISTFR CCCCCCCCCCHHHHH	24.81	30266825
88	Phosphorylation	HCSLRRSTDISTFRN CCCCCCCCCHHHHHH	35.22	30266825
101	Ubiquitination	RNHLPLTKASQTQQE HHCCCCCCCCCCCCC	54.44	-
170	Phosphorylation	PLPWPGNTLGQVGTP CCCCCCCCCCCCCCC	37.87	24719451
347	Ubiquitination	LAEAQQGKEYELVLT HHHHHCCCCEEEEEE	53.43	-
426 (in isoform 2)	Phosphorylation	-	11.41	27732954
427 (in isoform 2)	Phosphorylation	-	17.42	27732954
431	Phosphorylation	VESSILDSSAGSAPH EEHHHHCCCCCCCCH	20.74	-
450	N-linked_Glycosylation	VALRGLRNLSEENRD HHHHHHHCCCHHHHH	53.62	UniProtKB CARBOHYD
467	Phosphorylation	DHCLQEASPRYKSLR HHHHHHCCHHHHHHH	14.79	25159151
470	Phosphorylation	LQEASPRYKSLRFWG HHHCCHHHHHHHEEE	14.33	-
489	Methylation	ARVHLVGQGAFRALR CEEEEEHHHHHHHHH	32.34	26797129

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GHDC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
489	Q	Methylation	Methylated at Gln-489 by N6AMT1.	26797129

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GHDC_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GHDC_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.